Vitamin C and zinc are two essential nutrients found in many foods and are important for a variety of body functions. In recent years, combining these two nutrients in the form of dietary supplements has gained popularity. But why does this combination make so much sense? In this article, we will explore the benefits of vitamin C and zinc individually and in combination.
Vitamin C : More than just an antioxidant
Vitamin C, also known as ascorbic acid, is a water-soluble vitamin found in many fruits and vegetables. It has made a name for itself thanks to its impressive antioxidant properties, which protect our bodies from the harmful effects of free radicals and reactive oxygen species. These unstable molecules, created during normal metabolic processes and through exposure to toxins and pollutants, have the potential to cause significant cellular damage. This damage can lead to premature aging and a variety of diseases.
But the role of vitamin C in our body goes far beyond its antioxidant abilities. It acts as a reducing agent, meaning that it is able to donate electrons to other molecules, thereby exerting its antioxidant effects. One of its prominent functions is its involvement in the synthesis of collagen. Collagen is an essential protein that provides structure and strength to skin, cartilage and bones. Vitamin C is essential for the hydroxylation of prolyl and lysyl residues in collagen. This specific process stabilizes the collagen molecule, which is crucial for maintaining the integrity and function of collagen in skin, bones and blood vessels. Additionally, vitamin C plays a key role in improving iron absorption from plant foods and strengthening the immune system to help it fight off disease.
Zinc : An essential trace element
Zinc, an essential mineral found in foods like meat, dairy, and nuts, is a biochemical powerhouse with a variety of functions in the human body. It serves as a cofactor for over 300 enzymes, meaning it is essential for these enzymes to function properly . These enzymes are involved in many different processes, from DNA replication and transcription of genes to cell division and protein biosynthesis.
In addition, zinc is central to DNA methylation, a fine-tuned process that regulates gene expression and thus influences cell function and development. This highlights its key role in cell division and repair, maintaining the integrity and functionality of our cells.
Another notable aspect of zinc is its profound role in the central nervous system. It has the ability to modulate the activity of neurotransmitters, neurons and synaptic transmissions. This makes it an indispensable factor for cognitive functions such as learning and memory.
But zinc's effects go beyond the central nervous system. It also plays a crucial role in the immune system. Zinc is essential for the development and function of neutrophils and natural killer cells, two key players in the immune system that are specialized in fighting infections. In addition, zinc supports wound healing and is crucial for maintaining the sense of taste and smell.
Synergism of vitamin C and zinc
The combined effects of vitamin C and zinc provide an impressive range of health benefits:
- Immune Support: Vitamin C promotes the function and production of white blood cells, while zinc is necessary for proper signaling in immune cells. Together they can strengthen the immune system and improve the defense against infections.
- Antioxidant boost: While vitamin C directly neutralizes free radicals, zinc plays a role in activating superoxide dismutase, an important antioxidant enzyme. Together they offer comprehensive protection against oxidative stress. The combined antioxidant properties of vitamin C and zinc can protect the body from oxidative stress, which can lead to chronic disease and premature aging.
- Neuroprotection: Both nutrients offer neuroprotective benefits. While vitamin C supports the production of neurotransmitters, zinc modulates neurotransmission and protects against neurotoxic damage. Neuroprotection protects our nerve cells from damage, reducing the risk of diseases such as Alzheimer's. A protected brain works more efficiently, improves memory and concentration and promotes general well-being. It also helps slow the aging process of the brain and aids recovery after injuries.
- Cardiovascular Health: Vitamin C supports the production of nitric oxide, a molecule that dilates blood vessels and regulates blood pressure. Zinc, in turn, supports the metabolism of fatty acids and protects against oxidative stress, which can lead to cardiovascular diseases.
- Skin health: Vitamin C supports collagen production, while zinc protects the skin from UV damage and is involved in cell regeneration. Together they can help maintain healthy skin. Their combination can also speed up the healing process and reduce the risk of scarring.
Recent research suggests that the combination of vitamin C and zinc may promote gut health by modulating the microbiome. This can potentially reduce the risk of inflammatory bowel disease and other gastrointestinal disorders.
In conclusion, the biochemical and physiological synergies of vitamin C and zinc are a stunning example of the complexity and balance of the human body . Taking them together can provide wide-ranging health benefits, from boosting the immune system to supporting cognitive function.
- Maggini, S et al. “A combination of high-dose vitamin C plus zinc for the common cold.” The Journal of international medical research vol. 40.1 (2012): 28-42. doi:10.1177/147323001204000104
- Granger, Matthew, and Peter Eck. “Dietary Vitamin C in Human Health.” Advances in food and nutrition research vol. 83 (2018): 281-310. doi:10.1016/bs.afnr.2017.11.006
- Ellinger, Sabine, and Peter Stehle. “Efficacy of vitamin supplementation in situations with wound healing disorders: results from clinical intervention studies.” Current opinion in clinical nutrition and metabolic care vol. 12.6 (2009): 588-95. doi:10.1097/MCO.0b013e328331a5b5
- Safieh Firouzi, Naseh Pahlavani, Jamshid Gholizadeh Navashenaq, Zachary Stephen Clayton, Mohammad Taghi Beigmohammadi, Mahsa Malekahmadi, The effect of Vitamin C and Zn supplementation on the immune system and clinical outcomes in COVID-19 patients, Clinical Nutrition Open Science, Volume 44, 2022, Pages 144-154, ISSN 2667-2685, https://doi.org/10.1016/j.nutos.2022.06.006 .
- Gromova, OA et al. “Synergistic application of zinc and vitamin C to support memory, attention and the reduction of the risk of the neurological diseases]. Zhurnal neurology and psikhiatrii imeni SS Korsakova vol. 117.7 (2017): 112-119. doi:10.17116/jnevro201711771112-119
- Fantacone, M.L.; Lowry, MB; Uesugi, S.L.; Michels, A.J.; Choi, J.; Leonard, SW; Gombart, SK; Gombart, J.S.; Bobe, G.; Gombart, AF The Effect of a Multivitamin and Mineral Supplement on Immune Function in Healthy Older Adults: A Double-Blind, Randomized, Controlled Trial. Nutrients 2020, 12 , 2447. https://doi.org/10.3390/nu12082447
- Maselli del Giudice, A.; La Mantia, I.; Barbara, F.; Ciccarone, S.; Ragno, MS; de Robertis, V.; Cariti, F.; Barbara, M.; D'Ascanio, L.; Di Stadio, A. Use of Nutraceuticals in Elderly to Fight Inflammation and Immuno-Senescence: A Randomized Case-Control Study. Nutrients 2022, 14, 3476. https://doi.org/10.3390/nu14173476
- Skrovanek, Sonja et al. “Zinc and gastrointestinal disease.” World journal of gastrointestinal pathophysiology vol. 5.4 (2014): 496-513. doi:10.4291/wjgp.v5.i4.496
- Aditi, A., & Graham, D.Y. (2012). Vitamin C, gastritis, and gastric disease: a historical review and update. Digestive diseases and sciences, 57(10), 2504–2515. https://doi.org/10.1007/s10620-012-2203-7