6 articles Found
  • Lactobacillus rhamnosus
    Agil Nature

    Lactobacillus rhamnosus

    Overview :  

    Lactobacillus rhamnosus , formerly a subspecies of Lactobacillus casei considered , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Since the bacterium's discovery, it has been the most studied probiotic bacterium in the world, with a large number of studies.  

    Lactobacillus rhamnosus finds Its main use is as a probiotic . Probiotics are living microorganisms that, in certain quantities, provide health benefits. for example by influencing the intestinal microbiome . It is worth mentioning that the current scientific view is that Lactobacillus rhamnosus is only a temporary resident in our intestines and after taking it as a probiotic does not remain permanently in the intestines once you stop taking it.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health: L. rhamnosus In studies, it repaired an already damaged protective barrier in the colon and also stimulated the production of mucin , a building block of this barrier . In mice, this resulted in an improvement in intestinal disorders such as constipation . In addition, it regulates the intestinal flora by promoting the proliferation of beneficial bacteria and inhibiting the growth of harmful bacteria .  

    • Immune system regulation: L. rhamnosus In studies, it has been shown to stimulate the natural immune system and ensure balance. Thanks to its stimulating effect In studies on hamsters and mice, it showed a positive influence on diseases such as inflammatory reactions in rheumatoid arthritis, osteoporosis and chronic inflammation of the colon ( colitis )  

    • Respiratory diseases: Based on studies it is suspected that L . rhamnsosus may play a mild prophylactic role in the prevention and treatment of some respiratory diseases. Since underweight children are associated with a high risk of various infections, L . rhamnosus investigated in this context. Here, too, L . rhamnosus the risk of infection and the resulting respiratory diseases.  

    • Lowering blood pressure: In combination with Bifidobacterium lactis In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , L . rhamnosus therefore has a positive effect on blood pressure when taken over a longer period.  

    • Help with diarrhea: Several studies, both in children and adults, indicate an improvement in the duration and symptoms of diarrhea for various causes. Children infected with rotavirus had an improvement in the symptoms of diarrhea caused by L. rhamnosus had a lower risk of suffering from diarrhea symptoms lasting more than one week. Diarrhea is a major problem, especially during antibiotic treatment, but the risk has been reduced in adults with L . rhamnosus as a probiotic. Scientists therefore believe that the frequency, duration, and severity of diarrhea caused by L. rhamnosus can be reduced. The European Food Safety Authority confirms this after testing However, this was not the case in 2013 , so it cannot be said with certainty but is a guess .  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Positive influence on the gut-brain axis : It has recently been discovered that gut health influences the brain, as both influence each other through the gut-brain axis. In mice, L. rhamnosus positive influence on these by alleviating noise-induced cognitive deficits and because when taken at a young age, the offspring showed less anxious behavior .  

    • Insulin resistance: In a study on mice, L . rhamnsosus to regulate blood sugar by reducing insulin resistance. Additionally, they also showed lower weight gain compared to control mice.  

    • Lactose intolerance: A study showed that L . rhamnosus together with Bifidobacterium longum and vitamin B6, alleviated symptoms associated with lactose intolerance. These probiotics led to fewer constipation and bloating symptoms in the subjects.  

    • Liver-protective: Together with inosine , L. rhamnosus ameliorated alcohol-induced liver damage in mice .  

    • Atherosclerosis: By influencing fatty acid and ketone body metabolism , L. rhamnosus slowed the progression of atherosclerosis in an animal study.  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus rhamnosus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day. For specific applications, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.   

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNature , we 've also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics like Lactobacillus rhamnosus , for maximum effect. Our product SynbioticAgil also contains the prebiotic inulin.  

    Dangers of taking  

    The consumption of Lactobacillus rhamnosus strains, marketed as probiotics, is considered safe. However, in rare cases, it can lead to sepsis in certain at-risk groups. People with weak immune systems and infants are considered at risk and should therefore avoid taking them.  

     

    Which AgilNature ® products contain Lactobacillus rhamnosus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    6 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. GW Tannock, K. Munro et al.: Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. In: Applied and environmental microbiology. Volume 66, Number 6, June 2000, pp. 2578–2588, ISSN 0099-2240. 

    1. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017; 6(4):21. 

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Guandalini , Stefano; Pensabene, Licia; Zikri, Mona Abu*; Dias, Jorge Amil†; Casali, Luigi Gobio‡; Hoekstra, Hans§; Kolacek, Sanja÷; Massar, Karin§; Micetic –Turk, Dusanka; Papadopoulou, Alexandra#; de Sousa, Jaime Salazar**; Sandhu, Bhupinder††; Szajewska , Hanna‡‡; Weizman, Zvi§§. Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial. Journal of Pediatric Gastroenterology and Nutrition 30(1 ):p 54-60, January 2000. 

    1. Österlund, P., Ruotsalainen, T., Korpela, R. et al. Lactobacillus supplementation for diarrhea related to chemotherapy of colorectal cancer: a randomized study. Br J Cancer 97, 1028–1034 (2007). 

    1. Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persistent Functional Gastrointestinal Symptoms: A Randomized , Double-Blind, Cross-Over Study. Nutrients. 2019 Apr 19;11(4):886. 

    1. Arellano-García L, Macarulla MT, Cuevas-Sierra A, Martínez JA, Portillo MP, Milton- Laskibar I. Lactobacillus rhamnosus GG administration partially prevents diet-induced insulin resistance in rats: a comparison with its heat-inactivated parabiotic. Food Function . 2023 Oct 2;14(19):8865-8875. 

    1. Sapra L, Saini C, Das S, Mishra PK, Singh A, Mridha AR, Yadav PK, Srivastava RK. Lactobacillus rhamnosus (LR) ameliorates pulmonary and extrapulmonary acute respiratory distress syndrome (ARDS) via targeting neutrophils. Clin Immunol. 2024 Jan;258:109872 . 

    1. Kumpu , M., Kekkonen, R., Kautiainen , H. et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 66, 1020–1023 (2012). 

    1. Kara SS, Volkan B, Erten I. Lactobacillus rhamnosus GG can protect malnourished children. Benef Microbes. 2019 Apr 19;10(3):237-244. 

    1. Guo M , Liu H, Yu Y , Zhu Good Microbes. 2023 Jan-Dec;15(1):2190304 . 

    1. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023 Jul;228(4):152415. 

    1. Tong L, Zhang X, Hao H , Liu Q, Zhou Z, Liang Nutrients. 2021 Sep 23;13(10):3319 . 

    1. Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr . 2000 Feb;83(2):167-76. 

    1. Chen L, Li S, Peng C, Gui Q, Li J, Xu Z, Yang Y. Lactobacillus rhamnosus GG Promotes Recovery of the Colon Barrier in Septic Mice through Accelerating ISCs Regeneration. Nutrients. 2023 Jan 28;15(3):672. 

    1.  Gu Y, Qin X, Zhou G, Wang C, Mu C, Liu X, Zhong W , Xu Food Function . 2022 Nov 28;13(23):12144-12155. 

    1. Li X , Zheng P , Cao W, Cao Y, She X, Yang H, Ma K, Wu F , Gao Front Cell Infect Microbiol . 2023 Apr 26;13:1067367 . 

    1. Zhou B, Jin G, Pang X, Mo Q, Bao J, Liu T, Wu J, Xie R, Liu X, Liu J, Yang H , Xu Pharmacol Res. 2022 Mar;177:106090 . 

    1. Zhai T, Ren W, Wang P, Zheng L. Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis. Appl Microbiol Biotechnol . 2022 Dec;106(24):8233-8243 . 

    1. Zhu Y , Wang​ Toxicol Appl Pharmacol . 2022 Mar 15;439:115923 . 

    1. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło -Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. 

    1. Boggio Marzet C, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr . 2022 Feb;120(1 ):e 1-e7. English, Spanish. 

    1. Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for physicians. J Microbiol Immunol Infect. 2021 Aug;54(4):575-580. 

    1. Zhang B, Lynch B, Zhao J, Guo Y, Mak A. Lactobacillus rhamnosus MP108: Toxicological evaluation. J Food Sci. 2021 Jan;86(1):228-241. 

  • Lactobacillus paracasei
    Agil Nature

    Lactobacillus paracasei

    Overview :  

    Lactobacillus paracasei , is a gram-positive lactic acid bacterium of the family Lact obacillac eae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus paracasei finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines . As a probiotic, L. paracasei especially found in fermented vegetables or dairy products such as kefir. L. paracasei survives the gastrointestinal tract well and can survive there for up to 3 days.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Supports dental health: Streptococcus mutans is the primary bacterium responsible for caries formation. L. paracasei demonstrated inhibitory activity against this bacterium by attaching to it and causing it to clump together. This prevents S. mutans from adhering to the tooth and allows it to be washed away with saliva or when brushing.  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. paracasei promotes a It promotes a healthier balance in the intestines and increases the diversity of the intestinal flora. Likewise, the concentration of healthy, short-chain fatty acids in the intestines increases. Therefore, L. paracasei may be helpful in motility disorders of the gastrointestinal tract.  

    • Inhibits pathogens : L. paracasei inhibits the growth of certain pathogens such as E. coli , which is often associated with diarrhea .  

    • Weight control: Through its positive impact on intestinal health , L. paracsaei also positively influences weight. L. paracasei exhibits anti-obesity properties, alleviating obesity in mice by influencing fatty acid metabolism. In the study, 10 weeks of supplementation with the probiotic showed similar results to treatment with drugs such as orlistat .  

    • Immune system regulation: It is believed that L. paracasei can have a positive effect on the immune system and could have a supportive or preventative effect in diseases . For example, against viral infections, where an infection with the influenza virus could be better managed in mice . The potential of L. paracasei to improve resistance to common cold infections was also shown in test subjects . It is also used in allergy-related inflammation of the nasal mucosa . L. paracasei a positive influence is suspected.  

    • Cardiometabolic benefits: Supplementation with L. paracasei demonstrated positive effects on several cardiometabolic risk factors, including a reduction in cholesterol levels, which was associated with improved endothelial function by up to 5% in subjects. Furthermore, 12 weeks of supplementation also showed an improvement in metabolic syndrome (symptoms such as obesity, hypertension , and impaired glucose and lipid metabolism) , as both a reduced severity and a lower frequency of the syndrome were observed in subjects.  

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium longum half L. paracasei Subjects after 8 weeks of use , to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life by Relief of gastrointestinal symptoms and improvement of psychological well -being .  

    • Bone health : Ovariectomy (OOP) and postmenopause are associated with osteoporosis, which is a loss of bone density and increases the risk of bone fractures. Studies have shown that L. paracasei reduces bone loss in oophorectomy by reducing inflammation, thus offering hope as a treatment or preventative method for postmenopausal osteoporosis.  

    • Hyperuricemia: Hyperuricemia, which is an elevated level of uric acid in the blood that can lead to gout, causes an imbalance in the intestinal flora by increasing pathogenic bacteria and decreasing diversity. L. paracasei was shown to repair precisely this imbalance in experiments, reversing organ damage and alleviating inflammatory symptoms in hyperuricemia mice .  

    The optimal dosage of Lactobacillus paracasei can vary depending on individual health status and desired effect. Generally, dosages in supplements range from 1 to 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus paracasei , to ensure the best possible effect. Our product, SynbioticAgil, contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus paracasei is considered safe , even for the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus paracasei ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    7.17 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Chen JF, Hsia KC, Kuo YW, Chen SH, Huang YY, Li CM, Hsu YC, Tsai SY, Ho HH. Safety Assessment and Probiotic Potential Comparison of Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus plantarum LPL28, Lactobacillus acidophilus TYCA06, and Lactobacillus paracasei ET-66. Nutrients. 2023 Dec 29;16(1):126 . 

    1. Radicioni M, Koirala R, Fiore W, Leuratti C, Guglielmetti S, Arioli S. Survival of L. casei DG® (Lactobacillus paracasei CNCMI1572) in the gastrointestinal tract of a healthy pediatric population. Eur J Nutr . 2019 Dec;58(8):3161-3170. 

    1. Dehghani Champiri I, Bamzadeh Z, Rahimi E, Rouhi L. Lacticaseibacillus paracasei LB12, a Potential Probiotic Isolated from Traditional Iranian Fermented Milk ( Doogh ). Curr Microbiol . 2023 Sep 2;80(10):333. 

    1. Zhao Z, Wu J, Sun Z, Fan J, Liu F, Zhao W, Liu WH, Zhang M, Hung WL. Postbiotics Derived from L. paracasei ET-22 Inhibit the Formation of S. mutans Biofilms and Bioactive Substances : An Analysis. Molecules . 2023 Jan 27;28(3):1236 . 

    1. A Caridi, Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei , Journal of Industrial Microbiology and Biotechnology, Volume 29, Issue 6, 1 December 2002, Pages 303–308. 

    1. Cao J, Liu Q, Hao H, Bu Y, Tian X, Wang T, Yi H. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice. Front Immunol. 2022 Jul 6;13:940228 . 

    1. Cheng S, Li H, Ding Y, Huo J, Zheng Y, Jiang Y, Zhang Y, Man C. The Probiotic Combination of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 Alleviates Gastrointestinal Motility Disorder via Improving Gut Microbiota. Nutrients. 2023 Feb 7;15(4):839 . 

    1. Shin YJ, Bae JM, Cho HR, Mahoro P, Kim HH, Kim SH, Kim TH, Bae MJ. Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei , L. casei 431 on High-Fat Diet-Induced Obese Rats. J Med Food. 2023 Jul;26(7):445-453 . 

    1. Yang J, Huang J, Huang Z, Xu Y, Li W, Zhu S, Zhao Y, Ye B, Liu L, Zhu J, Xia M, Liu Y. Cardiometabolic benefits of Lacticaseibacillus paracasei 8700:2: A randomized double-blind placebo-controlled trial. Clin Nutr . 2023 Sep;42(9):1637-1646. 

    1. Kim S, Lee S, Kim TY, Lee SH, Seo SU, Kweon MN. Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection. Microbiomes. 2023 Nov 23;11(1):260. 

    1. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel- Higounenc I, Guéniche A. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defenses . Benef Microbes. 2014 Jun 1;5(2):129-36 . 

    1. Güvenç IA, Muluk NB, Mutlu FŞ, et al. Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis . American Journal of Rhinology & Allergy. 2016;30(5 ):e 157-e175. 

    1. Murata M, Kondo J, Iwabuchi N, Takahashi S, Yamauchi K, Abe F, Miura K. Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. Benef Microbes. 2018 Dec 7;9(6):855-864 . 

    1. Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl SH, Farman HH, Movérare-Skrtic S, Islander U, Sjögren K. Probiotics protect mice from ovariectomy-induced cortical bone loss . PLoS One . 2014 Mar 17;9(3 ):e 92368. 

    1. Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized , Placebo- Controlled Study. Nutrients . 2020 Apr 21;12(4):1159. 

  • Lactobacillus acidophilus
    Agil Nature

    Lactobacillus acidophilus

    Overview :  

    Lactobacillus acidophilus , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus acidophilus finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines, where it can break down bile acids. L. acidophilus is used as a probiotic. especially used in sour milk products , for example in yoghurts . Since L. acidophilus Because it prefers to live and be active at low pH levels , it survives the acids of the gastrointestinal tract well.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. acidophilus produces antibacterial peptides that are effective against potentially pathogenic bacteria such as Escherichia coli. Staphylococcus aureus and Salmonella enteritidis . In addition , L. acidophilus pH , which can also inhibit the growth of many pathogens in the gut, as some prefer a more neutral or alkaline environment. This promotes a healthy balance in the gut.  

    • Lowers cholesterol: In some experiments, L. acidophilus has shown cholesterol-lowering effects and an inhibitory effect on atherosclerosis , which can lead to heart attacks due to cholesterol deposits in the blood vessels. Therefore, a supply of L. acidophilus could reduce the risk of cardiovascular disease.  

    • Intestinal inflammation: Colitis is a chronic inflammation of the intestine that can be triggered by a disrupted intestinal barrier, an imbalanced intestinal flora, and genetic susceptibility. The main treatment for such intestinal inflammations is probiotics, and L. acidophilus has also proven helpful here. Thanks to the immunomodulatory properties of L. acidophilus , it reduces inflammatory reactions in the body. The protective function of the intestine has also been strengthened in studies with L. acidophilus .  

    • Help with diarrhea: In combination with other antibiotics , especially other Lactobacillus species and Bifidobacterium species , L. acidophilus the risk of diarrhea in young children from 32% to 20%.  

    • Weight control: By positively influencing intestinal imbalance and other factors, L. acidophilus Supplementation also improved weight loss in mice with obesity and associated diseases . Improvements in energy, sugar, and lipid metabolism were also observed in this regard .  

    • Immune system regulation: L. acidophilus shows positive effects on the immune response by influencing inflammatory processes and immune response in some pathogens such as the fungal infection Candida albicans .  

    • Cholesterol-lowering : Some laboratory and animal studies show significant reduction of serum cholesterol by L. acidophilus Addition . However, the experiments show differences among themselves, so the specific cholesterol-lowering effect is not yet fully understood from a scientific perspective.  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium animalis ssp . lactis helped L. acidophilus Subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, particularly through shorter and milder pain symptoms , as well as other symptom relief.  

    • Lactose intolerance: L. acidophilus Studies have shown improved lactose digestion and relieved symptoms such as bloating and diarrhea.  

    • Osteoporosis : Age , as well as postmenopause in women , can lead to this bone disease, which causes brittle bones due to porous bones . Its immunomodulatory effect was shown in a mouse study L. acidophilus administration may improve bone architecture and increase mineral density . By influencing the balance of certain immune cells, L. acidophilus as a probiotic, have an osteo-protective effect, especially for women with postmenopausal osteoporosis.  

    • Rheumatism: In rheumatoid Arthritis, or rheumatism for short, is an inflammatory joint disease associated with pain and stiffness. The inflammatory reactions can also have harmful effects on other organs. While the exact mechanisms are still unclear, experiments suggest that long-term use of L. acidophilus may help with arthritis by counteracting the inflammatory reactions in the body and thus protecting against more serious damage.  

    • Dermatitis: Due to the anti-inflammatory response that L. acidophilus could promote in the body , the probiotic improved the progression of dermatitis, a skin inflammatory disease, in a mouse model.  

    • ADHD: In a 3-month study in ADHD subjects aged 6-16, additional supplementation with L. acidophilus When taking the drug Amotextin , improvements in therapy such as in the concentration of children are observed .  

    • Liver cancer : Through the production of valeric acid by L. acidophilus , a suppression of the growth of liver cancer cells was observed in mice .  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus acidophilus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus acidophilus , to ensure the best possible effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus acidophilus is considered safe for health , even in the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus acidophilus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    4.41 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. SE Gilliland, ML Speck: Deconjugation of bile acids by intestinal lactobacilli. In: Applied and Environmental Microbiology. Volume 33, No. 1, 1977, ISSN 0099-2240, pp. 15-18, 

    1. Gao H, Li X, Chen X, Hai D, Wei C, Zhang L, Li P. The functional roles of Lactobacillus acidophilus in different physiological and pathological processes. J Microbiol Biotechnol . 2022 Oct 28;32(10):1226-1233. 

    1. Xing TL, Bian X, Ma CM, Yang Y, Liu Food Function . 2023 Mar 6;14(5):2472-2480. 

    1. Li P, Chen G, Zhang J, Pei C, Chen Y, Gong J, Deng S, Cai K, Li H, Wang D, Shen B, Xie Z, Liao Q. Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis. Food Function . 2022 Mar 7;13(5):2985-2997 . 

    1. Kye YJ, Lee SY, Kim HR, Lee BH, Park JH, Park MS, Ji GE, Sung MK. Lactobacillus acidophilus PIN7 paraprobiotic supplementation ameliorates DSS-induced colitis through anti-inflammatory and immune regulatory effects. J Appl Microbiol . 2022 Apr;132(4):3189-3200 . 

    1. Lukasik J, Dierikx T, Besseling -van der Vaart I, de Meij T, Szajewska H; Multispecies Probiotic in AAD Study Group. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatrics . 2022 Sep 1;176(9):860-866. 

    1. Skrzydło-Radomańska B, Prozorow -Król B, Cichoż -Lach H, Majsiak E, Bierła JB, Kosikowski W, Szczerbiński M, Gantzel J, Cukrowska B. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020 Jul 5;12(7):1999. 

    1. Li P, He Probiotics Antimicrob Proteins. 2023 Dec 5 . 

    1. Kang Y, Kang X , Yang H, Liu H, Yang X, Liu Q, Tian H, Xue Y, Ren P, Kuang Pharmacol Res. 2022 Jan;175:106020 . 

    1. Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, Choi JW, Park JS, Jhun J, Park SH, Cho ML. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023 Jun 14;21(1):135. 

    1. Lau HC, Zhang X, Ji F, Lin Y, Liang W, Li Q, Chen D, Fong W, Kang EBioMedicine . 2024 Feb;100:104952 . 

    1. Elhossiny RM, Elshahawy HH, Mohamed HM, Abdelmageed RI. Assessment of probiotic strain Lactobacillus acidophilus LB supplementation as adjunctive management of attention-deficit hyperactivity disorder in children and adolescents: a randomized controlled clinical trial. BMC Psychiatry. 2023 Nov 9;23(1):823 . 

    1. Paul AK, Paul A, Jahan R, Jannat K, Bondhon TA, Hasan A, Nissapatorn V, Pereira ML, Wilairatana P, Rahmatullah M. Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus. Microorganisms. 2021 May 16;9(5):1070 . 

    1. Amdekar S, Singh V, Kumar A, Sharma P, Singh R. Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines. Indian J Clin Biochem . 2014 Oct;29(4):471-8 . 

    1. Bungau SG, Behl T, Singh A, Sehgal A, Singh S, Chigurupati S, Vijayabalan S, Das S, Palanimuthu VR. Targeting Probiotics in Rheumatoid Arthritis. Nutrients. 2021 Sep 26;13(10):3376 . 

    1. Dar HY, Shukla P, Mishra PK, Anupam R, Mondal RK, Tomar GB, Sharma V, Srivastava RK. Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance. Bone Rep. 2018 Feb 5;8:46 -56 . 

    1. Kim WK, Jang YJ, Park S, Min SG, Kwon H, Jo MJ, Ko G. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. JMicrobiol .​ 2024 Feb;62(2):91-99 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

     

  • Lavendel
    Agil Nature

    Lavender

    Origin and history

    Lavender ( Lavandula officinalis ) probably originated in Persia and from there spread throughout the Mediterranean region. The bluish-purple flowering shrub grows primarily in southern France, Italy and Greece, but can also be found on the Canary Islands and North Africa. In addition to true lavender (Lavandula officinalis), there are numerous other species such as Lavandula angustifolia and lavandin (Lavandula x intermedia). Lavandula stoechas, also known as lavender, is characterized by its characteristic flower heads. Each type has its own scent and active ingredient profiles that make it ideal for different applications  

    Lavender was already used in ancient Egypt for its disinfecting and healing effects, for example in religious ceremonies. The Romans also used lavender to cleanse the body and clothing. So it is not surprising that lavender is derived from the Latin word “lavare”, which means “to wash”. In the Middle Ages, monks brought lavender from Italy across the Alps, where it was widely planted in monastery and farm gardens. Nowadays, cultivated lavender grows in almost all climate zones, but only grows wild in the Mediterranean region.  

     

     

    Lavender is probably the best-known natural remedy for restlessness, anxiety and stress due to its relaxing and calming effect. The active substances in lavender are found in the flowers, which contain essential oil and flavonoids. Lavender oil (especially the linalool and linalyl acetate it contains) can have a calming and sleep-inducing effect. Since, in addition to its calming properties, it is also said to be anti-flatulent and a cholagogue, it is also used to alleviate complaints such as inner restlessness, nervous exhaustion, difficulty falling asleep, migraines as well as nervous gastrointestinal and biliary problems. It has been found that lavender can be effective not only for stress-related sleep problems but also for cases of sleep disorders caused by caffeine.  

     

    In aromatherapy, inhaling lavender oil causes calming, increases relaxation, improves sleep and also improves mood. This can be particularly helpful for depressive moods. The antioxidant and pain-relieving effects of the oil have been proven in studies on migraine headaches. For people with sleep disorders, the use of lavender improves well-being, supports mental clarity and suppresses aggression and anxiety. Even with needle injections, lavender not only reduced the fear of the needle, but also slightly reduced the pain.  

     

    In addition, the plant's ingredients are considered anti-oxidant, which means they also have a neuroprotective function, and antibacterial.  

     

    Caution 

    Although lavender is generally considered safe, lavender oil should not be applied undiluted to the skin or taken internally 

     

    Other applications 

    Lavender is used in many ways, for example as a herb in the kitchen, tea, aromatic oil or in the form of nutritional supplements and medicines. In addition to its use as a medicinal plant, lavender is also often used as a moth repellent because the aroma is considered to repel insects. The dried flowers help against annoying moths in the wardrobe, for example.  

     

    Which AgilNature® products contain lavender?  

    Product 

    Crowd 

    NRV* 

    RelaxAgil nacht 

    100 mg per 1 capsule (daily ration) 

    ** 

     

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature:  

    1. "Lavender”. National Center for Complementary and Integrative Health, US National Institutes of Health. August 2020. https://www.nccih.nih.gov/health/lavender (Accessed January 21, 2024)
    2. Etheridge CJ, Mason P (2021) A Scientific Review of Selected Essential Oils and their Botanical Ingredients. Focus on Essential Oils used for Respiratory and Calming Indications. Arch Environ Sci Environ Toxicol 4:133.
    3. Harada H, Kashiwadani H, Kanmura Y, Kuwaki T. Linalool Odor-Induced Anxiolytic Effects in Mice. Front Behavior Neurosci. 2018 Oct 23;12:241.
    4. Ogata K, Ataka K, Suzuki H, Yagi T, Okawa A, Fukumoto T, Zhang B, Nakata M, Yada T, Asakawa A. Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study. Evid Based Complement Alternat Med. 2020 Jul 14;2020:5418586.
    5. Meneses C, Valdes-Gonzalez M, Garrido-Suárez BB, Garrido G. Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020. Phytother Res. 2023 May;37(5) :2144-2167.
    6. Diass K, Merzouki M, Elfazazi K, Azzouzi H, Challioui A, Azzaoui K, Hammouti B, Touzani R, Depeint F, Ayerdi Gotor A, Rhazi L. Essential Oil of Lavandula officinalis: Chemical Composition and Antibacterial Activities. Plants (Basel). 2023 Apr 6;12(7):1571.
    7. Babar Ali, Naser Ali Al-Wabel, Saiba Shams, Aftab Ahamad, Shah Alam Khan, Firoz Anwar, Essential oils used in aromatherapy: A review, Asian Pacific Journal of Tropical Biomedicine, Volume 5, Issue 8, 2015, Pages 601- 611, ISSN 2221-1691.
    8. Kim S, Kim HJ, Yeo JS, Hong SJ, Lee JM, Jeon Y. The effect of lavender oil on stress, bispectral index values, and needle insertion pain in volunteers. J Altern Complement Med. 2011;17:823–6.
    9. Xu Y, Ma L, Liu F, Yao L, Wang W, Yang S, Han T. Lavender essential oil fractions alleviate sleep disorders induced by the combination of anxiety and caffeine in mice. J Ethnopharmacol. 2023 Feb 10;302(Pt A):115868.
    10. Batiha, GE, Teibo, JO, Wasef, L., Shaheen, HM, Akomolafe, AP, Teibo, TKA, Al-Kuraishy, ​​HM, Al-Garbeeb, AI, Alexiou, A., & Papadakis, M. (2023) . A review of the bioactive components and pharmacological properties of Lavandula species. Naunyn-Schmiedeberg's archives of pharmacology, 396(5), 877–900.
  • Löwenzahnextrakt
    Agil Nature

    Dandelion extract

    Origin and history 

    The common dandelion ( Taraxacum sect. Ruderalia, formerly Taraxacum officinale ) is a plant known to everyone with the characteristic yellow flower that develops into a dandelion. Originally from Eurasia, the plant can now be found all over the world.  

    In symbolism, the dandelion often represents resilience and the ability to adapt to challenges. In some cultures it also symbolizes hope and wishes, which is reflected in the tradition of blowing the dandelion.  

    The benefits of this plant in traditional medicine have been common for over 2000 years, for example it is used as a diuretic in traditional Chinese medicine. In Arabic medicine it was even one of the first remedies for liver diseases.  

     

    Effects of dandelion

    The health-supporting, healing effects of Lion's Number are versatile because the extract of the plant contains a wide range of different active substances. It also contains high amounts of vitamin A and vitamin C, important minerals such as potassium, iron and calcium as well as fiber.  

    The phenols and flavonoids contained ensure effective anti-bacterial and anti-oxidative properties. The antioxidant property protects the cells in the body from stress that can lead to damage. In one study, bone cells were protected in this way and dandelion therefore offers a potential prevention of bone diseases caused by oxidative stress. It can also potentially serve as a preventive measure for other diseases caused by oxidative stress such as Alzheimer's and dementia.  

      

    It can also ensure the health of the cells in our body with its anti-tumor effect, which has been examined in several studies. Sometimes against a very aggressive type of breast cancer. Ingredients in the plant inhibit the growth of cancer cells and cause them to die.  

     

    Due to the anti-inflammatory effects of dandelion, it also creates a good basis for treating inflammation-related diseases such as tracheobronchitis. In addition, it may be a reason for the great potential of dandelion to protect the gastrointestinal tract and treat gastrointestinal diseases.  

     

    Lion's Number Extract was also shown to be effective in protecting against liver damage in mice. Since some studies have also found a reduction in blood sugar and insulin resistance, it can also be effective in preventing diabetes.  

    Regarding cardiovascular diseases, dandelion root extracts have been reported to have antiplatelet, hypolipidemic and antioxidant effects, which are beneficial in the treatment of cardiovascular diseases.  

     

     

    Possible side effects 

    A high potassium content in dandelions is likely responsible for the diuretic effect. If ingested, it can therefore lead to more frequent urination.  

     

    Because of its high mineral content, dandelion extract may interact with some antibiotics such as ciprofloxacin. Dandelion can cause the absorption of the antibiotic to be inhibited. This should be taken into account when taking together.  

     

    People with gallstones or severe biliary tract diseases, as well as those taking anticoagulants, should consult their doctor before taking dandelion, as interactions are possible.  

     

    Environmental friendliness  

    Dandelions are an adaptable plant that thrive in a variety of environments. It prefers sunny locations and well-drained soil. Dandelions contribute to biodiversity by providing food for pollinators such as bees.  

     

    Which AgilNature® products contain dandelion extract? 

    Product 

    Crowd 

    NRV* 

    DetoxAgil 

    150 mg per 6 capsules (daily ration) 

    * * 

     

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature:  

    Clare BA, Conroy RS, Spelman K. The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med. 2009 Aug;15(8):929-34.  

    Fan M, Zhang X, Song H, Zhang Y. Dandelion (Taraxacum Genus): A Review of Chemical Constituents and Pharmacological Effects. Molecules. 2023 Jun 27;28(13):5022.  

    Seo J.-E., Kim G.-H. Antioxidant Activity and Differentiation Effect of Taraxacum mongolicum Extracts against Hydrogen Peroxide-induced Oxidative Damage of MC3T3-E1 Osteoblast Cells. Korean J. Food Cook. Sci. 2012;28:311–318.  

    Wang S, Hao HF, Jiao YN, Fu JL, Guo ZW, Guo Y, Yuan Y, Li PP, Han SY. Dandelion extract inhibits triple-negative breast cancer cell proliferation by interfering with glycerophospholipids and unsaturated fatty acids metabolism. Front Pharmacol. 2022 Sep 6;13:942996.  

    Li Y, Deng Y, Zhang X, Fu H, Han X, Guo W, Zhao W, Zhao Squamous Cell Carcinoma. Front Pharmacol. 2022 May 20;13:897465.  

    Chen Y, Fei S, Yu X, Tan M. Dandelion (Taraxacum mongolicum) Extract Alleviated H2O2-Induced Oxidative Damage: The Underlying Mechanism Revealed by Metabolomics and Lipidomics. Foods. 2023 Sep 3;12(17):3314.  

    Hwang KH, Park TK The inhibitory activity of the Taraxacum mongolicum on monoamine oxidase. Korean J. Pharmacogn. 2006;37:229–234.  

    Li W, Luo F, Wu X, Fan B, Yang M, Zhong W, Guan D, Wang F, Wang Q. Anti-inflammatory effects and mechanisms of Dandelion in RAW264.7 Macrophages and Zebrafish Larvae. Front Pharmacol. 2022 Aug 25;13:906927.  

    Li Y, Chen Y, Sun-Waterhouse D. The potential of dandelion in the fight against gastrointestinal diseases: A review. J Ethnopharmacol. 2022 Jul 15;293:115272.  

    Zheng Y, Lei L, Liang S, Ai J, Deng X, Li YQ, Zhang TP, Pu SB, Ren YS. Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury. Chin J Integr Med. 2022 Aug;28(8):683-692.  

    Ignat MV, Coldea TE, Salanță LC, Mudura E. Plants of the Spontaneous Flora with Beneficial Action in the Management of Diabetes, Hepatic Disorders, and Cardiovascular Disease. Plants (Basel). 2021 Jan 23;10(2):216.  

    Zhu M, Wong PY, Li RC. Effects of taraxacum mongolicum on the bioavailability and disposition of ciprofloxacin in rats. J Pharm Sci. 1999 Jun;88(6):632-4  

  • Lapacho AgilNature
    Agil Nature

    Lapacho

    Origin of Lapacho tea

     
     

    Lapacho tea consists of the inner bark of the Lapacho tree, which is peeled off and grated once or twice a year. The lapacho tree (Tabebuia avellaneda or Tabebuia impetiiginosa) is found across much of South and Central America. There are dozens of regional subspecies of this plant. It is very adaptable, robust and relatively undemanding.

     

     
     

    taste

     
     
     
    (Lapacho - the traditional natural remedy of the Indians)

    The infusion from the Lapacho bark is very tasty, pleasantly smoky, reminiscent of vanilla and a little bit of cinnamon.

     

     
     

    Lapacho tea and its effects

    It has been proven that Lapacho tea contains many vitamins, minerals and plant substances such as calcium, potassium and iron as well as - in addition to the bioactive substance 'lapachol' - also trace elements such as barium, strontium, iodine and boron. Lapacho tea has an antibacterial and diuretic effect , antifungal and anti-inflammatory.

    Lapacho tea is used as a medicinal and pleasure tea, especially for many chronic problems.

     

     
     

    Which AgilNature® products contain Lapacho?

    Product
    DetoxAgil Tea - The herbal mixture for a feeling of lightness

     

     

    Literature:

    Lübeck, Walter: Healing with Lapacho tea, the healing power of the "divine tree", wind horse.