Lactobacillus paracasei

Lactobacillus paracasei

Overview :  

Lactobacillus paracasei , is a gram-positive lactic acid bacterium of the family Lact obacillac eae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

Lactobacillus paracasei finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines . As a probiotic, L. paracasei especially found in fermented vegetables or dairy products such as kefir. L. paracasei survives the gastrointestinal tract well and can survive there for up to 3 days.  

Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

  • Supports dental health: Streptococcus mutans is the primary bacterium responsible for caries formation. L. paracasei demonstrated inhibitory activity against this bacterium by attaching to it and causing it to clump together. This prevents S. mutans from adhering to the tooth and allows it to be washed away with saliva or when brushing.  

  • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. paracasei promotes a It promotes a healthier balance in the intestines and increases the diversity of the intestinal flora. Likewise, the concentration of healthy, short-chain fatty acids in the intestines increases. Therefore, L. paracasei may be helpful in motility disorders of the gastrointestinal tract.  

  • Inhibits pathogens : L. paracasei inhibits the growth of certain pathogens such as E. coli , which is often associated with diarrhea .  

  • Weight control: Through its positive impact on intestinal health , L. paracsaei also positively influences weight. L. paracasei exhibits anti-obesity properties, alleviating obesity in mice by influencing fatty acid metabolism. In the study, 10 weeks of supplementation with the probiotic showed similar results to treatment with drugs such as orlistat .  

  • Immune system regulation: It is believed that L. paracasei can have a positive effect on the immune system and could have a supportive or preventative effect in diseases . For example, against viral infections, where an infection with the influenza virus could be better managed in mice . The potential of L. paracasei to improve resistance to common cold infections was also shown in test subjects . It is also used in allergy-related inflammation of the nasal mucosa . L. paracasei a positive influence is suspected.  

  • Cardiometabolic benefits: Supplementation with L. paracasei demonstrated positive effects on several cardiometabolic risk factors, including a reduction in cholesterol levels, which was associated with improved endothelial function by up to 5% in subjects. Furthermore, 12 weeks of supplementation also showed an improvement in metabolic syndrome (symptoms such as obesity, hypertension , and impaired glucose and lipid metabolism) , as both a reduced severity and a lower frequency of the syndrome were observed in subjects.  

Further studies  

Other health benefits found and suspected in studies include :  

  • Irritable bowel syndrome: Together with Bifidobacterium longum half L. paracasei Subjects after 8 weeks of use , to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life by Relief of gastrointestinal symptoms and improvement of psychological well -being .  

  • Bone health : Ovariectomy (OOP) and postmenopause are associated with osteoporosis, which is a loss of bone density and increases the risk of bone fractures. Studies have shown that L. paracasei reduces bone loss in oophorectomy by reducing inflammation, thus offering hope as a treatment or preventative method for postmenopausal osteoporosis.  

  • Hyperuricemia: Hyperuricemia, which is an elevated level of uric acid in the blood that can lead to gout, causes an imbalance in the intestinal flora by increasing pathogenic bacteria and decreasing diversity. L. paracasei was shown to repair precisely this imbalance in experiments, reversing organ damage and alleviating inflammatory symptoms in hyperuricemia mice .  

The optimal dosage of Lactobacillus paracasei can vary depending on individual health status and desired effect. Generally, dosages in supplements range from 1 to 2 billion colony-forming units (CFU) per day.  

Nutritional recommendations to support the effect  

A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus paracasei , to ensure the best possible effect. Our product, SynbioticAgil, contains additionally the prebiotic inulin.  

Dangers of taking  

The intake of Lactobacillus paracasei is considered safe , even for the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

 

Which AgilNature ® products contain Lactobacillus paracasei ? 

product 

Crowd 

NRV * 

SynbioticAgil  

7.17 x 10 9 CFU per daily ration (6 capsules)  

** 

 

* Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

** No recommendation available.  

*** CFU = Colony Forming Units  

 

Literature :  

  1. Chen JF, Hsia KC, Kuo YW, Chen SH, Huang YY, Li CM, Hsu YC, Tsai SY, Ho HH. Safety Assessment and Probiotic Potential Comparison of Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus plantarum LPL28, Lactobacillus acidophilus TYCA06, and Lactobacillus paracasei ET-66. Nutrients. 2023 Dec 29;16(1):126 . 

  1. Radicioni M, Koirala R, Fiore W, Leuratti C, Guglielmetti S, Arioli S. Survival of L. casei DG® (Lactobacillus paracasei CNCMI1572) in the gastrointestinal tract of a healthy pediatric population. Eur J Nutr . 2019 Dec;58(8):3161-3170. 

  1. Dehghani Champiri I, Bamzadeh Z, Rahimi E, Rouhi L. Lacticaseibacillus paracasei LB12, a Potential Probiotic Isolated from Traditional Iranian Fermented Milk ( Doogh ). Curr Microbiol . 2023 Sep 2;80(10):333. 

  1. Zhao Z, Wu J, Sun Z, Fan J, Liu F, Zhao W, Liu WH, Zhang M, Hung WL. Postbiotics Derived from L. paracasei ET-22 Inhibit the Formation of S. mutans Biofilms and Bioactive Substances : An Analysis. Molecules . 2023 Jan 27;28(3):1236 . 

  1. A Caridi, Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei , Journal of Industrial Microbiology and Biotechnology, Volume 29, Issue 6, 1 December 2002, Pages 303–308. 

  1. Cao J, Liu Q, Hao H, Bu Y, Tian X, Wang T, Yi H. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice. Front Immunol. 2022 Jul 6;13:940228 . 

  1. Cheng S, Li H, Ding Y, Huo J, Zheng Y, Jiang Y, Zhang Y, Man C. The Probiotic Combination of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 Alleviates Gastrointestinal Motility Disorder via Improving Gut Microbiota. Nutrients. 2023 Feb 7;15(4):839 . 

  1. Shin YJ, Bae JM, Cho HR, Mahoro P, Kim HH, Kim SH, Kim TH, Bae MJ. Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei , L. casei 431 on High-Fat Diet-Induced Obese Rats. J Med Food. 2023 Jul;26(7):445-453 . 

  1. Yang J, Huang J, Huang Z, Xu Y, Li W, Zhu S, Zhao Y, Ye B, Liu L, Zhu J, Xia M, Liu Y. Cardiometabolic benefits of Lacticaseibacillus paracasei 8700:2: A randomized double-blind placebo-controlled trial. Clin Nutr . 2023 Sep;42(9):1637-1646. 

  1. Kim S, Lee S, Kim TY, Lee SH, Seo SU, Kweon MN. Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection. Microbiomes. 2023 Nov 23;11(1):260. 

  1. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel- Higounenc I, Guéniche A. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defenses . Benef Microbes. 2014 Jun 1;5(2):129-36 . 

  1. Güvenç IA, Muluk NB, Mutlu FŞ, et al. Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis . American Journal of Rhinology & Allergy. 2016;30(5 ):e 157-e175. 

  1. Murata M, Kondo J, Iwabuchi N, Takahashi S, Yamauchi K, Abe F, Miura K. Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. Benef Microbes. 2018 Dec 7;9(6):855-864 . 

  1. Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl SH, Farman HH, Movérare-Skrtic S, Islander U, Sjögren K. Probiotics protect mice from ovariectomy-induced cortical bone loss . PLoS One . 2014 Mar 17;9(3 ):e 92368. 

  1. Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized , Placebo- Controlled Study. Nutrients . 2020 Apr 21;12(4):1159. 

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