Methylsulfonylmethane (MSM), also called dimethylsulfone, is a sulfur-containing chemical compound that occurs naturally in the environment. This compound is found in foods such as milk and cooked vegetables. Through our diet, our own metabolism and that of our gut bacteria, MSM is also found naturally in our body in the blood and spinal fluid.  

Characteristics:  

MSM has been shown to have anti-inflammatory, antioxidant, immunomodulatory and anti-tumor properties in various studies. From a clinical perspective, the exact application is still uncertain and MSM is therefore currently only used in complementary medicine.  

However, there are studies in which MSM supplementation in humans has led to an increase in the good cholesterol, HDL, which could have a positive effect on the cardiovascular system. In both an animal and human study, MSM supplementation showed a reduction in oxidative stress on the muscles after exercise.  

The most common use of MSM is for joint health due to its beneficial anti-inflammatory properties. Several clinical studies have highlighted the benefits of MSM in relieving arthritis pain. Studies have found that MSM significantly contributes to reducing pain and physical function limitation in osteoarthritis patients.  

What is particularly interesting for use in our product DermAgil Beauty is that studies have shown that MSM leads to an improvement in the skin and signs of aging. The test subjects showed more elastic, hydrated skin with fewer wrinkles. Another study also showed an improvement in the shine of nails and hair as well as an improvement in hair volume.  

Dosage recommendation and possible side effects  

A daily dose of up to four grams is usually well tolerated and has only a few known and mild side effects. When applied externally, slight skin and eye irritation has been observed. An interaction between alcohol and MSM, such as increased sensitivity, may be possible, but needs to be researched in more detail.  

 

Which AgilNature® products contain methylsulfonylmethane? 

product	Crowd	NRV*
DermAgil Beauty	400 mg per daily ration (1 capsule each)	**

 

*Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No 1169/2011.  

** No recommendation available.  

 

Literature:  

1. Engelke UF, Tangerman A, Willemsen MA, Moscow D, Loss S, Mudd SH, Wevers RA (August 2005). "Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by one-dimensional (1)H and two-dimensional (1)H-(13)C NMR". NMR in Biomedicine. 18(5): 331–6. 
2. PharmaWiki - MSM (methylsulfonylmethane). https://www.pharmawiki.ch/wiki/index.php?wiki=MSM (accessed on December 16, 2023) 
3. Miller L, Thompson K, Pavlenco C, Mettu VS, Haverkamp H, Skaufel S, Basit A, Prasad B, Larsen J. The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Nutrients. 2021 Oct 15;13(10):3620. 
4. Muizzuddin N, Benjamin R. Beauty from within: Oral administration of a sulfur-containing supplement methylsulfonylmethane improves signs of skin aging. Int J Vitam Nutr Res. 2022 Jul;92(3-4):182-191. 
5. Lim, Eun Young; Hong, Dae Young; Park, Jin Hee; Young, Youn Hee; Darvin, Pramod; Kim, Sang Yoon; Well, Yoon Mi; Hwang, Tae Sook; Ye, Sang Kyu; Moon, Eon Soo; Cho, Byung Wook (2012). "Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways". PLOS ONE. 7(4):e33361. 
6. Barmaki S, Bohlooli S, Khoshkhahesh F, Nakhostin-Roohi B (April 2012). "Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity". The Journal of Sports Medicine and Physical Fitness. 52 (2): 170–4. 
7. Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, Bohlooli S (October 2011). "Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men". The Journal of Pharmacy and Pharmacology. 63 (10): 1290–4 
8. Liu X, Machado GC, Eyles JP, et al. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis, British Journal of Sports Medicine 2018;52:167-175. 
9. Butawan, M., Benjamin, RL & Bloomer, RJ Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement. Nutrients 9 , 290 (2017).