Hashimoto's thyroiditis

August 04, 2023
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Hashimoto's thyroiditis: A comprehensive look at the autoimmune disease and its impact on vitamin and mineral deficiencies  


Hashimoto's thyroiditis is an autoimmune disease that affects the thyroid gland and leads to an underactive thyroid. This complex condition can affect the body in a variety of ways and requires a holistic approach, including the role of vitamins and minerals. In this article, we examine science-based evidence about the link between Hashimoto's thyroiditis and vitamin and mineral deficiencies.  



Causes and pathophysiology:  

The exact cause of Hashimoto's thyroiditis is not fully understood, but it is believed that a combination of genetic, environmental, and immunological factors play a role. In this autoimmune disease, the immune system attacks the thyroid gland by producing antibodies against certain thyroid proteins. This leads to chronic inflammation of the thyroid gland, which over time can damage thyroid tissue and lead to underproduction of thyroid hormones.  


Symptoms and Diagnosis:  

Symptoms of Hashimoto's thyroiditis are often nonspecific and can be mistaken for other health conditions. Common symptoms include fatigue, weight gain, hair loss, dry skin, constipation, and sensitivity to cold. Some sufferers may also develop a goiter or swelling in the neck area.  

Hashimoto's thyroiditis is usually diagnosed through a combination of blood tests and imaging tests. Typically, thyroid hormone levels (T3 and T4) and thyroid-stimulating hormone (TSH) are measured. In addition, antibodies against thyroid proteins such as thyroglobulin (TG) and thyroid peroxidase (TPO) are detected. An ultrasound scan of the thyroid gland may also be done to assess the structure and any changes in the tissue.  


Treatment options:  

Treatment of Hashimoto's thyroiditis aims to normalize thyroid hormones and relieve symptoms. This is usually achieved by administering levothyroxine, a synthetic thyroid hormone that compensates for the lack of the body's own hormones.  


Diet and lifestyle:  

In addition to drug therapy, diet can play an important role in managing Hashimoto's thyroiditis. There is no specific "Hashimoto Diet," but it is recommended to focus on a balanced diet rich in fresh fruits, vegetables, whole grains, healthy fats, and lean protein. Some studies have shown that a gluten-free diet may be beneficial for some Hashimoto's patients, as gluten may increase inflammation and impair thyroid function. However, it is important that individual differences are taken into account and a gluten-free diet should only be considered after consulting a doctor or nutritionist.  


Vitamin and mineral deficiencies in Hashimoto's thyroiditis:

Various scientific studies have shown that Hashimoto's thyroiditis can be linked to vitamin and mineral deficiencies. Here are some key nutrients involved in Hashimoto's:  

Vitamin D: Vitamin D deficiency is common in Hashimoto's patients. Vitamin D plays a crucial role in the immune system and is important for the regulation of inflammatory reactions in the body. Research has shown that adequate vitamin D intake in Hashimoto's patients can be associated with improved thyroid function and a reduction in inflammatory responses.  

Selenium: Selenium is an essential trace element that is required for normal thyroid function and the conversion of thyroid hormones. Studies have shown that people with Hashimoto's thyroiditis often have lower levels of selenium. Adequate selenium supplementation could help reduce inflammation in the thyroid and improve thyroid function.  

Inositol: Inositol is a carbohydrate related to vitamin B8 and plays an important role in various functions in the body such as fat metabolism and muscle and nerve function. Studies have shown that taking myo-inositol together with selenium shows an improvement in the physical symptoms of hypothyroidism that selenium alone does not show. Taking myo-inositol together with selenium can also have a positive effect on the course of the autoimmune disease.  

Zinc: Zinc is another important trace element that is important for the immune system and thyroid function. A deficiency in zinc can increase the risk of autoimmune diseases, including Hashimoto's thyroiditis. Zinc supplementation could therefore play a supportive role in reducing inflammatory processes and improving thyroid function.  

Vitamin B12: Vitamin B12 is a water-soluble vitamin that is essential for the formation of DNA and red blood cells, as well as for nerve function. A lack of vitamin B12 can lead to exhaustion and fatigue, which can also affect Hashimoto's patients. Vitamin B12 supplementation might help alleviate these symptoms.


In summary, one could say that Hashimoto's thyroiditis is a complex autoimmune disease that can significantly impair the quality of life of those affected. In addition to drug therapy, nutrition plays an important role in overcoming the disease. A balanced diet tailored to individual needs, as well as taking into account potential vitamin and mineral deficiencies, could help support thyroid function and reduce inflammatory responses. It is important that people with Hashimoto's thyroiditis receive holistic care and adjust their diet and lifestyle in collaboration with qualified health professionals to ensure the best possible treatment.  



  • Botelho, Ilka Mara Borges et al. "Vitamin D in Hashimoto's thyroiditis and its relationship with thyroid function and inflammatory status." Endocrine journal vol. 65.10 (2018): 1029-1037. doi:10.1507/endocrj.EJ18-0166
  • Tamer G, Arik S, Tamer I, & Coksert D (2019). Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid research, 12, 2.
  • Gärtner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW & Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibody concentrations. The Journal of Clinical Endocrinology & Metabolism, 87(4), 1687-1691.
  • Prasad, AS (2008). Zinc in human health: effect of zinc on immune cells. Molecular medicine, 14(5-6), 353-357.
  • Weiping T., et al. (2017). Evaluation of the therapeutic effect of zinc and selenium on patients with Hashimoto's thyroiditis complicated with hypothyroidism. Experimental and therapeutic medicine, 14(2), 1223-1226.
  • Nair, RR, & Duffield, A (2019). Vitamin B12 deficiency and Hashimoto's thyroiditis: a chance association?. Endocrinology, Diabetes & Metabolism Case Reports, 2019.
  • Jabbar A, Yawar A, Waseem S, Islam N, Ul Haque N, Zuberi L, & Khan A (2014). Vitamin B12 deficiency common in primary hypothyroidism. Journal of the Pakistan Medical Association, 64(8), 913-916.
  • Hu, Shiqian, and Margaret P Rayman. "Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis." Thyroid : official journal of the American Thyroid Association vol. 27.5 (2017): 597-610. doi:10.1089/thy.2016.0635
  • Godhwani, Anika et al. "Does a Gluten-Free Diet Reduce Symptoms of Autoimmune Thyroid Disease?." American family physician vol. 108.1 (2023): 87-88.
  • Li, Qiuxian et al. "Emerging trends and hot spots in autoimmune thyroiditis research from 2000 to 2022: A bibliometric analysis." Frontiers in immunology vol. 13 953465. 11 Aug 2022, doi:10.3389/fimmu.2022.953465
  • Benvenga S, Feldt-Rasmussen U, Bonofiglio D, Asamoah E. Nutraceutical Supplements in the Thyroid Setting: Health Benefits beyond Basic Nutrition. nutrients . 2019; 11(9):2214. https://doi.org/10.3390/nu11092214


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1 comment

Really good article! Thanks


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