6 articles Found
  • Agil Nature

    Bifidobacterium lactis

    Bifidobacterium lactis , also Bifidobacterium animalis ssp . lactis , is a gram-positive lactic acid bacterium of the family Bifidobacteriaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Bifidobacterium animalis ssp . lactis finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . B. lactis is in abundant products used, mainly in dairy products . For example , it is also used in some yogurts in Lidl , listed as " Bifidobacterium BB-12" or in the prominent probiotic Activia yogurts. It is believed that B. lactis the gastrointestinal passage survived well and also has the potential to colonize the intestinal flora over a longer period of time . When taken with inulin, a concomitant dietary fiber, B. lactis was found in stool samples even two weeks after ingestion, indicating successful , long-term colonization in the intestine .  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Provides digestive support: B. lactis Helps digest fiber and plant substances . Since they are not among the bacteria that produce gas during digestion, they can divert fermentation in the large intestine to a non-gaseous end product and thus reduce potential flatulence. In a study on elderly people who consumed 1 x 10 9 CFU/day of B. lactis ( our SynbioticAgil contains 6 times that amount!) , more regular bowel movements were found on 26.9% of days . The number of test subjects who had normal bowel movements on more than 30% of days increased by 114% .  

    • Help with diarrhea: In addition to helping with constipation, A prominent feature of B. lactis is its ability to help with diarrhea. Especially in the elderly , but also in young children and those with antibiotic-associated problems, B. lactis helped to normalize bowel movements. In patients who underwent a 14-day antibiotic therapy and B. lactis income, the strength and risk possible diarrhea symptoms . The risk decreased to 10.8%, compared to the control group, which had a 15.56% risk. The duration also decreased to approximately 2 days instead of 4.  

    • Promotes intestinal health: An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. This imbalance is believed to be related to obesity and weight regulation. B. lactis promotes a healthy balance in the gut and supports its protective function. This keeps bacteria in the gut and reduces the risk of inflammation. According to a study, B. lactis as a probiotic, the intestinal flora of overweight subjects is adapted to the intestinal flora composition that is usually associated with a slimmer phenotype .  

    • Weight control: Through its positive influence on intestinal health , B. lactis also positively influences weight. Supplementation with B. lactis According to studies, it leads to a significant reduction in total body fat mass , food intake , and waist circumference. Fat deposits are particularly reduced in the abdominal area. This is also reflected in the BMI, which was reduced with long-term consumption of B. lactis . Studies assume that fat deposits are reduced due to the positive influence of B. lactis on fatty acid metabolism.  

    • Immune system regulation: It is suspected that B. lactis can help regulate the immune response against pathogens. Laboratory experiments have shown an improvement in the immune response against pathogens such as S. typhimurium , which is often involved in food poisoning due to poor food hygiene. B. lactis has also been shown to be effective against oxidative stress . helpful in rats .  

    • Respiratory symptoms of colds : Studies on toddlers and schoolchildren suggest that B. lactis could help increase the organism's resistance to common infections by strengthening the immune system . According to the studies , B. lactis also reduce the frequency and duration of respiratory infections.  

    • Lowering blood pressure: In combination with Lactobacillus rhamnosus In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , B. lactis may therefore have a positive effect on blood pressure when taken over a longer period of time.  

    • Baby colic: Known as baby colic , or three-month colic , is a period in which babies cry excessively, thought to be caused by abdominal pain , which may be related to the microbiome in the gut. Giving babies B. lactis halved the risk of colic in 80 percent of cases. the length of crying phases. The babies' stools also improved. ( Even though B. lactis is considered beneficial for children and babies, you should consult a doctor before taking it .)  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Type 1 diabetes : According to one study, a six-month supplementation of a mixture of different probiotics, including B. lactis , with concomitant insulin therapy helped improve insulin therapy. Conventional insulin therapy plus probiotics reduced diabetes symptoms by better stabilizing blood sugar levels and lowering HbA1c levels . It's important to note that probiotics are by no means a substitute for insulin therapy, but the right probiotics can potentially enhance it!  

    • Women's health : Together with other probiotics in the mix, B. lactis A positive effect on vascular function and arterial stiffness in overweight postmenopausal women was also shown . In addition, an improvement in bone metabolism was observed in postmenopausal osteoporosis with reduced inflammation.  

    • Coronary heart disease: The simultaneous Taking B.lactis with a conventional therapy regimen ( with atorvastatin and Metoprolol ) is thought to offer additional benefits compared to conventional treatment alone, for example by increasing anti-inflammatory microbial species in the gut , modulating the concentration of certain biological metabolites and more.  

    • Supports fat metabolism and sports performance : An 8-week course of B. lactis supplementation combined with exercise training showed positive changes in fatty acid metabolism in ski athletes . Concentrations of triglycerides, LDL-C, and bile acids were reduced, accompanied by a significant increase in short-chain fatty acids, which are considered healthy for the body. This was also accompanied by improved muscle strength and oxygen uptake during endurance exercise.  

    • Irritable bowel syndrome: Together with Lactobacillus acidophilus , B. lactis subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, especially through shorter and milder pain symptoms.  

    • Alzheimer's: One of the main triggers for Alzheimer's is beta-amyloid plaques in the brain. In a 6-week study on mice, it was found that taking B. lactis reduced beta-amyloid plaque burden throughout the brain . Additionally, a preventive effect on improving working memory was observed.  

    Recommended dosages and instructions for use  

    The optimal dosage of Bifidobac terium lactis may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    We at AgilNatur e have in our “ SynbioticAgil ” product that provides you with probiotics such as Bifidobacterium lactis , we also take care of prebiotics to achieve the best effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Bifidobacterium Lactis is considered safe for health , even in the elderly and children . However, some probiotics can rarely cause sepsis in certain at-risk groups. People with weak immune systems and babies are considered at-risk and should therefore avoid taking it without consulting a doctor.  

     

    Which AgilNature ® products contain Bifidobacterium lactis ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    5.9 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020 Mar 25;12(4):892. 

    1. Stenman, LK, Lehtinen, MJ, Meland, N., Christensen, JE, Yeung, N., Saarinen, MT, Courtney, M., Burcelin , R., Lähdeaho , M.-L., Linros , J., Apter, D., Scheinin , M., Smerud, HK, Rissanen, A. & Lahtinen, S. (2016). Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin , in Overweight and Obese Adults—Randomized Controlled Trial. EBioMedicine , 13, 190–200. 

    1. Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla -Pagà L, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, Ramón D, Arola L, Solà R. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2019 Sep;43(9):1863-1868. 

    1. Balaguer F, Enrique M, Llopis S, Barrena M, Navarro V, Álvarez B, Chenoll E, Ramón D, Tortajada M, Martorell P. Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF-1 pathway. Microb Biotechnol . 2022 Mar;15(3):805-816 . 

    1. Ban OH, Lee M, Bang WY, Nam EH, Jeon HJ, Shin M, Yang J, Jung YH. Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism. Mol Nutr Food Res. 2023 Feb;67(3 ):e 2200385. 

    1. Cheng J, Laitila A, Ouwehand AC. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review. Front Nutr . 2021 Dec 14;8:790561 . 

    1. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. 

    1. Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, Michels C, Madeira K, Voytena AP, Rossetto M, Ramlov F, de Castro Damásio D, Dal-Pizzol F. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023 Jun;15(3):738-748. 

    1. Xu B, Liang S, Zhao J, Li X, Guo J, Xin B, Li B, Huo G, Ma W. Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Function . 2022 Jun 6;13(11):6404-6418 . 

    1. Vitheejongjaroen P, Kasorn A, Puttarat N, Loison F, Taweechotipatr M. Bifidobacterium animalis MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats. Antioxidants (Basel). 2022 Oct 29;11(11):2146. 

    1. Nocerino R, De Filippis F, Cecere G, Marino A, Micillo M, Di Scala C, de Caro C, Calignano A, Bruno C, Paparo L, Iannicelli AM, Cosenza L, Maddalena Y, Della Gatta G, Coppola S, Carucci L, Ercolini D, Berni Canani R. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomized , double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan;51(1):110-120. 

    1. Wang, CH, Yen, HR, Lu, WL, Ho, HH, Lin, WY, Kuo, YW, Huang, YY, Tsai, SY, & Lin, HC (2022). Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Frontiers in endocrinology, 13, 754401. 

    1. Siddiqui R, Makhlouf Z, Alharbi AM, Alfahemi H, Khan NA. The Gut Microbiome and Female Health. Biology (Basel). 2022 Nov 21;11(11):1683 . 

    1. Sun B, Ma T, Li Y, Yang N, Li B, Zhou mSystems . 2022 Apr 26;7(2 ):e 0010022. 

    1. Li T, Rui Z, Mao L, Chang Y, Shao J, Chen Y, Han Q, Sui Nutrients. 2023 Oct 27;15(21):4554 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

    1. Zhao F, Guo Z, Kwok LY, Zhao Z, Wang K, Li Y, Sun Z, Zhao J, Zhang H. Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota. Eur J Nutr . 2023 Mar;62(2):965-976. 

    1. Cao J, Amakye WK, Qi C, Liu X, Ma J, Ren J. Bifidobacterium Lactis Probio-M8 regulates gut microbiota to alleviate Alzheimer's disease in the APP/PS1 mouse model. Eur J Nutr . 2021 Oct;60(7):3757-3769. 

    1. Tsai HY, Wang YC, Liao CA, Su CY, Huang CH, Chiu MH, Yeh YT. Safety and the probiotic potential of Bifidobacterium animalis CP-9. J Food Sci. 2022 May;87(5):2211-2228 . 

  • Agil Nature

    Nettle

    Origin and history

    The genus of stinging nettles ( Urtica ) includes up to 70 species worldwide. The most noticeable feature is the stinging hairs on the plant, which can cause painful swelling on the skin when touched. Nevertheless, people have not avoided the plant since early times and have made use of it. In the Bronze Age, in some regions, nettle fibers were used to make clothing, for example. Even today the majority is grown as a fiber crop. The plant is also found in many different folklore and traditional dishes around the world. It also has a long history of use as a medicinal plant, giving rise to many superstitions and customs.  

    Characteristics  

    In addition to its pleasant, slightly sour taste, nettle has many nutrients in dishes such as a high content of flavonoids, magnesium, potassium, silicon, vitamins A & C and proteins. In fact, the plant contains about twice as much vitamin C as oranges and up to 30% of the dry matter consists of proteins.  

    The medicinal uses and health benefits of the plant are very diverse. The nettle detoxifies, promotes and stimulates the metabolism. Properties and effects that are known and have been investigated in studies are:  

    - Influence on the central nervous system:  

    The components of nettle have a neuroprotective effect and can ensure the survival of brain cells. In addition, they protect against damage thanks to their antioxidant effect. A study suggests that nettle also has a positive effect on learning performance. In mice, administration of nettle extract showed an antidepressant effect, which is also suspected to have potential in stress-induced neurological diseases.  

    - Influence on the cardiovascular system:  

    Due to its vasodilating effect, nettle extract can reduce heart rate and blood pressure, which can be beneficial if you have high blood pressure. The flavonoids it contains counteract the formation of blood clots in the vessels, which can otherwise lead to thrombosis or strokes. The knowledge obtained from studies supports the traditional benefits of the plant in the prevention and/or treatment of cardiovascular diseases.  

    - Influence on the immune system:  

    Nettle contents have been shown to be anti-inflammatory and immune stimulating. It also has an inhibitory effect on neuronal inflammation, which contributes to its neuroprotective properties. In addition, antimicrobial, antifungal and, for some viruses, antiviral effects have also been found.  

    - Influence on metabolic syndrome:  

    Metabolic syndrome describes a group of symptoms that occur together. These include obesity, high blood pressure and disorders of sugar and fat metabolism. Studies on diabetic mice have shown that nettle lowers blood sugar, stimulates insulin secretion and thus increases insulin levels in the blood and can counteract insulin resistance. It therefore offers a promising approach as a treatment option for diabetes.  

    It is also effective for elevated blood lipid levels. Nettle lowers the cholesterol content in the blood. It lowers LDL cholesterol, which is considered “unhealthy,” and increases healthy HDL cholesterol. It is therefore also helpful in terms of fat metabolism.  

    - Influence on the digestive system:  

    Prolonged use of nettles provides a protective measure against chronic colitis. But for existing chronic illnesses such as IBD, nettle has a positive effect due to the plant's immune-modulating effect.  

    - Anti-cancer effect:  

    In studies of prostate cancer as well as breast cancer, anti-tumor properties of stinging nettle have been found. They inhibit cancer cell growth and also offer protection against cancer formation. The active ingredients of nettle had a chemopreventive and anti-mutagenic effect when mice were exposed to carcinogens.  

    In experiments, it was found that nettle extract (more specifically Urtica dioica ) increased the sensitivity of breast cancer cells to treatments with cisplatin and also paclitaxel. When treating breast cancer, additional nettle intake could have a positive effect on the treatment. In addition, the extract has the potential to counteract side effects such as liver and kidney damage from cisplatin treatment .  

    - Organ protective:  

    Nettle has an antioxidant effect. This enables protection of organs and diseases associated with them. Organs sometimes include the brain, liver, lungs, kidneys, ovaries and uterus.  

    - Pain-relieving effect (also for rheumatic diseases)  

    - Potential help with hair loss  

    - Supports wound healing  

     

    Possible side effects  

    Due to the heartbeat and blood pressure lowering effects of nettle, high consumption of the plant is not recommended.  

    Due to the influence on blood sugar and pressure, a dangerous interaction should be ruled out when taking appropriate medication and seek advice from a doctor. People taking blood thinners or medications to control blood pressure should also exercise caution, as nettles can affect the effects of these medications.  

      

    Nettle also causes more frequent urination.  

    Although nettle is said to have an abortifacient effect and an influence on the menstrual cycle in traditional medicine, oral administration of 250 mg/kg of nettle to mice shows no abortifacient effect. However, there is still a lack of clear evidence against the abortifacient effect, so nettle intake should be completely avoided during pregnancy or in breastfeeding women and children.  

     

    Interactions  

    Possible interactions of stinging nettle with medications for rheumatoid arthritis, increased blood sugar and pressure, and depression as well as sedatives are possible. Therefore, taking them together is not recommended or prior advice is recommended.  

     

    Which AgilNature® products contain nettle powder? 

    Product 

    Crowd 

    NRV* 

    DetoxAgil  

    300 mg per daily ration (6 capsules each) 

    **  

     

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature:  

    1. Randall, Colin (2004). Kavalali, Gulsel M (ed.). Historical and modern uses of Urtica (pages 12-14). In: Urtica: The genus Urtica. CRC Press, Inc. pp. 12–14. ISBN 0203017927.  
    2. Wolska J, Czop M, Jakubczyk K, Janda K: Influence of temperature and brewing time of nettle (Urtica dioica L.) infusions on vitamin C content. Rocz Panstw Zakl Hig. 2016;67(4):367-371  
    3. Jerzy Lutomski, Henryk Speichert: The stinging nettle in medicine and nutrition. In: Pharmacy in our time. Volume 12, No. 6, 1983, pp. 181-186.  
    4. Dhouibi R, Affes H, Ben Salem M, Hammami S, Sahnoun Z, Zeghal KM, Ksouda K. Screening of pharmacological uses of Urtica dioica and other benefits. Prog Biophys Mol Biol. 2020 Jan;150:67-77.  
    5. Semwal P, Rauf A, Olatunde A, Singh P, Zaky MY, Islam MM, Khalil AA, Aljohani ASM, Al Abdulmonem W, Ribaudo G. The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity . Nat Prod Bioprospect. 2023 May 12;13(1):16.  
    6. Devkota HP, Paudel KR, Khanal S, Baral A, Panth N, Adhikari-Devkota A, Jha NK, Das N, Singh SK, Chellappan DK, Dua K, Hansbro PM. Stinging Nettle (Urtica dioica L.): Nutritional Composition, Bioactive Compounds, and Food Functional Properties. Molecules. 2022 Aug 16;27(16):5219.  
    7. Taheri Y, Quispe C, Herrera-Bravo J, Sharifi-Rad J, Ezzat SM, Merghany RM, Shaheen S, Azmi L, Prakash Mishra A, Sener B, Kılıç M, Sen S, Acharya K, Nasiri A, Cruz-Martins N, Tsouh Fokou PV, Ydyrys A, Bassygarayev Z, Daştan SD, Alshehri MM, Calina D, Cho WC. Urtica dioica-Derived Phytochemicals for Pharmacological and Therapeutic Applications. Evid Based Complement Alternat Med. 2022 Feb 24;2022:4024331.  
    8. Zamani-Garmsiri F, Akmali M, Gohari A, Zal F, Seghatoleslam A. Urtica dioica (Gazaneh) distillate restores glucose metabolism in diabetic rats. Int J Prev Med. 2023 May 27;14:68.  
    9. Samakar B, Mehri S, Hosseinzadeh H. A review of the effects of Urtica dioica (nettle) in metabolic syndrome. Iran J Basic Med Sci. 2022 May;25(5):543-553.  
    10. Nafeh G, Abi Akl M, Samarani J, Bahous R, Al Kari G, Younes M, Sarkis R, Rizk S. Urtica dioica Leaf Infusion Enhances the Sensitivity of Triple-Negative Breast Cancer Cells to Cisplatin Treatment. Pharmaceuticals (Basel). 2023 May 23;16(6):780.  
    11. Karakol P, Saraydin SU, Bozkurt M, Hepokur C, Inan ZDS, Turan M. Anticancer Effects of Urtica Dioica in Breast Cancer. Asian Pac J Cancer Prev. 2022 Feb 1;23(2):673-681.  
    12. Esposito S, Bianco A, Russo R, Di Maro A, Isernia C, Pedone PV. Therapeutic Perspectives of Molecules from Urtica dioica Extracts for Cancer Treatment. Molecules. 2019 Jul 29;24(15):2753.  
    13. Jaiswal V, Lee HJ. Antioxidant Activity of Urtica dioica: An Important Property Contributing to Multiple Biological Activities. Antioxidants (Basel). 2022 Dec 19;11(12):2494.  
    14. Gasmi A, Mujawdiya PK, Beley N, Shanaida M, Lysiuk R, Lenchyk L, Noor S, Muhammad A, Strus O, Piscopo S, Komisarenko A, Fedorovska M, Bjørklund G. Natural Compounds Used for Treating Hair Loss. Curr Pharm Des. 2023;29(16):1231-1244.  
    15. Kasouni AI, Chatzimitakos TG, Stalikas CD, Trangas T, Papoudou-Bai A, Troganis AN. The Unexplored Wound Healing Activity of Urtica dioica L. Extract: An In Vitro and In Vivo Study. Molecules. 2021 Oct 15;26(20):6248.  
  • Agil Nature

    Bacillus coagulans

    Bacillus coagulans , formerly incorrectly referred to as Lactobacillus sporogenes , is a gram-positive bacterium of the family Bacillaceae that has the ability to form spores . The spores allow it to multiply in the intestines for a certain period of time and thus show its effect for longer . It is generally considered safe by the FDA.  

    What is Bacillus Coagulans for

    Bacillus coagulans is used as a probiotic. Probiotics are living microorganisms that, in certain quantities, offer health benefits. Thanks to its ability to form spores, it has a better chance of survival than other traditional probiotics such as Lactobacillus for example. The beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic are:  

    • Digestive aid: B. coagulans produces various enzymes that help us with digestion and bowel movements. Sometimes enzymes that can digest lactose, so that lactose intolerance can be relieved  
    • Antibacterial activity: B. coagulans produces antibacterial substances that inhibit the growth of pathogenic intestinal bacteria and instead allow beneficial bacteria to grow better in our intestines  
    • Immune system regulation: B. coagulans can normalize the activity of the immune system and thus have a positive effect on the immune system  

     

    More specific health benefits found in studies  

    • Cholesterol reduction: B. coagulans lowers blood cholesterol and has reduced weight gain on a fatty diet in mice.  
    • Inhibition of inflammation: By regulating the immune system, adding B. coagulans to mice protected against inflammation and oxidative damage in the intestine. The probiotic also showed a positive effect on the immune system in immunosuppressed mice, as can happen after chemotherapy.  
    • Rheumatism patients: This, together with the anti-inflammatory properties of the bacterium, indicated in a study that pain and symptom improvement in rheumatism patients whose joints are inflamed.  
    • Irritable Bowel Syndrome (IBS): Since B. coagulans has a good regulating effect on our intestinal microbiome, with which many diseases are associated, taking this probiotic in patients with the chronic intestinal inflammation “Irritable Bowel Syndrome” (IBS), which causes pain and Significantly reduced flatulence and improved quality of life by reducing other symptoms of the disease. A possible trigger for intestinal-related diseases can sometimes be the more frequent use of antibiotics, as this can disrupt our microbiome.  
    • Antibiotic-associated problems: B. coagulans prevented microbiome disruption and antibiotic-associated diarrhea in 71% of children, while in the experimental group it was only 38%.  
    • Skin health: In addition, an improvement in skin appearance and skin aging was discovered in mice when B. coagulans was consumed.

     

     

    Comparison with other probiotics  

    Bacillus coagulans differs from other probiotics such as Lactobacillus or Bifidobacterium in its ability to form spores. These spores are extremely heat and acid resistant, allowing Bacillus coagulans to survive passage through the acidic stomach and reach the intestines in active form. In comparison, many other probiotics are more sensitive to stomach acid and require special coating techniques to effectively enter the intestines.  

    Recommended dosages and instructions for use  

    The optimal dosage of Bacillus coagulans may vary based on individual health status and desired effect. Generally, dosages in dietary supplements are between 1 and 2 billion colony forming units (CFU) per day. For specific uses, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber supports the effects of Bacillus coagulans , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the intestine. Foods such as whole grains, vegetables and fruit are recommended. In addition, care should be taken to ensure adequate fluid intake.  

    Which AgilNature® products contain Bacillus coagulans? 

    Product 

    Crowd 

    NRV* 

    ProtectAgil  

    2 x 10 9 CFU***  

    ** 

     

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = colony forming units  

     

    Literature: 

    1. Lee NK, Kim WS, Paik HD. Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier. Food Sci Biotechnol. 2019 Oct 8;28(5):1297-1305.  
    2. Jiang Cao, Zhiming Yu, Wenyin Liu, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen, Probiotic characteristics of Bacillus coagulans and associated implications for human health and diseases, Journal of Functional Foods, Volume 64, 2020, 103643, ISSN 1756- 4646.  
    3. Aminlari, L., Shekarforoush, SS, Hosseinzadeh, S. et al. Effect of Probiotics Bacillus coagulans and Lactobacillus plantarum on Lipid Profile and Feces Bacteria of Rats Fed Cholesterol-Enriched Diet. Probiotics & Antimicro. Prot. 11, 1163–1171 (2019).  
    4. Hun L. Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS. Postgrad Med. 2009 Mar;121(2):119-24.  
    5. La Rosa M, Bottaro G, Gulino N, et al. [Prevention of antibiotic-associated diarrhea with Lactobacillus sporogens and fructo-oligosaccharides in children. A multicentric double-blind vs placebo study] Minerva Pediatrica. 2003 Oct;55(5):447-452.  
    6. Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]. Medicine (Baltimore). 2021 Jan 22;100(3):e23641.  
    7. Wang Y, Lin J, Cheng Z, Wang T, Chen J, Long M. Bacillus coagulans TL3 Inhibits LPS-Induced Caecum Damage in Rat by Regulating the TLR4/MyD88/NF-κB and Nrf2 Signal Pathways and Modulating Intestinal Microflora. Oxide Med Cell Longev. 2022 Feb 7;2022:5463290.  
    8. Zhao Z, Sun M, Cui X, Chen J, Liu C, Zhang Sci Rep. 2023 Jul 10;13(1):11181.  
    9. Mandel DR, Eichas K, Holmes J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010 Jan 12;10:1.  
    10. Hiramoto K, Kubo S, Tsuji K, Sugiyama D, Iizuka Y, Hamano H. The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging. Dermatopathology (Basel). 2023 Sep 28;10(4):287-302.  
  • Agil Nature

    Biotin (Vitamin B7 / Vitamin H)

    Biotin is a water-soluble vitamin that belongs to the vitamin B group. It is also known as vitamin B7 or vitamin H. As a coenzyme, it is involved in numerous metabolic processes in the body. This means that many enzymes that carry out various metabolic steps rely on biotin and cannot function without it. Our body cannot produce this vitamin itself and therefore it must be obtained through food.  

     

    Biotin as a coenzyme

    Biotin is used in many ways as a coenzyme and is involved in reactions within energy metabolism, fatty acid synthesis, cholesterol synthesis, gluconeogenesis and the breakdown of odd-numbered fatty acids and the amino acids leucine, isoleucine, valine, methionine and threonine. During enzyme reactions, a chemical group is transferred to other groups and biotin serves as an “intermediate holder” to enable these transfers. Thus, biotin enables the formation of fatty acids in our body, the production of sugar in our body and the production of energy from it. Without biotin, our body lacks energy.  

    Additionally, biotin is involved in the regulation of gene expression, cell division and repair of DNA damage. This also results in biotin's role in the growth of blood and nerve cells, sebaceous glands as well as skin, hair and nails.  

    Biotin is therefore essential for essential functions in our body and the importance is also shown in the observation of a study in which it was found that even with severe biotin withdrawal, our body downregulates the uptake and function in the liver and kidneys in order to ensure the availability for to ensure the brain.  

     

    Biotin – the most important tasks in brief  

    The following vitamin B6-related health claims have been evaluated and approved by the European Food Safety Authority (EFSA) through scientific studies:  

    • Biotin contributes to a normal energy-rich metabolism. 
    • Biotin contributes to the normal functioning of the nervous system. 
    • Biotin contributes to normal macronutrient metabolism. 
    • Biotin contributes to normal psychological function. 
    • Biotin contributes to the maintenance of normal hair. 
    • Biotin contributes to the maintenance of normal mucous membranes. 
    • Biotin helps maintain normal skin. 

    Your daily need for biotin 

    The German Nutrition Society recommends an intake of 40 µg per day for young people over 15 and adults. Breastfeeding women have an increased requirement of 45 µg per day.  

     

    Biotin is found naturally in numerous foods, such as: liver and kidneys, nuts and sunflower seeds, (boiled) eggs, especially egg yolks, soybeans, oatmeal and mushrooms. Likewise milk & dairy products and multi-fruit juices.  

     

    Diet-related biotin deficiency rarely occurs. Exceptions are if you have a very unbalanced diet with a high consumption of raw egg whites. Raw egg whites contain avidin, which binds biotin and thus prevents it from being absorbed into the body. Avidin is inactivated during cooking and therefore this problem is not found in boiled eggs.  

    Reasons for impaired biotin absorption or promoted biotin degradation include high alcohol consumption, smoking and taking anticonvulsants (medications to prevent epileptic seizures).  

    A biotin deficiency can also occur in a metabolic disease in which the enzyme biotinidase is missing. Biotin is not directly available to us after eating, but is bound to proteins and the vitamin must first be split off from them using the enzyme biotinidase. However, the absence of the enzyme is usually checked during newborn screening in order to enable early treatment and prevent subsequent damage and a possible fatal outcome.  

     

    A high-dose intake of 20 mg of biotin per day has not yet shown any negative effects on people.  

     

    How a biotin deficiency can manifest itself  

    The deficiency symptoms of biotin are numerous and start with symptoms such as thinning hair with progressive loss of all hair on the body, scaly, red rash around body openings (eyes, mouth, nose, perineum), conjunctivitis, brittle nails, skin infections, general feeling of weakness, up to In advanced stages, they manifest themselves in seizures, depression, hallucinosis, abnormal sensations and developmental delay in infants. Without enough biotin, the brain's behavior changes and you feel confused and out of control. So you have many neurological disorders that can develop.  

     

    The congenital metabolic disease in which biotinidase is missing can result in hearing and vision disorders, developmental disorders, skin changes, hair loss (alopecia), cramps, low blood pressure and ketoacidosis (hyperacidity) if not treated, as well as fatal outcomes due to the symptoms.  

     

     

    Which AgilNature products contain vitamin B2? 

    Product 

    Crowd 

    NRV* 

    ProtectAgil 

    22.5 μg per daily ration (3 capsules each) 

    45% 

    DermAgil Beauty 

    80 µg per daily ration (1 capsule each) 

    160% 

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

     

    Literature: 

    1. Biotin. DGE. https://www.dge.de/gesunde-ernaehrung/faq/biotin/#c5041 (accessed on December 15, 2023) 
    2. León-Del-Río A. Biotin in metabolism, gene expression, and human disease. J Inherit Metab Dis. 2019 Jul;42(4):647-654. 
    3. Health insurance fund, A.-. D. (2023, May 24). Biotin: The vitamin for beauty? AOK - The Gesundheitskasse. https://www.aok.de/pk/magazin/ernaehrung/vitamine/biotin-das-vitamin-fuer-die-schoenheit/ 
    4. Regulation (EC) No. 1924/2006 (Health Claims) 
  • Agil Nature

    Broccoli

    Broccoli (Brassica oleracea was. italica) belongs to the cruciferous family (Brassicaceae), like all other types of cabbage. But (horse)radish, radishes, cress, rocket or mustard are also included (1). Originally, all types of cabbage come from the wild type Brassica oleracea was. oleracea whose origin is the Mediterranean and the west coasts of Europe. Only since the 20th In the 19th century, broccoli grew in importance. Today it can be grown in most countries around the world, including Germany. Broccoli is valued above all for its ingredients. It is rich in minerals such as potassium, calcium, phosphorus and iron, but also in vitamins (provitamin A, vitamin C, B vitamins and folic acid) (2). Probably the most important ingredients are the glucosinolates (mustard oil glycosides). you or their breakdown products, the isothiocyanates (mustard oils), are said to have antioxidant and even anti-cancer properties. The mustard oil found in broccoli is sulforaphane (1, 2, 3).

     

     

    Glucosinolatess, Isothiocyanate und Sulforaphan

    Glucosinolate, also called mustard oil glycosides, such as the phenolic compounds of Olive, to the phytochemicals and are found in all cruciferous vegetables (1, 3).

    Isothiocyanate, also called mustard oils, are the active breakdown products of glucosinolates. They usually only occur when the vegetables are processed. As soon as a plant cell is damaged, e.g. by cutting or biting, the enzyme myrosinase is released, which splits the glucosinolate into a mustard oil. Myrosinase is not only contained in cruciferous vegetables themselves, but also in our intestinal flora. Among other things, mustard oils are responsible for the pungent, sometimes bitter taste and typical smell of cruciferous vegetables (1).

    Sulforaphan is the mustard oil found in broccoli. It is formed with the help of myrosinase from the glucosinolate glucoraphanin. Sulforaphane is said to have antioxidant, anti-inflammatory, and antitumor properties (1). This is said to be mainly due to the activation of phase II enzymes and antioxidant factors (4)

     

     

    How Phase II Enzymes Contribute to Detox

    With food, the body is also supplied with many substances that are not needed or can even be toxic. So that these mostly fat-soluble foreign substances do not accumulate in the body, there is a very specific process, the foreign substance metabolism (also known as biotransformation). Here, the substances are made sufficiently water-soluble so that they can then be excreted via the kidneys and bile. This process is divided into 3 phases: phase I - modification, phase II - conjugation and phase III - elimination. In the first step, the foreign substance is modified (phase I enzymes). This is how some drugs unfold their effect, but the substance can also become more reactive or even more toxic. Nevertheless, this step is necessary so that the foreign substance can be made water-soluble by the phase II enzymes in the next step. The substance can then be eliminated, i.e. excreted (3). By activating the phase II enzymes, sulforaphane can promote the faster elimination of foreign substances in the body, i.e. detoxification. Detox), from which the antioxidant, anti-inflammatory and cell-protecting effects can be derived (4, 5).

     

    Supporting detoxification with BroccoRaphanin®

    Many studies have already shown that sulforaphane supports the detoxification process in the body and thus has anti-tumour, antioxidant and anti-inflammatory effects. That's why we use BroccoRaphanin®, a unique extract from broccoli seeds, for our DetoxAgil dietary supplement. With BroccoRaphanin® we can optimally support the body's own detoxification, as it contains a naturally high content of at least 10% glucoraphanin, the precursor of sulforaphane. Thanks to the patented, gentle manufacturing process, these valuable ingredients are also particularly well protected (6).

     

     

    Which AgilNature products contain BroccoRaphanin®?

    Product

    milligram

    * NRV

    DetoxAgil

    300 mg per capsule

    **

     

     
    *Nutrient Reference Value* Percentage of the reference value according to Annex XIII of the Food Information Regulation (EG) No. 1169/2011.
    ** No recommendation available.

     

     Literature:

    1. Herr, Ingrid (2014): The Cruciferous Vegetables on the Crusade Against Cancer. In: Passion Surgery (June, 4 (06)).

    2. Federal Office for Agriculture and Food (ed.) (2020): Cauliflower, Broccoli. Product information.

    3. Biesalski, Hans Konrad; Bischoff, Stephan C.; Pirlich, Matthias; Weimann, Arved (ed.) (2018): Nutritional Medicine. Based on the curriculum for nutritional medicine of the German Medical Association. With the collaboration of Michael Adolph, Jann Arends, Ulrike Arens-Azevêdo and Christine von Arnim. 5th, completely revised and expanded edition. Stuttgart: Georg Thieme Verlag.

    4. Hensel, Andreas; Lechtenberg, Matthias (2020): Broccoli-based dietary supplements – what is the quality situation like? In: Journal of Phytotherapy 41 (03), pp. 113-122.

    5. Juge, N.; Mithen, R. F.; Traka, M. (2007): Molecular basis for chemoprevention by sulforaphane: a comprehensive review. In: Cellular and Molecular Life Sciences 64 (9), S. 1105–1127. DOI: 10.1007 / s00018-007-6484-5.

    6. IFF Health (2022): Innovative Broccoli Raffinate. In: IFF Health. https://iff-health.com/portfolio/brocco-raphanin/ (accessed 2022-02-04)

  • Agil Nature

    Bamboo

    Origin and history of bamboo

     

    Bamboo is a type of grass and is arguably the fastest growing plant in the world. A growth of 10cm per day is common, some species even grow up to 5cm per hour. The miracle tube not only grows quickly, it is also extremely stretchy and extremely stable and at the same time light as a feather. Thanks to its high flexural strength, it has been popular as a building material in China for thousands of years. In China there are bamboo bridges that have been spanning rivers for 1000 years. Bamboo houses are even considered earthquake-proof due to their high flexibility and elasticity.

    People also use the strengthening properties of bamboo for their health. A thousand years ago, monks used bamboo (Bambusa arundinacea) to produce a silicon-rich substance called tabashir, which is still used today as a traditional remedy in Eastern medicine.

     

     

    Bamboo - natural silicon for bone structure

     
     
     
    Bambus Vitalstoff Lexikon AgilNature
     
     

    Silicon is an important trace element, of which the human body contains about 1 to 2g.(1) In nature, silicon is never found in its pure form, but always in combination with oxygen as silicon dioxide. In combination with water it is called silicic acid. Bamboo is one of the best sources of natural silicon dioxide. Is is a real silicon accumulator,

     

    because it needs silicon for its extreme strength and flexibility. Our body loses around 10-40mg of silicon every day through excretions, sloughing of the skin and cutting hair and nails. With age, the body's ability to absorb silicon decreases. (1) Therefore, the silicon content in the tissues decreases with increasing age. Appropriate nutritional supplementation can help to normalize silicon levels in the tissues again. (2)

    Silicon is important for bone formation, it is characterized by a strengthening function. Primarily, silicon appears to promote the synthesis and stabilization of collagen. If there is a silicon deficiency, less collagen is formed in the bones (3). Collagen is the basic building material for bones and is important for bone formation. Just as steel girders support a building, collagen fibers form the supporting framework in bone. If a house lacks steel beams, it would crumble under even a small load. It's the same with bones: without collagen, they lose elasticity and become brittle.

     

     

    Your daily need for silicon

    So far there is no official recommendation for the daily silicon requirement. As a dietary supplement, an intake of 10-20 mg silicon per day is recommended. The natural silicon from bamboo is particularly well tolerated and can be easily absorbed by the body.

     

     

    Study Findings: High dietary silicon intake improves bone health

    Research over the last 30 years confirms that the intake of silicon has positive effects on bone health (1). For example, an epidemiological study with 2847 participants showed that increased silicon intake can increase bone density in men and younger women. (4) Silicon also showed positive effects on bone health in postmenopausal women who were dependent on hormone replacement therapy (5)

    Increased bone density plays a central role in bone formation and the prevention of osteoporosis.

     

    Which AgilNature® products contain bamboo?

    Product
    DetoxAgil Tee

     

     

    Literature:

    1. Holzer G, Holzer LA (2011): Silicon and its importance for bone metabolism. Swiss Journal of Nutritional Medicine 1/11: 34-37.
    2. Holzer G, Holzer LA (2008): Silicon in the therapy of osteoporosis. J Miner Metabolism. 2008; 15(2)
    3. Seaborn CD, Nielsen FH. (2002): Silicon deprivation decreases collagen formation in wounds and bone, and ornithine transaminase enzyme activity in liver. Biol Trace Elem Res. 2002 Dec; 89(3):251-61
    4. Jugdaohsingh R et al. (2004): Dietary silicon intake is positively associated with bone mineral density in men and premenopausal women of the Framingham Offspring cohort. J Bone Miner Res. 2004 Feb; 19(2):297-307
    5. Jugdaohsingh R. (2007):Silicon and bone health. J Nutr Health Aging. 2007; 11(2): 99–110.

     

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