Lactobacillus rhamnosus

Lactobacillus rhamnosus

Overview :  

Lactobacillus rhamnosus , formerly a subspecies of Lactobacillus casei considered , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Since the bacterium's discovery, it has been the most studied probiotic bacterium in the world, with a large number of studies.  

Lactobacillus rhamnosus finds Its main use is as a probiotic . Probiotics are living microorganisms that, in certain quantities, provide health benefits. for example by influencing the intestinal microbiome . It is worth mentioning that the current scientific view is that Lactobacillus rhamnosus is only a temporary resident in our intestines and after taking it as a probiotic does not remain permanently in the intestines once you stop taking it.  

Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

  • Promotes intestinal health: L. rhamnosus In studies, it repaired an already damaged protective barrier in the colon and also stimulated the production of mucin , a building block of this barrier . In mice, this resulted in an improvement in intestinal disorders such as constipation . In addition, it regulates the intestinal flora by promoting the proliferation of beneficial bacteria and inhibiting the growth of harmful bacteria .  

  • Immune system regulation: L. rhamnosus In studies, it has been shown to stimulate the natural immune system and ensure balance. Thanks to its stimulating effect In studies on hamsters and mice, it showed a positive influence on diseases such as inflammatory reactions in rheumatoid arthritis, osteoporosis and chronic inflammation of the colon ( colitis )  

  • Respiratory diseases: Based on studies it is suspected that L . rhamnsosus may play a mild prophylactic role in the prevention and treatment of some respiratory diseases. Since underweight children are associated with a high risk of various infections, L . rhamnosus investigated in this context. Here, too, L . rhamnosus the risk of infection and the resulting respiratory diseases.  

  • Lowering blood pressure: In combination with Bifidobacterium lactis In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , L . rhamnosus therefore has a positive effect on blood pressure when taken over a longer period.  

  • Help with diarrhea: Several studies, both in children and adults, indicate an improvement in the duration and symptoms of diarrhea for various causes. Children infected with rotavirus had an improvement in the symptoms of diarrhea caused by L. rhamnosus had a lower risk of suffering from diarrhea symptoms lasting more than one week. Diarrhea is a major problem, especially during antibiotic treatment, but the risk has been reduced in adults with L . rhamnosus as a probiotic. Scientists therefore believe that the frequency, duration, and severity of diarrhea caused by L. rhamnosus can be reduced. The European Food Safety Authority confirms this after testing However, this was not the case in 2013 , so it cannot be said with certainty but is a guess .  

 

Further studies  

Other health benefits found and suspected in studies include :  

  • Positive influence on the gut-brain axis : It has recently been discovered that gut health influences the brain, as both influence each other through the gut-brain axis. In mice, L. rhamnosus positive influence on these by alleviating noise-induced cognitive deficits and because when taken at a young age, the offspring showed less anxious behavior .  

  • Insulin resistance: In a study on mice, L . rhamnsosus to regulate blood sugar by reducing insulin resistance. Additionally, they also showed lower weight gain compared to control mice.  

  • Lactose intolerance: A study showed that L . rhamnosus together with Bifidobacterium longum and vitamin B6, alleviated symptoms associated with lactose intolerance. These probiotics led to fewer constipation and bloating symptoms in the subjects.  

  • Liver-protective: Together with inosine , L. rhamnosus ameliorated alcohol-induced liver damage in mice .  

  • Atherosclerosis: By influencing fatty acid and ketone body metabolism , L. rhamnosus slowed the progression of atherosclerosis in an animal study.  

Recommended dosages and instructions for use  

The optimal dosage of Lactobacillus rhamnosus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day. For specific applications, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.   

Nutritional recommendations to support the effect  

A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

At AgilNature , we 've also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics like Lactobacillus rhamnosus , for maximum effect. Our product SynbioticAgil also contains the prebiotic inulin.  

Dangers of taking  

The consumption of Lactobacillus rhamnosus strains, marketed as probiotics, is considered safe. However, in rare cases, it can lead to sepsis in certain at-risk groups. People with weak immune systems and infants are considered at risk and should therefore avoid taking them.  

 

Which AgilNature ® products contain Lactobacillus rhamnosus ? 

product 

Crowd 

NRV * 

SynbioticAgil  

6 x 10 9 CFU per daily ration (6 capsules)  

** 

 

* Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

** No recommendation available.  

*** CFU = Colony Forming Units  

 

Literature :  

  1. GW Tannock, K. Munro et al.: Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. In: Applied and environmental microbiology. Volume 66, Number 6, June 2000, pp. 2578–2588, ISSN 0099-2240. 

  1. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017; 6(4):21. 

  1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

  1. Guandalini , Stefano; Pensabene, Licia; Zikri, Mona Abu*; Dias, Jorge Amil†; Casali, Luigi Gobio‡; Hoekstra, Hans§; Kolacek, Sanja÷; Massar, Karin§; Micetic –Turk, Dusanka; Papadopoulou, Alexandra#; de Sousa, Jaime Salazar**; Sandhu, Bhupinder††; Szajewska , Hanna‡‡; Weizman, Zvi§§. Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial. Journal of Pediatric Gastroenterology and Nutrition 30(1 ):p 54-60, January 2000. 

  1. Österlund, P., Ruotsalainen, T., Korpela, R. et al. Lactobacillus supplementation for diarrhea related to chemotherapy of colorectal cancer: a randomized study. Br J Cancer 97, 1028–1034 (2007). 

  1. Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persistent Functional Gastrointestinal Symptoms: A Randomized , Double-Blind, Cross-Over Study. Nutrients. 2019 Apr 19;11(4):886. 

  1. Arellano-García L, Macarulla MT, Cuevas-Sierra A, Martínez JA, Portillo MP, Milton- Laskibar I. Lactobacillus rhamnosus GG administration partially prevents diet-induced insulin resistance in rats: a comparison with its heat-inactivated parabiotic. Food Function . 2023 Oct 2;14(19):8865-8875. 

  1. Sapra L, Saini C, Das S, Mishra PK, Singh A, Mridha AR, Yadav PK, Srivastava RK. Lactobacillus rhamnosus (LR) ameliorates pulmonary and extrapulmonary acute respiratory distress syndrome (ARDS) via targeting neutrophils. Clin Immunol. 2024 Jan;258:109872 . 

  1. Kumpu , M., Kekkonen, R., Kautiainen , H. et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 66, 1020–1023 (2012). 

  1. Kara SS, Volkan B, Erten I. Lactobacillus rhamnosus GG can protect malnourished children. Benef Microbes. 2019 Apr 19;10(3):237-244. 

  1. Guo M , Liu H, Yu Y , Zhu Good Microbes. 2023 Jan-Dec;15(1):2190304 . 

  1. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023 Jul;228(4):152415. 

  1. Tong L, Zhang X, Hao H , Liu Q, Zhou Z, Liang Nutrients. 2021 Sep 23;13(10):3319 . 

  1. Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr . 2000 Feb;83(2):167-76. 

  1. Chen L, Li S, Peng C, Gui Q, Li J, Xu Z, Yang Y. Lactobacillus rhamnosus GG Promotes Recovery of the Colon Barrier in Septic Mice through Accelerating ISCs Regeneration. Nutrients. 2023 Jan 28;15(3):672. 

  1.  Gu Y, Qin X, Zhou G, Wang C, Mu C, Liu X, Zhong W , Xu Food Function . 2022 Nov 28;13(23):12144-12155. 

  1. Li X , Zheng P , Cao W, Cao Y, She X, Yang H, Ma K, Wu F , Gao Front Cell Infect Microbiol . 2023 Apr 26;13:1067367 . 

  1. Zhou B, Jin G, Pang X, Mo Q, Bao J, Liu T, Wu J, Xie R, Liu X, Liu J, Yang H , Xu Pharmacol Res. 2022 Mar;177:106090 . 

  1. Zhai T, Ren W, Wang P, Zheng L. Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis. Appl Microbiol Biotechnol . 2022 Dec;106(24):8233-8243 . 

  1. Zhu Y , Wang​ Toxicol Appl Pharmacol . 2022 Mar 15;439:115923 . 

  1. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło -Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. 

  1. Boggio Marzet C, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr . 2022 Feb;120(1 ):e 1-e7. English, Spanish. 

  1. Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for physicians. J Microbiol Immunol Infect. 2021 Aug;54(4):575-580. 

  1. Zhang B, Lynch B, Zhao J, Guo Y, Mak A. Lactobacillus rhamnosus MP108: Toxicological evaluation. J Food Sci. 2021 Jan;86(1):228-241. 

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