
Bifidobacterium lactis
Bifidobacterium lactis , also Bifidobacterium animalis ssp . lactis , is a gram-positive lactic acid bacterium of the family Bifidobacteriaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.
Bifidobacterium animalis ssp . lactis finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . B. lactis is in abundant products used, mainly in dairy products . For example , it is also used in some yogurts in Lidl , listed as " Bifidobacterium BB-12" or in the prominent probiotic Activia yogurts. It is believed that B. lactis the gastrointestinal passage survived well and also has the potential to colonize the intestinal flora over a longer period of time . When taken with inulin, a concomitant dietary fiber, B. lactis was found in stool samples even two weeks after ingestion, indicating successful , long-term colonization in the intestine .
Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:
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Provides digestive support: B. lactis Helps digest fiber and plant substances . Since they are not among the bacteria that produce gas during digestion, they can divert fermentation in the large intestine to a non-gaseous end product and thus reduce potential flatulence. In a study on elderly people who consumed 1 x 10 9 CFU/day of B. lactis ( our SynbioticAgil contains 6 times that amount!) , more regular bowel movements were found on 26.9% of days . The number of test subjects who had normal bowel movements on more than 30% of days increased by 114% .
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Help with diarrhea: In addition to helping with constipation, A prominent feature of B. lactis is its ability to help with diarrhea. Especially in the elderly , but also in young children and those with antibiotic-associated problems, B. lactis helped to normalize bowel movements. In patients who underwent a 14-day antibiotic therapy and B. lactis income, the strength and risk possible diarrhea symptoms . The risk decreased to 10.8%, compared to the control group, which had a 15.56% risk. The duration also decreased to approximately 2 days instead of 4.
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Promotes intestinal health: An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. This imbalance is believed to be related to obesity and weight regulation. B. lactis promotes a healthy balance in the gut and supports its protective function. This keeps bacteria in the gut and reduces the risk of inflammation. According to a study, B. lactis as a probiotic, the intestinal flora of overweight subjects is adapted to the intestinal flora composition that is usually associated with a slimmer phenotype .
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Weight control: Through its positive influence on intestinal health , B. lactis also positively influences weight. Supplementation with B. lactis According to studies, it leads to a significant reduction in total body fat mass , food intake , and waist circumference. Fat deposits are particularly reduced in the abdominal area. This is also reflected in the BMI, which was reduced with long-term consumption of B. lactis . Studies assume that fat deposits are reduced due to the positive influence of B. lactis on fatty acid metabolism.
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Immune system regulation: It is suspected that B. lactis can help regulate the immune response against pathogens. Laboratory experiments have shown an improvement in the immune response against pathogens such as S. typhimurium , which is often involved in food poisoning due to poor food hygiene. B. lactis has also been shown to be effective against oxidative stress . helpful in rats .
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Respiratory symptoms of colds : Studies on toddlers and schoolchildren suggest that B. lactis could help increase the organism's resistance to common infections by strengthening the immune system . According to the studies , B. lactis also reduce the frequency and duration of respiratory infections.
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Lowering blood pressure: In combination with Lactobacillus rhamnosus In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , B. lactis may therefore have a positive effect on blood pressure when taken over a longer period of time.
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Baby colic: Known as baby colic , or three-month colic , is a period in which babies cry excessively, thought to be caused by abdominal pain , which may be related to the microbiome in the gut. Giving babies B. lactis halved the risk of colic in 80 percent of cases. the length of crying phases. The babies' stools also improved. ( Even though B. lactis is considered beneficial for children and babies, you should consult a doctor before taking it .)
Further studies
Other health benefits found and suspected in studies include :
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Type 1 diabetes : According to one study, a six-month supplementation of a mixture of different probiotics, including B. lactis , with concomitant insulin therapy helped improve insulin therapy. Conventional insulin therapy plus probiotics reduced diabetes symptoms by better stabilizing blood sugar levels and lowering HbA1c levels . It's important to note that probiotics are by no means a substitute for insulin therapy, but the right probiotics can potentially enhance it!
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Women's health : Together with other probiotics in the mix, B. lactis A positive effect on vascular function and arterial stiffness in overweight postmenopausal women was also shown . In addition, an improvement in bone metabolism was observed in postmenopausal osteoporosis with reduced inflammation.
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Coronary heart disease: The simultaneous Taking B.lactis with a conventional therapy regimen ( with atorvastatin and Metoprolol ) is thought to offer additional benefits compared to conventional treatment alone, for example by increasing anti-inflammatory microbial species in the gut , modulating the concentration of certain biological metabolites and more.
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Supports fat metabolism and sports performance : An 8-week course of B. lactis supplementation combined with exercise training showed positive changes in fatty acid metabolism in ski athletes . Concentrations of triglycerides, LDL-C, and bile acids were reduced, accompanied by a significant increase in short-chain fatty acids, which are considered healthy for the body. This was also accompanied by improved muscle strength and oxygen uptake during endurance exercise.
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Irritable bowel syndrome: Together with Lactobacillus acidophilus , B. lactis subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, especially through shorter and milder pain symptoms.
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Alzheimer's: One of the main triggers for Alzheimer's is beta-amyloid plaques in the brain. In a 6-week study on mice, it was found that taking B. lactis reduced beta-amyloid plaque burden throughout the brain . Additionally, a preventive effect on improving working memory was observed.
Recommended dosages and instructions for use
The optimal dosage of Bifidobac terium lactis may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.
Nutritional recommendations to support the effect
A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.
We at AgilNatur e have in our “ SynbioticAgil ” product that provides you with probiotics such as Bifidobacterium lactis , we also take care of prebiotics to achieve the best effect. Our product SynbioticAgil contains additionally the prebiotic inulin.
Dangers of taking
The intake of Bifidobacterium Lactis is considered safe for health , even in the elderly and children . However, some probiotics can rarely cause sepsis in certain at-risk groups. People with weak immune systems and babies are considered at-risk and should therefore avoid taking it without consulting a doctor.
Which AgilNature ® products contain Bifidobacterium lactis ?
product |
Crowd |
NRV * |
SynbioticAgil |
5.9 x 10 9 CFU per daily ration (6 capsules) |
** |
* Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.
** No recommendation available.
*** CFU = Colony Forming Units
Literature :
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Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 .
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Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020 Mar 25;12(4):892.
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Stenman, LK, Lehtinen, MJ, Meland, N., Christensen, JE, Yeung, N., Saarinen, MT, Courtney, M., Burcelin , R., Lähdeaho , M.-L., Linros , J., Apter, D., Scheinin , M., Smerud, HK, Rissanen, A. & Lahtinen, S. (2016). Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin , in Overweight and Obese Adults—Randomized Controlled Trial. EBioMedicine , 13, 190–200.
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Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla -Pagà L, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, Ramón D, Arola L, Solà R. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2019 Sep;43(9):1863-1868.
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Balaguer F, Enrique M, Llopis S, Barrena M, Navarro V, Álvarez B, Chenoll E, Ramón D, Tortajada M, Martorell P. Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF-1 pathway. Microb Biotechnol . 2022 Mar;15(3):805-816 .
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Ban OH, Lee M, Bang WY, Nam EH, Jeon HJ, Shin M, Yang J, Jung YH. Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism. Mol Nutr Food Res. 2023 Feb;67(3 ):e 2200385.
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Cheng J, Laitila A, Ouwehand AC. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review. Front Nutr . 2021 Dec 14;8:790561 .
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Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110.
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Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, Michels C, Madeira K, Voytena AP, Rossetto M, Ramlov F, de Castro Damásio D, Dal-Pizzol F. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023 Jun;15(3):738-748.
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Xu B, Liang S, Zhao J, Li X, Guo J, Xin B, Li B, Huo G, Ma W. Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Function . 2022 Jun 6;13(11):6404-6418 .
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Vitheejongjaroen P, Kasorn A, Puttarat N, Loison F, Taweechotipatr M. Bifidobacterium animalis MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats. Antioxidants (Basel). 2022 Oct 29;11(11):2146.
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Nocerino R, De Filippis F, Cecere G, Marino A, Micillo M, Di Scala C, de Caro C, Calignano A, Bruno C, Paparo L, Iannicelli AM, Cosenza L, Maddalena Y, Della Gatta G, Coppola S, Carucci L, Ercolini D, Berni Canani R. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomized , double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan;51(1):110-120.
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Wang, CH, Yen, HR, Lu, WL, Ho, HH, Lin, WY, Kuo, YW, Huang, YY, Tsai, SY, & Lin, HC (2022). Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Frontiers in endocrinology, 13, 754401.
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Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363.
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Zhao F, Guo Z, Kwok LY, Zhao Z, Wang K, Li Y, Sun Z, Zhao J, Zhang H. Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota. Eur J Nutr . 2023 Mar;62(2):965-976.
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