5 articles Found
  • Lactobacillus rhamnosus
    Agil Nature

    Lactobacillus rhamnosus

    Overview :  

    Lactobacillus rhamnosus , formerly a subspecies of Lactobacillus casei considered , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Since the bacterium's discovery, it has been the most studied probiotic bacterium in the world, with a large number of studies.  

    Lactobacillus rhamnosus finds Its main use is as a probiotic . Probiotics are living microorganisms that, in certain quantities, provide health benefits. for example by influencing the intestinal microbiome . It is worth mentioning that the current scientific view is that Lactobacillus rhamnosus is only a temporary resident in our intestines and after taking it as a probiotic does not remain permanently in the intestines once you stop taking it.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health: L. rhamnosus In studies, it repaired an already damaged protective barrier in the colon and also stimulated the production of mucin , a building block of this barrier . In mice, this resulted in an improvement in intestinal disorders such as constipation . In addition, it regulates the intestinal flora by promoting the proliferation of beneficial bacteria and inhibiting the growth of harmful bacteria .  

    • Immune system regulation: L. rhamnosus In studies, it has been shown to stimulate the natural immune system and ensure balance. Thanks to its stimulating effect In studies on hamsters and mice, it showed a positive influence on diseases such as inflammatory reactions in rheumatoid arthritis, osteoporosis and chronic inflammation of the colon ( colitis )  

    • Respiratory diseases: Based on studies it is suspected that L . rhamnsosus may play a mild prophylactic role in the prevention and treatment of some respiratory diseases. Since underweight children are associated with a high risk of various infections, L . rhamnosus investigated in this context. Here, too, L . rhamnosus the risk of infection and the resulting respiratory diseases.  

    • Lowering blood pressure: In combination with Bifidobacterium lactis In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , L . rhamnosus therefore has a positive effect on blood pressure when taken over a longer period.  

    • Help with diarrhea: Several studies, both in children and adults, indicate an improvement in the duration and symptoms of diarrhea for various causes. Children infected with rotavirus had an improvement in the symptoms of diarrhea caused by L. rhamnosus had a lower risk of suffering from diarrhea symptoms lasting more than one week. Diarrhea is a major problem, especially during antibiotic treatment, but the risk has been reduced in adults with L . rhamnosus as a probiotic. Scientists therefore believe that the frequency, duration, and severity of diarrhea caused by L. rhamnosus can be reduced. The European Food Safety Authority confirms this after testing However, this was not the case in 2013 , so it cannot be said with certainty but is a guess .  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Positive influence on the gut-brain axis : It has recently been discovered that gut health influences the brain, as both influence each other through the gut-brain axis. In mice, L. rhamnosus positive influence on these by alleviating noise-induced cognitive deficits and because when taken at a young age, the offspring showed less anxious behavior .  

    • Insulin resistance: In a study on mice, L . rhamnsosus to regulate blood sugar by reducing insulin resistance. Additionally, they also showed lower weight gain compared to control mice.  

    • Lactose intolerance: A study showed that L . rhamnosus together with Bifidobacterium longum and vitamin B6, alleviated symptoms associated with lactose intolerance. These probiotics led to fewer constipation and bloating symptoms in the subjects.  

    • Liver-protective: Together with inosine , L. rhamnosus ameliorated alcohol-induced liver damage in mice .  

    • Atherosclerosis: By influencing fatty acid and ketone body metabolism , L. rhamnosus slowed the progression of atherosclerosis in an animal study.  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus rhamnosus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day. For specific applications, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.   

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNature , we 've also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics like Lactobacillus rhamnosus , for maximum effect. Our product SynbioticAgil also contains the prebiotic inulin.  

    Dangers of taking  

    The consumption of Lactobacillus rhamnosus strains, marketed as probiotics, is considered safe. However, in rare cases, it can lead to sepsis in certain at-risk groups. People with weak immune systems and infants are considered at risk and should therefore avoid taking them.  

     

    Which AgilNature ® products contain Lactobacillus rhamnosus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    6 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. GW Tannock, K. Munro et al.: Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. In: Applied and environmental microbiology. Volume 66, Number 6, June 2000, pp. 2578–2588, ISSN 0099-2240. 

    1. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017; 6(4):21. 

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Guandalini , Stefano; Pensabene, Licia; Zikri, Mona Abu*; Dias, Jorge Amil†; Casali, Luigi Gobio‡; Hoekstra, Hans§; Kolacek, Sanja÷; Massar, Karin§; Micetic –Turk, Dusanka; Papadopoulou, Alexandra#; de Sousa, Jaime Salazar**; Sandhu, Bhupinder††; Szajewska , Hanna‡‡; Weizman, Zvi§§. Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial. Journal of Pediatric Gastroenterology and Nutrition 30(1 ):p 54-60, January 2000. 

    1. Österlund, P., Ruotsalainen, T., Korpela, R. et al. Lactobacillus supplementation for diarrhea related to chemotherapy of colorectal cancer: a randomized study. Br J Cancer 97, 1028–1034 (2007). 

    1. Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persistent Functional Gastrointestinal Symptoms: A Randomized , Double-Blind, Cross-Over Study. Nutrients. 2019 Apr 19;11(4):886. 

    1. Arellano-García L, Macarulla MT, Cuevas-Sierra A, Martínez JA, Portillo MP, Milton- Laskibar I. Lactobacillus rhamnosus GG administration partially prevents diet-induced insulin resistance in rats: a comparison with its heat-inactivated parabiotic. Food Function . 2023 Oct 2;14(19):8865-8875. 

    1. Sapra L, Saini C, Das S, Mishra PK, Singh A, Mridha AR, Yadav PK, Srivastava RK. Lactobacillus rhamnosus (LR) ameliorates pulmonary and extrapulmonary acute respiratory distress syndrome (ARDS) via targeting neutrophils. Clin Immunol. 2024 Jan;258:109872 . 

    1. Kumpu , M., Kekkonen, R., Kautiainen , H. et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 66, 1020–1023 (2012). 

    1. Kara SS, Volkan B, Erten I. Lactobacillus rhamnosus GG can protect malnourished children. Benef Microbes. 2019 Apr 19;10(3):237-244. 

    1. Guo M , Liu H, Yu Y , Zhu Good Microbes. 2023 Jan-Dec;15(1):2190304 . 

    1. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023 Jul;228(4):152415. 

    1. Tong L, Zhang X, Hao H , Liu Q, Zhou Z, Liang Nutrients. 2021 Sep 23;13(10):3319 . 

    1. Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr . 2000 Feb;83(2):167-76. 

    1. Chen L, Li S, Peng C, Gui Q, Li J, Xu Z, Yang Y. Lactobacillus rhamnosus GG Promotes Recovery of the Colon Barrier in Septic Mice through Accelerating ISCs Regeneration. Nutrients. 2023 Jan 28;15(3):672. 

    1.  Gu Y, Qin X, Zhou G, Wang C, Mu C, Liu X, Zhong W , Xu Food Function . 2022 Nov 28;13(23):12144-12155. 

    1. Li X , Zheng P , Cao W, Cao Y, She X, Yang H, Ma K, Wu F , Gao Front Cell Infect Microbiol . 2023 Apr 26;13:1067367 . 

    1. Zhou B, Jin G, Pang X, Mo Q, Bao J, Liu T, Wu J, Xie R, Liu X, Liu J, Yang H , Xu Pharmacol Res. 2022 Mar;177:106090 . 

    1. Zhai T, Ren W, Wang P, Zheng L. Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis. Appl Microbiol Biotechnol . 2022 Dec;106(24):8233-8243 . 

    1. Zhu Y , Wang​ Toxicol Appl Pharmacol . 2022 Mar 15;439:115923 . 

    1. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło -Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. 

    1. Boggio Marzet C, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr . 2022 Feb;120(1 ):e 1-e7. English, Spanish. 

    1. Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for physicians. J Microbiol Immunol Infect. 2021 Aug;54(4):575-580. 

    1. Zhang B, Lynch B, Zhao J, Guo Y, Mak A. Lactobacillus rhamnosus MP108: Toxicological evaluation. J Food Sci. 2021 Jan;86(1):228-241. 

  • Lactobacillus paracasei
    Agil Nature

    Lactobacillus paracasei

    Overview :  

    Lactobacillus paracasei , is a gram-positive lactic acid bacterium of the family Lact obacillac eae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus paracasei finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines . As a probiotic, L. paracasei especially found in fermented vegetables or dairy products such as kefir. L. paracasei survives the gastrointestinal tract well and can survive there for up to 3 days.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Supports dental health: Streptococcus mutans is the primary bacterium responsible for caries formation. L. paracasei demonstrated inhibitory activity against this bacterium by attaching to it and causing it to clump together. This prevents S. mutans from adhering to the tooth and allows it to be washed away with saliva or when brushing.  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. paracasei promotes a It promotes a healthier balance in the intestines and increases the diversity of the intestinal flora. Likewise, the concentration of healthy, short-chain fatty acids in the intestines increases. Therefore, L. paracasei may be helpful in motility disorders of the gastrointestinal tract.  

    • Inhibits pathogens : L. paracasei inhibits the growth of certain pathogens such as E. coli , which is often associated with diarrhea .  

    • Weight control: Through its positive impact on intestinal health , L. paracsaei also positively influences weight. L. paracasei exhibits anti-obesity properties, alleviating obesity in mice by influencing fatty acid metabolism. In the study, 10 weeks of supplementation with the probiotic showed similar results to treatment with drugs such as orlistat .  

    • Immune system regulation: It is believed that L. paracasei can have a positive effect on the immune system and could have a supportive or preventative effect in diseases . For example, against viral infections, where an infection with the influenza virus could be better managed in mice . The potential of L. paracasei to improve resistance to common cold infections was also shown in test subjects . It is also used in allergy-related inflammation of the nasal mucosa . L. paracasei a positive influence is suspected.  

    • Cardiometabolic benefits: Supplementation with L. paracasei demonstrated positive effects on several cardiometabolic risk factors, including a reduction in cholesterol levels, which was associated with improved endothelial function by up to 5% in subjects. Furthermore, 12 weeks of supplementation also showed an improvement in metabolic syndrome (symptoms such as obesity, hypertension , and impaired glucose and lipid metabolism) , as both a reduced severity and a lower frequency of the syndrome were observed in subjects.  

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium longum half L. paracasei Subjects after 8 weeks of use , to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life by Relief of gastrointestinal symptoms and improvement of psychological well -being .  

    • Bone health : Ovariectomy (OOP) and postmenopause are associated with osteoporosis, which is a loss of bone density and increases the risk of bone fractures. Studies have shown that L. paracasei reduces bone loss in oophorectomy by reducing inflammation, thus offering hope as a treatment or preventative method for postmenopausal osteoporosis.  

    • Hyperuricemia: Hyperuricemia, which is an elevated level of uric acid in the blood that can lead to gout, causes an imbalance in the intestinal flora by increasing pathogenic bacteria and decreasing diversity. L. paracasei was shown to repair precisely this imbalance in experiments, reversing organ damage and alleviating inflammatory symptoms in hyperuricemia mice .  

    The optimal dosage of Lactobacillus paracasei can vary depending on individual health status and desired effect. Generally, dosages in supplements range from 1 to 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus paracasei , to ensure the best possible effect. Our product, SynbioticAgil, contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus paracasei is considered safe , even for the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus paracasei ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    7.17 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Chen JF, Hsia KC, Kuo YW, Chen SH, Huang YY, Li CM, Hsu YC, Tsai SY, Ho HH. Safety Assessment and Probiotic Potential Comparison of Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus plantarum LPL28, Lactobacillus acidophilus TYCA06, and Lactobacillus paracasei ET-66. Nutrients. 2023 Dec 29;16(1):126 . 

    1. Radicioni M, Koirala R, Fiore W, Leuratti C, Guglielmetti S, Arioli S. Survival of L. casei DG® (Lactobacillus paracasei CNCMI1572) in the gastrointestinal tract of a healthy pediatric population. Eur J Nutr . 2019 Dec;58(8):3161-3170. 

    1. Dehghani Champiri I, Bamzadeh Z, Rahimi E, Rouhi L. Lacticaseibacillus paracasei LB12, a Potential Probiotic Isolated from Traditional Iranian Fermented Milk ( Doogh ). Curr Microbiol . 2023 Sep 2;80(10):333. 

    1. Zhao Z, Wu J, Sun Z, Fan J, Liu F, Zhao W, Liu WH, Zhang M, Hung WL. Postbiotics Derived from L. paracasei ET-22 Inhibit the Formation of S. mutans Biofilms and Bioactive Substances : An Analysis. Molecules . 2023 Jan 27;28(3):1236 . 

    1. A Caridi, Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei , Journal of Industrial Microbiology and Biotechnology, Volume 29, Issue 6, 1 December 2002, Pages 303–308. 

    1. Cao J, Liu Q, Hao H, Bu Y, Tian X, Wang T, Yi H. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice. Front Immunol. 2022 Jul 6;13:940228 . 

    1. Cheng S, Li H, Ding Y, Huo J, Zheng Y, Jiang Y, Zhang Y, Man C. The Probiotic Combination of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 Alleviates Gastrointestinal Motility Disorder via Improving Gut Microbiota. Nutrients. 2023 Feb 7;15(4):839 . 

    1. Shin YJ, Bae JM, Cho HR, Mahoro P, Kim HH, Kim SH, Kim TH, Bae MJ. Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei , L. casei 431 on High-Fat Diet-Induced Obese Rats. J Med Food. 2023 Jul;26(7):445-453 . 

    1. Yang J, Huang J, Huang Z, Xu Y, Li W, Zhu S, Zhao Y, Ye B, Liu L, Zhu J, Xia M, Liu Y. Cardiometabolic benefits of Lacticaseibacillus paracasei 8700:2: A randomized double-blind placebo-controlled trial. Clin Nutr . 2023 Sep;42(9):1637-1646. 

    1. Kim S, Lee S, Kim TY, Lee SH, Seo SU, Kweon MN. Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection. Microbiomes. 2023 Nov 23;11(1):260. 

    1. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel- Higounenc I, Guéniche A. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defenses . Benef Microbes. 2014 Jun 1;5(2):129-36 . 

    1. Güvenç IA, Muluk NB, Mutlu FŞ, et al. Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis . American Journal of Rhinology & Allergy. 2016;30(5 ):e 157-e175. 

    1. Murata M, Kondo J, Iwabuchi N, Takahashi S, Yamauchi K, Abe F, Miura K. Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. Benef Microbes. 2018 Dec 7;9(6):855-864 . 

    1. Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl SH, Farman HH, Movérare-Skrtic S, Islander U, Sjögren K. Probiotics protect mice from ovariectomy-induced cortical bone loss . PLoS One . 2014 Mar 17;9(3 ):e 92368. 

    1. Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized , Placebo- Controlled Study. Nutrients . 2020 Apr 21;12(4):1159. 

  • Lactobacillus acidophilus
    Agil Nature

    Lactobacillus acidophilus

    Overview :  

    Lactobacillus acidophilus , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus acidophilus finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines, where it can break down bile acids. L. acidophilus is used as a probiotic. especially used in sour milk products , for example in yoghurts . Since L. acidophilus Because it prefers to live and be active at low pH levels , it survives the acids of the gastrointestinal tract well.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. acidophilus produces antibacterial peptides that are effective against potentially pathogenic bacteria such as Escherichia coli. Staphylococcus aureus and Salmonella enteritidis . In addition , L. acidophilus pH , which can also inhibit the growth of many pathogens in the gut, as some prefer a more neutral or alkaline environment. This promotes a healthy balance in the gut.  

    • Lowers cholesterol: In some experiments, L. acidophilus has shown cholesterol-lowering effects and an inhibitory effect on atherosclerosis , which can lead to heart attacks due to cholesterol deposits in the blood vessels. Therefore, a supply of L. acidophilus could reduce the risk of cardiovascular disease.  

    • Intestinal inflammation: Colitis is a chronic inflammation of the intestine that can be triggered by a disrupted intestinal barrier, an imbalanced intestinal flora, and genetic susceptibility. The main treatment for such intestinal inflammations is probiotics, and L. acidophilus has also proven helpful here. Thanks to the immunomodulatory properties of L. acidophilus , it reduces inflammatory reactions in the body. The protective function of the intestine has also been strengthened in studies with L. acidophilus .  

    • Help with diarrhea: In combination with other antibiotics , especially other Lactobacillus species and Bifidobacterium species , L. acidophilus the risk of diarrhea in young children from 32% to 20%.  

    • Weight control: By positively influencing intestinal imbalance and other factors, L. acidophilus Supplementation also improved weight loss in mice with obesity and associated diseases . Improvements in energy, sugar, and lipid metabolism were also observed in this regard .  

    • Immune system regulation: L. acidophilus shows positive effects on the immune response by influencing inflammatory processes and immune response in some pathogens such as the fungal infection Candida albicans .  

    • Cholesterol-lowering : Some laboratory and animal studies show significant reduction of serum cholesterol by L. acidophilus Addition . However, the experiments show differences among themselves, so the specific cholesterol-lowering effect is not yet fully understood from a scientific perspective.  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium animalis ssp . lactis helped L. acidophilus Subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, particularly through shorter and milder pain symptoms , as well as other symptom relief.  

    • Lactose intolerance: L. acidophilus Studies have shown improved lactose digestion and relieved symptoms such as bloating and diarrhea.  

    • Osteoporosis : Age , as well as postmenopause in women , can lead to this bone disease, which causes brittle bones due to porous bones . Its immunomodulatory effect was shown in a mouse study L. acidophilus administration may improve bone architecture and increase mineral density . By influencing the balance of certain immune cells, L. acidophilus as a probiotic, have an osteo-protective effect, especially for women with postmenopausal osteoporosis.  

    • Rheumatism: In rheumatoid Arthritis, or rheumatism for short, is an inflammatory joint disease associated with pain and stiffness. The inflammatory reactions can also have harmful effects on other organs. While the exact mechanisms are still unclear, experiments suggest that long-term use of L. acidophilus may help with arthritis by counteracting the inflammatory reactions in the body and thus protecting against more serious damage.  

    • Dermatitis: Due to the anti-inflammatory response that L. acidophilus could promote in the body , the probiotic improved the progression of dermatitis, a skin inflammatory disease, in a mouse model.  

    • ADHD: In a 3-month study in ADHD subjects aged 6-16, additional supplementation with L. acidophilus When taking the drug Amotextin , improvements in therapy such as in the concentration of children are observed .  

    • Liver cancer : Through the production of valeric acid by L. acidophilus , a suppression of the growth of liver cancer cells was observed in mice .  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus acidophilus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus acidophilus , to ensure the best possible effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus acidophilus is considered safe for health , even in the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus acidophilus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    4.41 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. SE Gilliland, ML Speck: Deconjugation of bile acids by intestinal lactobacilli. In: Applied and Environmental Microbiology. Volume 33, No. 1, 1977, ISSN 0099-2240, pp. 15-18, 

    1. Gao H, Li X, Chen X, Hai D, Wei C, Zhang L, Li P. The functional roles of Lactobacillus acidophilus in different physiological and pathological processes. J Microbiol Biotechnol . 2022 Oct 28;32(10):1226-1233. 

    1. Xing TL, Bian X, Ma CM, Yang Y, Liu Food Function . 2023 Mar 6;14(5):2472-2480. 

    1. Li P, Chen G, Zhang J, Pei C, Chen Y, Gong J, Deng S, Cai K, Li H, Wang D, Shen B, Xie Z, Liao Q. Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis. Food Function . 2022 Mar 7;13(5):2985-2997 . 

    1. Kye YJ, Lee SY, Kim HR, Lee BH, Park JH, Park MS, Ji GE, Sung MK. Lactobacillus acidophilus PIN7 paraprobiotic supplementation ameliorates DSS-induced colitis through anti-inflammatory and immune regulatory effects. J Appl Microbiol . 2022 Apr;132(4):3189-3200 . 

    1. Lukasik J, Dierikx T, Besseling -van der Vaart I, de Meij T, Szajewska H; Multispecies Probiotic in AAD Study Group. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatrics . 2022 Sep 1;176(9):860-866. 

    1. Skrzydło-Radomańska B, Prozorow -Król B, Cichoż -Lach H, Majsiak E, Bierła JB, Kosikowski W, Szczerbiński M, Gantzel J, Cukrowska B. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020 Jul 5;12(7):1999. 

    1. Li P, He Probiotics Antimicrob Proteins. 2023 Dec 5 . 

    1. Kang Y, Kang X , Yang H, Liu H, Yang X, Liu Q, Tian H, Xue Y, Ren P, Kuang Pharmacol Res. 2022 Jan;175:106020 . 

    1. Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, Choi JW, Park JS, Jhun J, Park SH, Cho ML. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023 Jun 14;21(1):135. 

    1. Lau HC, Zhang X, Ji F, Lin Y, Liang W, Li Q, Chen D, Fong W, Kang EBioMedicine . 2024 Feb;100:104952 . 

    1. Elhossiny RM, Elshahawy HH, Mohamed HM, Abdelmageed RI. Assessment of probiotic strain Lactobacillus acidophilus LB supplementation as adjunctive management of attention-deficit hyperactivity disorder in children and adolescents: a randomized controlled clinical trial. BMC Psychiatry. 2023 Nov 9;23(1):823 . 

    1. Paul AK, Paul A, Jahan R, Jannat K, Bondhon TA, Hasan A, Nissapatorn V, Pereira ML, Wilairatana P, Rahmatullah M. Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus. Microorganisms. 2021 May 16;9(5):1070 . 

    1. Amdekar S, Singh V, Kumar A, Sharma P, Singh R. Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines. Indian J Clin Biochem . 2014 Oct;29(4):471-8 . 

    1. Bungau SG, Behl T, Singh A, Sehgal A, Singh S, Chigurupati S, Vijayabalan S, Das S, Palanimuthu VR. Targeting Probiotics in Rheumatoid Arthritis. Nutrients. 2021 Sep 26;13(10):3376 . 

    1. Dar HY, Shukla P, Mishra PK, Anupam R, Mondal RK, Tomar GB, Sharma V, Srivastava RK. Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance. Bone Rep. 2018 Feb 5;8:46 -56 . 

    1. Kim WK, Jang YJ, Park S, Min SG, Kwon H, Jo MJ, Ko G. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. JMicrobiol .​ 2024 Feb;62(2):91-99 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

     

  • Bifidobacterium lactis
    Agil Nature

    Bifidobacterium lactis

    Bifidobacterium lactis , also Bifidobacterium animalis ssp . lactis , is a gram-positive lactic acid bacterium of the family Bifidobacteriaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Bifidobacterium animalis ssp . lactis finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . B. lactis is in abundant products used, mainly in dairy products . For example , it is also used in some yogurts in Lidl , listed as " Bifidobacterium BB-12" or in the prominent probiotic Activia yogurts. It is believed that B. lactis the gastrointestinal passage survived well and also has the potential to colonize the intestinal flora over a longer period of time . When taken with inulin, a concomitant dietary fiber, B. lactis was found in stool samples even two weeks after ingestion, indicating successful , long-term colonization in the intestine .  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Provides digestive support: B. lactis Helps digest fiber and plant substances . Since they are not among the bacteria that produce gas during digestion, they can divert fermentation in the large intestine to a non-gaseous end product and thus reduce potential flatulence. In a study on elderly people who consumed 1 x 10 9 CFU/day of B. lactis ( our SynbioticAgil contains 6 times that amount!) , more regular bowel movements were found on 26.9% of days . The number of test subjects who had normal bowel movements on more than 30% of days increased by 114% .  

    • Help with diarrhea: In addition to helping with constipation, A prominent feature of B. lactis is its ability to help with diarrhea. Especially in the elderly , but also in young children and those with antibiotic-associated problems, B. lactis helped to normalize bowel movements. In patients who underwent a 14-day antibiotic therapy and B. lactis income, the strength and risk possible diarrhea symptoms . The risk decreased to 10.8%, compared to the control group, which had a 15.56% risk. The duration also decreased to approximately 2 days instead of 4.  

    • Promotes intestinal health: An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. This imbalance is believed to be related to obesity and weight regulation. B. lactis promotes a healthy balance in the gut and supports its protective function. This keeps bacteria in the gut and reduces the risk of inflammation. According to a study, B. lactis as a probiotic, the intestinal flora of overweight subjects is adapted to the intestinal flora composition that is usually associated with a slimmer phenotype .  

    • Weight control: Through its positive influence on intestinal health , B. lactis also positively influences weight. Supplementation with B. lactis According to studies, it leads to a significant reduction in total body fat mass , food intake , and waist circumference. Fat deposits are particularly reduced in the abdominal area. This is also reflected in the BMI, which was reduced with long-term consumption of B. lactis . Studies assume that fat deposits are reduced due to the positive influence of B. lactis on fatty acid metabolism.  

    • Immune system regulation: It is suspected that B. lactis can help regulate the immune response against pathogens. Laboratory experiments have shown an improvement in the immune response against pathogens such as S. typhimurium , which is often involved in food poisoning due to poor food hygiene. B. lactis has also been shown to be effective against oxidative stress . helpful in rats .  

    • Respiratory symptoms of colds : Studies on toddlers and schoolchildren suggest that B. lactis could help increase the organism's resistance to common infections by strengthening the immune system . According to the studies , B. lactis also reduce the frequency and duration of respiratory infections.  

    • Lowering blood pressure: In combination with Lactobacillus rhamnosus In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , B. lactis may therefore have a positive effect on blood pressure when taken over a longer period of time.  

    • Baby colic: Known as baby colic , or three-month colic , is a period in which babies cry excessively, thought to be caused by abdominal pain , which may be related to the microbiome in the gut. Giving babies B. lactis halved the risk of colic in 80 percent of cases. the length of crying phases. The babies' stools also improved. ( Even though B. lactis is considered beneficial for children and babies, you should consult a doctor before taking it .)  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Type 1 diabetes : According to one study, a six-month supplementation of a mixture of different probiotics, including B. lactis , with concomitant insulin therapy helped improve insulin therapy. Conventional insulin therapy plus probiotics reduced diabetes symptoms by better stabilizing blood sugar levels and lowering HbA1c levels . It's important to note that probiotics are by no means a substitute for insulin therapy, but the right probiotics can potentially enhance it!  

    • Women's health : Together with other probiotics in the mix, B. lactis A positive effect on vascular function and arterial stiffness in overweight postmenopausal women was also shown . In addition, an improvement in bone metabolism was observed in postmenopausal osteoporosis with reduced inflammation.  

    • Coronary heart disease: The simultaneous Taking B.lactis with a conventional therapy regimen ( with atorvastatin and Metoprolol ) is thought to offer additional benefits compared to conventional treatment alone, for example by increasing anti-inflammatory microbial species in the gut , modulating the concentration of certain biological metabolites and more.  

    • Supports fat metabolism and sports performance : An 8-week course of B. lactis supplementation combined with exercise training showed positive changes in fatty acid metabolism in ski athletes . Concentrations of triglycerides, LDL-C, and bile acids were reduced, accompanied by a significant increase in short-chain fatty acids, which are considered healthy for the body. This was also accompanied by improved muscle strength and oxygen uptake during endurance exercise.  

    • Irritable bowel syndrome: Together with Lactobacillus acidophilus , B. lactis subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, especially through shorter and milder pain symptoms.  

    • Alzheimer's: One of the main triggers for Alzheimer's is beta-amyloid plaques in the brain. In a 6-week study on mice, it was found that taking B. lactis reduced beta-amyloid plaque burden throughout the brain . Additionally, a preventive effect on improving working memory was observed.  

    Recommended dosages and instructions for use  

    The optimal dosage of Bifidobac terium lactis may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    We at AgilNatur e have in our “ SynbioticAgil ” product that provides you with probiotics such as Bifidobacterium lactis , we also take care of prebiotics to achieve the best effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Bifidobacterium Lactis is considered safe for health , even in the elderly and children . However, some probiotics can rarely cause sepsis in certain at-risk groups. People with weak immune systems and babies are considered at-risk and should therefore avoid taking it without consulting a doctor.  

     

    Which AgilNature ® products contain Bifidobacterium lactis ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    5.9 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020 Mar 25;12(4):892. 

    1. Stenman, LK, Lehtinen, MJ, Meland, N., Christensen, JE, Yeung, N., Saarinen, MT, Courtney, M., Burcelin , R., Lähdeaho , M.-L., Linros , J., Apter, D., Scheinin , M., Smerud, HK, Rissanen, A. & Lahtinen, S. (2016). Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin , in Overweight and Obese Adults—Randomized Controlled Trial. EBioMedicine , 13, 190–200. 

    1. Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla -Pagà L, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, Ramón D, Arola L, Solà R. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2019 Sep;43(9):1863-1868. 

    1. Balaguer F, Enrique M, Llopis S, Barrena M, Navarro V, Álvarez B, Chenoll E, Ramón D, Tortajada M, Martorell P. Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF-1 pathway. Microb Biotechnol . 2022 Mar;15(3):805-816 . 

    1. Ban OH, Lee M, Bang WY, Nam EH, Jeon HJ, Shin M, Yang J, Jung YH. Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism. Mol Nutr Food Res. 2023 Feb;67(3 ):e 2200385. 

    1. Cheng J, Laitila A, Ouwehand AC. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review. Front Nutr . 2021 Dec 14;8:790561 . 

    1. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. 

    1. Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, Michels C, Madeira K, Voytena AP, Rossetto M, Ramlov F, de Castro Damásio D, Dal-Pizzol F. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023 Jun;15(3):738-748. 

    1. Xu B, Liang S, Zhao J, Li X, Guo J, Xin B, Li B, Huo G, Ma W. Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Function . 2022 Jun 6;13(11):6404-6418 . 

    1. Vitheejongjaroen P, Kasorn A, Puttarat N, Loison F, Taweechotipatr M. Bifidobacterium animalis MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats. Antioxidants (Basel). 2022 Oct 29;11(11):2146. 

    1. Nocerino R, De Filippis F, Cecere G, Marino A, Micillo M, Di Scala C, de Caro C, Calignano A, Bruno C, Paparo L, Iannicelli AM, Cosenza L, Maddalena Y, Della Gatta G, Coppola S, Carucci L, Ercolini D, Berni Canani R. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomized , double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan;51(1):110-120. 

    1. Wang, CH, Yen, HR, Lu, WL, Ho, HH, Lin, WY, Kuo, YW, Huang, YY, Tsai, SY, & Lin, HC (2022). Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Frontiers in endocrinology, 13, 754401. 

    1. Siddiqui R, Makhlouf Z, Alharbi AM, Alfahemi H, Khan NA. The Gut Microbiome and Female Health. Biology (Basel). 2022 Nov 21;11(11):1683 . 

    1. Sun B, Ma T, Li Y, Yang N, Li B, Zhou mSystems . 2022 Apr 26;7(2 ):e 0010022. 

    1. Li T, Rui Z, Mao L, Chang Y, Shao J, Chen Y, Han Q, Sui Nutrients. 2023 Oct 27;15(21):4554 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

    1. Zhao F, Guo Z, Kwok LY, Zhao Z, Wang K, Li Y, Sun Z, Zhao J, Zhang H. Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota. Eur J Nutr . 2023 Mar;62(2):965-976. 

    1. Cao J, Amakye WK, Qi C, Liu X, Ma J, Ren J. Bifidobacterium Lactis Probio-M8 regulates gut microbiota to alleviate Alzheimer's disease in the APP/PS1 mouse model. Eur J Nutr . 2021 Oct;60(7):3757-3769. 

    1. Tsai HY, Wang YC, Liao CA, Su CY, Huang CH, Chiu MH, Yeh YT. Safety and the probiotic potential of Bifidobacterium animalis CP-9. J Food Sci. 2022 May;87(5):2211-2228 . 

  • Bacillus Coagulans
    Agil Nature

    Bacillus coagulans

    Bacillus coagulans , formerly incorrectly referred to as Lactobacillus sporogenes , is a gram-positive bacterium of the family Bacillaceae that has the ability to form spores . The spores allow it to multiply in the intestines for a certain period of time and thus show its effect for longer . It is generally considered safe by the FDA.  

    What is Bacillus Coagulans for

    Bacillus coagulans is used as a probiotic. Probiotics are living microorganisms that, in certain quantities, offer health benefits. Thanks to its ability to form spores, it has a better chance of survival than other traditional probiotics such as Lactobacillus for example. The beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic are:  

    • Digestive aid: B. coagulans produces various enzymes that help us with digestion and bowel movements. Sometimes enzymes that can digest lactose, so that lactose intolerance can be relieved  
    • Antibacterial activity: B. coagulans produces antibacterial substances that inhibit the growth of pathogenic intestinal bacteria and instead allow beneficial bacteria to grow better in our intestines  
    • Immune system regulation: B. coagulans can normalize the activity of the immune system and thus have a positive effect on the immune system  

     

    More specific health benefits found in studies  

    • Cholesterol reduction: B. coagulans lowers blood cholesterol and has reduced weight gain on a fatty diet in mice.  
    • Inhibition of inflammation: By regulating the immune system, adding B. coagulans to mice protected against inflammation and oxidative damage in the intestine. The probiotic also showed a positive effect on the immune system in immunosuppressed mice, as can happen after chemotherapy.  
    • Rheumatism patients: This, together with the anti-inflammatory properties of the bacterium, indicated in a study that pain and symptom improvement in rheumatism patients whose joints are inflamed.  
    • Irritable Bowel Syndrome (IBS): Since B. coagulans has a good regulating effect on our intestinal microbiome, with which many diseases are associated, taking this probiotic in patients with the chronic intestinal inflammation “Irritable Bowel Syndrome” (IBS), which causes pain and Significantly reduced flatulence and improved quality of life by reducing other symptoms of the disease. A possible trigger for intestinal-related diseases can sometimes be the more frequent use of antibiotics, as this can disrupt our microbiome.  
    • Antibiotic-associated problems: B. coagulans prevented microbiome disruption and antibiotic-associated diarrhea in 71% of children, while in the experimental group it was only 38%.  
    • Skin health: In addition, an improvement in skin appearance and skin aging was discovered in mice when B. coagulans was consumed.

     

     

    Comparison with other probiotics  

    Bacillus coagulans differs from other probiotics such as Lactobacillus or Bifidobacterium in its ability to form spores. These spores are extremely heat and acid resistant, allowing Bacillus coagulans to survive passage through the acidic stomach and reach the intestines in active form. In comparison, many other probiotics are more sensitive to stomach acid and require special coating techniques to effectively enter the intestines.  

    Recommended dosages and instructions for use  

    The optimal dosage of Bacillus coagulans may vary based on individual health status and desired effect. Generally, dosages in dietary supplements are between 1 and 2 billion colony forming units (CFU) per day. For specific uses, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber supports the effects of Bacillus coagulans , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the intestine. Foods such as whole grains, vegetables and fruit are recommended. In addition, care should be taken to ensure adequate fluid intake.  

    Which AgilNature® products contain Bacillus coagulans? 

    Product 

    Crowd 

    NRV* 

    ProtectAgil  

    2 x 10 9 CFU***  

    ** 

     

    *Nutrient Reference Value = Percentage of the reference value according to Appendix XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = colony forming units  

     

    Literature: 

    1. Lee NK, Kim WS, Paik HD. Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier. Food Sci Biotechnol. 2019 Oct 8;28(5):1297-1305.  
    2. Jiang Cao, Zhiming Yu, Wenyin Liu, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen, Probiotic characteristics of Bacillus coagulans and associated implications for human health and diseases, Journal of Functional Foods, Volume 64, 2020, 103643, ISSN 1756- 4646.  
    3. Aminlari, L., Shekarforoush, SS, Hosseinzadeh, S. et al. Effect of Probiotics Bacillus coagulans and Lactobacillus plantarum on Lipid Profile and Feces Bacteria of Rats Fed Cholesterol-Enriched Diet. Probiotics & Antimicro. Prot. 11, 1163–1171 (2019).  
    4. Hun L. Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS. Postgrad Med. 2009 Mar;121(2):119-24.  
    5. La Rosa M, Bottaro G, Gulino N, et al. [Prevention of antibiotic-associated diarrhea with Lactobacillus sporogens and fructo-oligosaccharides in children. A multicentric double-blind vs placebo study] Minerva Pediatrica. 2003 Oct;55(5):447-452.  
    6. Gupta AK, Maity C. Efficacy and safety of Bacillus coagulans LBSC in irritable bowel syndrome: A prospective, interventional, randomized, double-blind, placebo-controlled clinical study [CONSORT Compliant]. Medicine (Baltimore). 2021 Jan 22;100(3):e23641.  
    7. Wang Y, Lin J, Cheng Z, Wang T, Chen J, Long M. Bacillus coagulans TL3 Inhibits LPS-Induced Caecum Damage in Rat by Regulating the TLR4/MyD88/NF-κB and Nrf2 Signal Pathways and Modulating Intestinal Microflora. Oxide Med Cell Longev. 2022 Feb 7;2022:5463290.  
    8. Zhao Z, Sun M, Cui X, Chen J, Liu C, Zhang Sci Rep. 2023 Jul 10;13(1):11181.  
    9. Mandel DR, Eichas K, Holmes J. Bacillus coagulans: a viable adjunct therapy for relieving symptoms of rheumatoid arthritis according to a randomized, controlled trial. BMC Complement Altern Med. 2010 Jan 12;10:1.  
    10. Hiramoto K, Kubo S, Tsuji K, Sugiyama D, Iizuka Y, Hamano H. The Effect of Bacillus coagulans Induced Interactions among Intestinal Bacteria, Metabolites, and Inflammatory Molecules in Improving Natural Skin Aging. Dermatopathology (Basel). 2023 Sep 28;10(4):287-302.