74 articles Found
  • Kollagen
    Agil Nature

    Kollagen

    Kollagen ist ein zentrales Strukturprotein des Körpers und essenziell für Haut, Gelenke und Bindegewebe. Dieser Beitrag beleuchtet wissenschaftlich fundiert die Funktion, klassische Quellen und aktuelle Entwicklungen rund um Kollagen – mit besonderem Fokus auf den modernen Ansatz, die körpereigene Kollagenbildung gezielt zu unterstützen. Erfahre, warum vegane Kollagen-Alternativen heute eine innovative und nachhaltige Lösung darstellen.

  • Maracuja
    Agil Nature

    Passion fruit

    Passion fruit impresses not only with its intensely exotic aroma but also with its diverse nutritional profile. In this entry of our vital substance encyclopedia, you'll learn interesting facts about the origin of this tropical fruit, its vitamins, minerals, and phytochemicals, as well as its sensory properties and nutritional aspects – presented in a well-founded, easy-to-understand, and health-claim-compliant manner.

  • Mango
    Agil Nature

    mango

    The mango is one of the most popular tropical fruits, prized for its sweet, fruity flavor and diverse nutritional profile. This entry in our nutrient encyclopedia provides valuable information about the origins of the mango, its vitamins, minerals, and phytochemicals, as well as its sensory and nutritional aspects – presented in a well-founded, easy-to-understand, and health-claim-compliant manner.

  • Lactobacillus rhamnosus
    Agil Nature

    Lactobacillus rhamnosus

    Overview :  

    Lactobacillus rhamnosus , formerly a subspecies of Lactobacillus casei considered , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Since the bacterium's discovery, it has been the most studied probiotic bacterium in the world, with a large number of studies.  

    Lactobacillus rhamnosus finds Its main use is as a probiotic . Probiotics are living microorganisms that, in certain quantities, provide health benefits. for example by influencing the intestinal microbiome . It is worth mentioning that the current scientific view is that Lactobacillus rhamnosus is only a temporary resident in our intestines and after taking it as a probiotic does not remain permanently in the intestines once you stop taking it.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health: L. rhamnosus In studies, it repaired an already damaged protective barrier in the colon and also stimulated the production of mucin , a building block of this barrier . In mice, this resulted in an improvement in intestinal disorders such as constipation . In addition, it regulates the intestinal flora by promoting the proliferation of beneficial bacteria and inhibiting the growth of harmful bacteria .  

    • Immune system regulation: L. rhamnosus In studies, it has been shown to stimulate the natural immune system and ensure balance. Thanks to its stimulating effect In studies on hamsters and mice, it showed a positive influence on diseases such as inflammatory reactions in rheumatoid arthritis, osteoporosis and chronic inflammation of the colon ( colitis )  

    • Respiratory diseases: Based on studies it is suspected that L . rhamnsosus may play a mild prophylactic role in the prevention and treatment of some respiratory diseases. Since underweight children are associated with a high risk of various infections, L . rhamnosus investigated in this context. Here, too, L . rhamnosus the risk of infection and the resulting respiratory diseases.  

    • Lowering blood pressure: In combination with Bifidobacterium lactis In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , L . rhamnosus therefore has a positive effect on blood pressure when taken over a longer period.  

    • Help with diarrhea: Several studies, both in children and adults, indicate an improvement in the duration and symptoms of diarrhea for various causes. Children infected with rotavirus had an improvement in the symptoms of diarrhea caused by L. rhamnosus had a lower risk of suffering from diarrhea symptoms lasting more than one week. Diarrhea is a major problem, especially during antibiotic treatment, but the risk has been reduced in adults with L . rhamnosus as a probiotic. Scientists therefore believe that the frequency, duration, and severity of diarrhea caused by L. rhamnosus can be reduced. The European Food Safety Authority confirms this after testing However, this was not the case in 2013 , so it cannot be said with certainty but is a guess .  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Positive influence on the gut-brain axis : It has recently been discovered that gut health influences the brain, as both influence each other through the gut-brain axis. In mice, L. rhamnosus positive influence on these by alleviating noise-induced cognitive deficits and because when taken at a young age, the offspring showed less anxious behavior .  

    • Insulin resistance: In a study on mice, L . rhamnsosus to regulate blood sugar by reducing insulin resistance. Additionally, they also showed lower weight gain compared to control mice.  

    • Lactose intolerance: A study showed that L . rhamnosus together with Bifidobacterium longum and vitamin B6, alleviated symptoms associated with lactose intolerance. These probiotics led to fewer constipation and bloating symptoms in the subjects.  

    • Liver-protective: Together with inosine , L. rhamnosus ameliorated alcohol-induced liver damage in mice .  

    • Atherosclerosis: By influencing fatty acid and ketone body metabolism , L. rhamnosus slowed the progression of atherosclerosis in an animal study.  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus rhamnosus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day. For specific applications, such as the treatment of irritable bowel syndrome, higher dosages may be appropriate.   

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNature , we 've also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics like Lactobacillus rhamnosus , for maximum effect. Our product SynbioticAgil also contains the prebiotic inulin.  

    Dangers of taking  

    The consumption of Lactobacillus rhamnosus strains, marketed as probiotics, is considered safe. However, in rare cases, it can lead to sepsis in certain at-risk groups. People with weak immune systems and infants are considered at risk and should therefore avoid taking them.  

     

    Which AgilNature ® products contain Lactobacillus rhamnosus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    6 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. GW Tannock, K. Munro et al.: Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. In: Applied and environmental microbiology. Volume 66, Number 6, June 2000, pp. 2578–2588, ISSN 0099-2240. 

    1. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics. 2017; 6(4):21. 

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Guandalini , Stefano; Pensabene, Licia; Zikri, Mona Abu*; Dias, Jorge Amil†; Casali, Luigi Gobio‡; Hoekstra, Hans§; Kolacek, Sanja÷; Massar, Karin§; Micetic –Turk, Dusanka; Papadopoulou, Alexandra#; de Sousa, Jaime Salazar**; Sandhu, Bhupinder††; Szajewska , Hanna‡‡; Weizman, Zvi§§. Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial. Journal of Pediatric Gastroenterology and Nutrition 30(1 ):p 54-60, January 2000. 

    1. Österlund, P., Ruotsalainen, T., Korpela, R. et al. Lactobacillus supplementation for diarrhea related to chemotherapy of colorectal cancer: a randomized study. Br J Cancer 97, 1028–1034 (2007). 

    1. Vitellio P, Celano G, Bonfrate L, Gobbetti M, Portincasa P, De Angelis M. Effects of Bifidobacterium longum and Lactobacillus rhamnosus on Gut Microbiota in Patients with Lactose Intolerance and Persistent Functional Gastrointestinal Symptoms: A Randomized , Double-Blind, Cross-Over Study. Nutrients. 2019 Apr 19;11(4):886. 

    1. Arellano-García L, Macarulla MT, Cuevas-Sierra A, Martínez JA, Portillo MP, Milton- Laskibar I. Lactobacillus rhamnosus GG administration partially prevents diet-induced insulin resistance in rats: a comparison with its heat-inactivated parabiotic. Food Function . 2023 Oct 2;14(19):8865-8875. 

    1. Sapra L, Saini C, Das S, Mishra PK, Singh A, Mridha AR, Yadav PK, Srivastava RK. Lactobacillus rhamnosus (LR) ameliorates pulmonary and extrapulmonary acute respiratory distress syndrome (ARDS) via targeting neutrophils. Clin Immunol. 2024 Jan;258:109872 . 

    1. Kumpu , M., Kekkonen, R., Kautiainen , H. et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr 66, 1020–1023 (2012). 

    1. Kara SS, Volkan B, Erten I. Lactobacillus rhamnosus GG can protect malnourished children. Benef Microbes. 2019 Apr 19;10(3):237-244. 

    1. Guo M , Liu H, Yu Y , Zhu Good Microbes. 2023 Jan-Dec;15(1):2190304 . 

    1. Tripathy A, Swain N, Padhan P, Raghav SK, Gupta B. Lactobacillus rhamnosus reduces CD8+T cell mediated inflammation in patients with rheumatoid arthritis. Immunobiology. 2023 Jul;228(4):152415. 

    1. Tong L, Zhang X, Hao H , Liu Q, Zhou Z, Liang Nutrients. 2021 Sep 23;13(10):3319 . 

    1. Gill HS, Rutherfurd KJ, Prasad J, Gopal PK. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr . 2000 Feb;83(2):167-76. 

    1. Chen L, Li S, Peng C, Gui Q, Li J, Xu Z, Yang Y. Lactobacillus rhamnosus GG Promotes Recovery of the Colon Barrier in Septic Mice through Accelerating ISCs Regeneration. Nutrients. 2023 Jan 28;15(3):672. 

    1.  Gu Y, Qin X, Zhou G, Wang C, Mu C, Liu X, Zhong W , Xu Food Function . 2022 Nov 28;13(23):12144-12155. 

    1. Li X , Zheng P , Cao W, Cao Y, She X, Yang H, Ma K, Wu F , Gao Front Cell Infect Microbiol . 2023 Apr 26;13:1067367 . 

    1. Zhou B, Jin G, Pang X, Mo Q, Bao J, Liu T, Wu J, Xie R, Liu X, Liu J, Yang H , Xu Pharmacol Res. 2022 Mar;177:106090 . 

    1. Zhai T, Ren W, Wang P, Zheng L. Lactobacillus rhamnosus GG protects against atherosclerosis by improving ketone body synthesis. Appl Microbiol Biotechnol . 2022 Dec;106(24):8233-8243 . 

    1. Zhu Y , Wang​ Toxicol Appl Pharmacol . 2022 Mar 15;439:115923 . 

    1. Cukrowska B, Ceregra A, Maciorkowska E, Surowska B, Zegadło -Mylik MA, Konopka E, Trojanowska I, Zakrzewska M, Bierła JB, Zakrzewski M, Kanarek E, Motyl I. The effectiveness of probiotic Lactobacillus rhamnosus and Lactobacillus casei strains in children with atopic dermatitis and cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study. Nutrients. 2021 Apr 1;13(4):1169. 

    1. Boggio Marzet C, Burgos F, Del Compare M, Gerold I, Tabacco O, Vinderola G. Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG. Arch Argent Pediatr . 2022 Feb;120(1 ):e 1-e7. English, Spanish. 

    1. Chiang MC, Chen CL, Feng Y, Chen CC, Lien R, Chiu CH. Lactobacillus rhamnosus sepsis associated with probiotic therapy in an extremely preterm infant: Pathogenesis and a review for physicians. J Microbiol Immunol Infect. 2021 Aug;54(4):575-580. 

    1. Zhang B, Lynch B, Zhao J, Guo Y, Mak A. Lactobacillus rhamnosus MP108: Toxicological evaluation. J Food Sci. 2021 Jan;86(1):228-241. 

  • Lactobacillus paracasei
    Agil Nature

    Lactobacillus paracasei

    Overview :  

    Lactobacillus paracasei , is a gram-positive lactic acid bacterium of the family Lact obacillac eae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus paracasei finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines . As a probiotic, L. paracasei especially found in fermented vegetables or dairy products such as kefir. L. paracasei survives the gastrointestinal tract well and can survive there for up to 3 days.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Supports dental health: Streptococcus mutans is the primary bacterium responsible for caries formation. L. paracasei demonstrated inhibitory activity against this bacterium by attaching to it and causing it to clump together. This prevents S. mutans from adhering to the tooth and allows it to be washed away with saliva or when brushing.  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. paracasei promotes a It promotes a healthier balance in the intestines and increases the diversity of the intestinal flora. Likewise, the concentration of healthy, short-chain fatty acids in the intestines increases. Therefore, L. paracasei may be helpful in motility disorders of the gastrointestinal tract.  

    • Inhibits pathogens : L. paracasei inhibits the growth of certain pathogens such as E. coli , which is often associated with diarrhea .  

    • Weight control: Through its positive impact on intestinal health , L. paracsaei also positively influences weight. L. paracasei exhibits anti-obesity properties, alleviating obesity in mice by influencing fatty acid metabolism. In the study, 10 weeks of supplementation with the probiotic showed similar results to treatment with drugs such as orlistat .  

    • Immune system regulation: It is believed that L. paracasei can have a positive effect on the immune system and could have a supportive or preventative effect in diseases . For example, against viral infections, where an infection with the influenza virus could be better managed in mice . The potential of L. paracasei to improve resistance to common cold infections was also shown in test subjects . It is also used in allergy-related inflammation of the nasal mucosa . L. paracasei a positive influence is suspected.  

    • Cardiometabolic benefits: Supplementation with L. paracasei demonstrated positive effects on several cardiometabolic risk factors, including a reduction in cholesterol levels, which was associated with improved endothelial function by up to 5% in subjects. Furthermore, 12 weeks of supplementation also showed an improvement in metabolic syndrome (symptoms such as obesity, hypertension , and impaired glucose and lipid metabolism) , as both a reduced severity and a lower frequency of the syndrome were observed in subjects.  

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium longum half L. paracasei Subjects after 8 weeks of use , to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life by Relief of gastrointestinal symptoms and improvement of psychological well -being .  

    • Bone health : Ovariectomy (OOP) and postmenopause are associated with osteoporosis, which is a loss of bone density and increases the risk of bone fractures. Studies have shown that L. paracasei reduces bone loss in oophorectomy by reducing inflammation, thus offering hope as a treatment or preventative method for postmenopausal osteoporosis.  

    • Hyperuricemia: Hyperuricemia, which is an elevated level of uric acid in the blood that can lead to gout, causes an imbalance in the intestinal flora by increasing pathogenic bacteria and decreasing diversity. L. paracasei was shown to repair precisely this imbalance in experiments, reversing organ damage and alleviating inflammatory symptoms in hyperuricemia mice .  

    The optimal dosage of Lactobacillus paracasei can vary depending on individual health status and desired effect. Generally, dosages in supplements range from 1 to 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus paracasei , to ensure the best possible effect. Our product, SynbioticAgil, contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus paracasei is considered safe , even for the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus paracasei ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    7.17 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Chen JF, Hsia KC, Kuo YW, Chen SH, Huang YY, Li CM, Hsu YC, Tsai SY, Ho HH. Safety Assessment and Probiotic Potential Comparison of Bifidobacterium longum subsp. infantis BLI-02, Lactobacillus plantarum LPL28, Lactobacillus acidophilus TYCA06, and Lactobacillus paracasei ET-66. Nutrients. 2023 Dec 29;16(1):126 . 

    1. Radicioni M, Koirala R, Fiore W, Leuratti C, Guglielmetti S, Arioli S. Survival of L. casei DG® (Lactobacillus paracasei CNCMI1572) in the gastrointestinal tract of a healthy pediatric population. Eur J Nutr . 2019 Dec;58(8):3161-3170. 

    1. Dehghani Champiri I, Bamzadeh Z, Rahimi E, Rouhi L. Lacticaseibacillus paracasei LB12, a Potential Probiotic Isolated from Traditional Iranian Fermented Milk ( Doogh ). Curr Microbiol . 2023 Sep 2;80(10):333. 

    1. Zhao Z, Wu J, Sun Z, Fan J, Liu F, Zhao W, Liu WH, Zhang M, Hung WL. Postbiotics Derived from L. paracasei ET-22 Inhibit the Formation of S. mutans Biofilms and Bioactive Substances : An Analysis. Molecules . 2023 Jan 27;28(3):1236 . 

    1. A Caridi, Selection of Escherichia coli-inhibiting strains of Lactobacillus paracasei subsp. paracasei , Journal of Industrial Microbiology and Biotechnology, Volume 29, Issue 6, 1 December 2002, Pages 303–308. 

    1. Cao J, Liu Q, Hao H, Bu Y, Tian X, Wang T, Yi H. Lactobacillus paracasei X11 Ameliorates Hyperuricemia and Modulates Gut Microbiota in Mice. Front Immunol. 2022 Jul 6;13:940228 . 

    1. Cheng S, Li H, Ding Y, Huo J, Zheng Y, Jiang Y, Zhang Y, Man C. The Probiotic Combination of Lacticaseibacillus paracasei JY062 and Lactobacillus gasseri JM1 Alleviates Gastrointestinal Motility Disorder via Improving Gut Microbiota. Nutrients. 2023 Feb 7;15(4):839 . 

    1. Shin YJ, Bae JM, Cho HR, Mahoro P, Kim HH, Kim SH, Kim TH, Bae MJ. Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei , L. casei 431 on High-Fat Diet-Induced Obese Rats. J Med Food. 2023 Jul;26(7):445-453 . 

    1. Yang J, Huang J, Huang Z, Xu Y, Li W, Zhu S, Zhao Y, Ye B, Liu L, Zhu J, Xia M, Liu Y. Cardiometabolic benefits of Lacticaseibacillus paracasei 8700:2: A randomized double-blind placebo-controlled trial. Clin Nutr . 2023 Sep;42(9):1637-1646. 

    1. Kim S, Lee S, Kim TY, Lee SH, Seo SU, Kweon MN. Newly isolated Lactobacillus paracasei strain modulates lung immunity and improves the capacity to cope with influenza virus infection. Microbiomes. 2023 Nov 23;11(1):260. 

    1. Benyacoub J, Bosco N, Blanchard C, Demont A, Philippe D, Castiel- Higounenc I, Guéniche A. Immune modulation property of Lactobacillus paracasei NCC2461 (ST11) strain and impact on skin defenses . Benef Microbes. 2014 Jun 1;5(2):129-36 . 

    1. Güvenç IA, Muluk NB, Mutlu FŞ, et al. Do Probiotics have a role in the Treatment of Allergic Rhinitis? A Comprehensive Systematic Review and Metaanalysis . American Journal of Rhinology & Allergy. 2016;30(5 ):e 157-e175. 

    1. Murata M, Kondo J, Iwabuchi N, Takahashi S, Yamauchi K, Abe F, Miura K. Effects of paraprobiotic Lactobacillus paracasei MCC1849 supplementation on symptoms of the common cold and mood states in healthy adults. Benef Microbes. 2018 Dec 7;9(6):855-864 . 

    1. Ohlsson C, Engdahl C, Fåk F, Andersson A, Windahl SH, Farman HH, Movérare-Skrtic S, Islander U, Sjögren K. Probiotics protect mice from ovariectomy-induced cortical bone loss . PLoS One . 2014 Mar 17;9(3 ):e 92368. 

    1. Lewis ED, Antony JM, Crowley DC, Piano A, Bhardwaj R, Tompkins TA, Evans M. Efficacy of Lactobacillus paracasei HA-196 and Bifidobacterium longum R0175 in Alleviating Symptoms of Irritable Bowel Syndrome (IBS): A Randomized , Placebo- Controlled Study. Nutrients . 2020 Apr 21;12(4):1159. 

  • Lactobacillus acidophilus
    Agil Nature

    Lactobacillus acidophilus

    Overview :  

    Lactobacillus acidophilus , is a gram-positive lactic acid bacterium of the family Lactobacillaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Lactobacillus acidophilus finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . This bacterium occurs naturally in our intestines, where it can break down bile acids. L. acidophilus is used as a probiotic. especially used in sour milk products , for example in yoghurts . Since L. acidophilus Because it prefers to live and be active at low pH levels , it survives the acids of the gastrointestinal tract well.  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Promotes intestinal health : An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. L. acidophilus produces antibacterial peptides that are effective against potentially pathogenic bacteria such as Escherichia coli. Staphylococcus aureus and Salmonella enteritidis . In addition , L. acidophilus pH , which can also inhibit the growth of many pathogens in the gut, as some prefer a more neutral or alkaline environment. This promotes a healthy balance in the gut.  

    • Lowers cholesterol: In some experiments, L. acidophilus has shown cholesterol-lowering effects and an inhibitory effect on atherosclerosis , which can lead to heart attacks due to cholesterol deposits in the blood vessels. Therefore, a supply of L. acidophilus could reduce the risk of cardiovascular disease.  

    • Intestinal inflammation: Colitis is a chronic inflammation of the intestine that can be triggered by a disrupted intestinal barrier, an imbalanced intestinal flora, and genetic susceptibility. The main treatment for such intestinal inflammations is probiotics, and L. acidophilus has also proven helpful here. Thanks to the immunomodulatory properties of L. acidophilus , it reduces inflammatory reactions in the body. The protective function of the intestine has also been strengthened in studies with L. acidophilus .  

    • Help with diarrhea: In combination with other antibiotics , especially other Lactobacillus species and Bifidobacterium species , L. acidophilus the risk of diarrhea in young children from 32% to 20%.  

    • Weight control: By positively influencing intestinal imbalance and other factors, L. acidophilus Supplementation also improved weight loss in mice with obesity and associated diseases . Improvements in energy, sugar, and lipid metabolism were also observed in this regard .  

    • Immune system regulation: L. acidophilus shows positive effects on the immune response by influencing inflammatory processes and immune response in some pathogens such as the fungal infection Candida albicans .  

    • Cholesterol-lowering : Some laboratory and animal studies show significant reduction of serum cholesterol by L. acidophilus Addition . However, the experiments show differences among themselves, so the specific cholesterol-lowering effect is not yet fully understood from a scientific perspective.  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Irritable bowel syndrome: Together with Bifidobacterium animalis ssp . lactis helped L. acidophilus Subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, particularly through shorter and milder pain symptoms , as well as other symptom relief.  

    • Lactose intolerance: L. acidophilus Studies have shown improved lactose digestion and relieved symptoms such as bloating and diarrhea.  

    • Osteoporosis : Age , as well as postmenopause in women , can lead to this bone disease, which causes brittle bones due to porous bones . Its immunomodulatory effect was shown in a mouse study L. acidophilus administration may improve bone architecture and increase mineral density . By influencing the balance of certain immune cells, L. acidophilus as a probiotic, have an osteo-protective effect, especially for women with postmenopausal osteoporosis.  

    • Rheumatism: In rheumatoid Arthritis, or rheumatism for short, is an inflammatory joint disease associated with pain and stiffness. The inflammatory reactions can also have harmful effects on other organs. While the exact mechanisms are still unclear, experiments suggest that long-term use of L. acidophilus may help with arthritis by counteracting the inflammatory reactions in the body and thus protecting against more serious damage.  

    • Dermatitis: Due to the anti-inflammatory response that L. acidophilus could promote in the body , the probiotic improved the progression of dermatitis, a skin inflammatory disease, in a mouse model.  

    • ADHD: In a 3-month study in ADHD subjects aged 6-16, additional supplementation with L. acidophilus When taking the drug Amotextin , improvements in therapy such as in the concentration of children are observed .  

    • Liver cancer : Through the production of valeric acid by L. acidophilus , a suppression of the growth of liver cancer cells was observed in mice .  

    Recommended dosages and instructions for use  

    The optimal dosage of Lactobacillus acidophilus may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    At AgilNatur e, we have also included prebiotics in our " SynbioticAgil " product, which provides you with probiotics such as Lactobacillus acidophilus , to ensure the best possible effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Lactobacillus acidophilus is considered safe for health , even in the elderly and children . The risk of developing antibiotic resistance is also considered low . However, in rare cases , some probiotics can cause sepsis, and certain Risk groups. People with weak immune systems and babies are considered to be at risk and should therefore refrain from taking the medication without consulting a doctor.  

     

    Which AgilNature ® products contain Lactobacillus acidophilus ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    4.41 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. SE Gilliland, ML Speck: Deconjugation of bile acids by intestinal lactobacilli. In: Applied and Environmental Microbiology. Volume 33, No. 1, 1977, ISSN 0099-2240, pp. 15-18, 

    1. Gao H, Li X, Chen X, Hai D, Wei C, Zhang L, Li P. The functional roles of Lactobacillus acidophilus in different physiological and pathological processes. J Microbiol Biotechnol . 2022 Oct 28;32(10):1226-1233. 

    1. Xing TL, Bian X, Ma CM, Yang Y, Liu Food Function . 2023 Mar 6;14(5):2472-2480. 

    1. Li P, Chen G, Zhang J, Pei C, Chen Y, Gong J, Deng S, Cai K, Li H, Wang D, Shen B, Xie Z, Liao Q. Live Lactobacillus acidophilus alleviates ulcerative colitis via the SCFAs/mitophagy/NLRP3 inflammasome axis. Food Function . 2022 Mar 7;13(5):2985-2997 . 

    1. Kye YJ, Lee SY, Kim HR, Lee BH, Park JH, Park MS, Ji GE, Sung MK. Lactobacillus acidophilus PIN7 paraprobiotic supplementation ameliorates DSS-induced colitis through anti-inflammatory and immune regulatory effects. J Appl Microbiol . 2022 Apr;132(4):3189-3200 . 

    1. Lukasik J, Dierikx T, Besseling -van der Vaart I, de Meij T, Szajewska H; Multispecies Probiotic in AAD Study Group. Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A Randomized Clinical Trial. JAMA Pediatrics . 2022 Sep 1;176(9):860-866. 

    1. Skrzydło-Radomańska B, Prozorow -Król B, Cichoż -Lach H, Majsiak E, Bierła JB, Kosikowski W, Szczerbiński M, Gantzel J, Cukrowska B. The Effectiveness of Synbiotic Preparation Containing Lactobacillus and Bifidobacterium Probiotic Strains and Short Chain Fructooligosaccharides in Patients with Diarrhea Predominant Irritable Bowel Syndrome-A Randomized Double-Blind, Placebo-Controlled Study. Nutrients. 2020 Jul 5;12(7):1999. 

    1. Li P, He Probiotics Antimicrob Proteins. 2023 Dec 5 . 

    1. Kang Y, Kang X , Yang H, Liu H, Yang X, Liu Q, Tian H, Xue Y, Ren P, Kuang Pharmacol Res. 2022 Jan;175:106020 . 

    1. Woo JS, Hwang SH, Yang S, Lee KH, Lee YS, Choi JW, Park JS, Jhun J, Park SH, Cho ML. Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway. Cell Commun Signal. 2023 Jun 14;21(1):135. 

    1. Lau HC, Zhang X, Ji F, Lin Y, Liang W, Li Q, Chen D, Fong W, Kang EBioMedicine . 2024 Feb;100:104952 . 

    1. Elhossiny RM, Elshahawy HH, Mohamed HM, Abdelmageed RI. Assessment of probiotic strain Lactobacillus acidophilus LB supplementation as adjunctive management of attention-deficit hyperactivity disorder in children and adolescents: a randomized controlled clinical trial. BMC Psychiatry. 2023 Nov 9;23(1):823 . 

    1. Paul AK, Paul A, Jahan R, Jannat K, Bondhon TA, Hasan A, Nissapatorn V, Pereira ML, Wilairatana P, Rahmatullah M. Probiotics and Amelioration of Rheumatoid Arthritis: Significant Roles of Lactobacillus casei and Lactobacillus acidophilus. Microorganisms. 2021 May 16;9(5):1070 . 

    1. Amdekar S, Singh V, Kumar A, Sharma P, Singh R. Lactobacillus acidophilus Protected Organs in Experimental Arthritis by Regulating the Pro-inflammatory Cytokines. Indian J Clin Biochem . 2014 Oct;29(4):471-8 . 

    1. Bungau SG, Behl T, Singh A, Sehgal A, Singh S, Chigurupati S, Vijayabalan S, Das S, Palanimuthu VR. Targeting Probiotics in Rheumatoid Arthritis. Nutrients. 2021 Sep 26;13(10):3376 . 

    1. Dar HY, Shukla P, Mishra PK, Anupam R, Mondal RK, Tomar GB, Sharma V, Srivastava RK. Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance. Bone Rep. 2018 Feb 5;8:46 -56 . 

    1. Kim WK, Jang YJ, Park S, Min SG, Kwon H, Jo MJ, Ko G. Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model. JMicrobiol .​ 2024 Feb;62(2):91-99 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

     

  • Inulin
    Agil Nature

    Inulin

    Origin and history :  

    Inulin is a polysaccharide produced in many plants and is a dietary fiber. It is also often found in foods today, for example, it is used in yogurt as a fat substitute and in some animal products , such as sausage , as a source of fiber. Due to its slightly sweet, subtle flavor, inulin is easy to incorporate into foods and products. Our bodies cannot break down inulin on their own; instead, it is fermented by intestinal bacteria into short-chain fatty acids, which are considered beneficial to health. Common plants that contain inulin are artichokes, onions, garlic, asparagus, bananas and many more. However, commercial insulin is extracted from the roots of chicory.  

    Consumption of fiber such as inulin is generally associated with a lower risk of overall mortality and a lower risk of cancer and cardiovascular disease. It is also believed to have a protective effect against diseases such as type 2 diabetes mellitus, obesity, hyperlipidemia, and hypertension. There is no official daily requirement for fiber, but the guideline is at least 30 g per day. In Germany, the average intake is 18-19 g, which is below the guideline. Therefore, it is important to educate yourself about possible fiber sources such as inulin and their sources, as well as to develop an awareness of your fiber intake.  

    Characteristics :  

    Inulin as a fiber can be used as a prebiotic. A prebiotic is like food for healthy intestinal bacteria and can be metabolized by them, promoting their growth and increasing the bacteria's health-promoting products. As such a source of fiber, it has positive effects on the digestive system & intestinal bacteria and can also form a protective film on the intestinal wall. Inulin is therefore often used in intestinal treatments and cleansing .  

    Numerous beneficial effects that have been discovered so far and are interesting as a prebiotic:  

    • Intestinal flora – Inulin helps regulate the intestinal microbiome by promoting the growth of healthy bacteria. A healthy gut also improves inflammatory responses in chronic intestinal diseases and improves constipation and bowel movements. Studies have also shown that inulin can reduce the risk of colon cancer. Better results were seen when inulin is taken with probiotics.  

    • Mineral intake​ and bone health – When taken in sufficient amounts over a long period of time, inulin is believed to improve calcium absorption in the body and thus has a positive effect on bone mineral density. Magnesium and iron absorption may also be enhanced. One study showed an 18% improvement in calcium absorption after 3 weeks of inulin supplementation. Improved calcium absorption also promotes bone health in postmenopausal women, for whom bone density is particularly problematic. Incorporating inulin into the diet could therefore reduce the risk of osteoporosis in later years. A daily intake of 8-10 g of inulin is believed to support calcium absorption and overall bone mineral content.  

    • Lipid metabolism – Inulin influences the regulation of lipid metabolism and thus has a positive effect on lowering blood lipids and cholesterol levels when elevated . Since high blood lipid levels are associated with atherosclerosis and other coronary heart diseases, inulin, like other fiber, can reduce the risk of these diseases .  

    • Diabetes mellitus type 2 – Inulin has been shown in studies to reduce long-term blood sugar and lower inflammatory markers in diabetic patients. Diseases such as type 2 diabetes mellitus are also usually associated with impaired intestinal flora and fermentation, which could be improved with inulin in a study after 6 weeks of supplementation.  

    • Weight regulation Inulin has demonstrated a positive effect on weight in many ways. Firstly, in animal models , fat deposits are broken down in an inulin - rich diet . Secondly , appetite is also a major factor in the development of obesity. Inulin increased satiety and improved subjective appetite assessment in overweight and obese children aged 11 to 12 years . Studies have shown that supplemental insulin intake in a weight-loss program improved weight loss. Also​​​ became​​​​ a n over weight​​​​​​​​​​​​​ mice​​​​​ shown ,​​​​​​ that​​​ Inulin​​​​​ to​ one​​​​ RESTORE​​​​​​​​​​​​​​​​ the​​ a n t i m i c r o b i e l l e n P o r t i o n​​​​​​​ in the Colon​​​ contributes​​​​​​​ and thus​​​​​​ could protect against possible obesity- related intestinal inflammation.  

    • Relief from depression – Since the gut microbiome is also strongly linked to the brain and has shown considerable influence on psychological illnesses , inulin could also have positive , supporting​​​​​​​​​​​​​ Effects​​​​​​​​ at​​ Diseases​​​​​​​​​​​ How​​ D e p r e s s i o n e s l i e f e r n . Studies have shown improved memory and antidepressant effects when taking inulin .  

     

    Foods containing inulin  

    Foods that are good sources of inulin are: artichoke, Garlic , leek, shallot, asparagus, yacon root , chicory root and onion .  

    Possible side effects 

    Fibers such as inulin have a beneficial effect on the intestines, but can cause bloating and diarrhea in some people, especially those who are not used to a high-fiber diet.  

    To support the effect of probiotics 

    A diet rich in fiber usually supports the effects of probiotics, as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured. 

    We at AgilNature have in our “ SynbioticAgil ” product that provides you with probiotics such as Bifidobacterium lactis and others , we also take care to include prebiotics for maximum effectiveness. Our product SynbioticAgil also contains the prebiotic inulin. 

    Which AgilNature ® products contain Inulin ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    3.02​ g per daily ration ( 6 capsule n )  

    **  

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. Dietary Fiber. DGE. https://www.dge.de/gesunde-ernaehrung/faq/ausgewaehlte-fragen-und-antworten-zu-ballaststoffen/ ( Accessed on May 19, 2024) 

    1. Rehberg, C. (2024, April 26). Inulin: Effects and Properties of the Prebiotic. Center for Health. https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/praebiotika-uebersicht/inulin (Accessed on May 19, 2024) 

    1. Qin YQ, Wang LY, Yang XY, Xu YJ, Fan G, Fan YG, Ren JN, An Q, Li X. Inulin: properties and health benefits. Food Function . 2023 Apr 3;14(7):2948-2968 . 

    1. Shoaib M, Shehzad A, Omar M, Rakha A, Raza H, Sharif HR, Shakeel A, Ansari A, Niazi S. Inulin: Properties, health benefits and food applications. Carbohydr Polym. 2016 Aug 20;147:444 -454 . 

    1. Ahmed W, Rashid S. Functional and therapeutic potential of inulin: A comprehensive review. Crit Rev Food Sci Nutr . 2019;59(1):1-13 . 

    1. Hughes RL, Alvarado DA, Swanson KS, Holscher HD. The Prebiotic Potential of Inulin-Type Fructans : A Systematic Review. Adv Nutr . 2022 Mar;13(2):492-529. 

    1. Tawfick MM, Xie H, Zhao C, Shao P, Farag MA. Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics. Int J Biol Macromol . 2022 May 31;208:948 -961. 

    1. Wan X, Guo H, Liang Y, Zhou C, Liu Z, Li K, Niu F, Zhai X, Wang L. The physiological functions and pharmaceutical applications of inulin: A review. Carbohydr Polym . 2020 Oct 15;246:116589 . 

    1. Akram W, Pandey V, Sharma R, Joshi R, Mishra N, Garud N, Haider T. Inulin: Unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics. Int J Biol Macromol . 2024 Feb;259(Pt 1):129131 

    1. Vandeputte D, Falony G, Vieira-Silva S, Wang J, Sailer M, Theis S, Verbeke K, Raes J. Prebiotic inulin-type fructans induce specific changes in the human gut microbiota. Good. 2017 Nov;66(11):1968-1974. 

    1. Birkeland E, Gharagozlian S, Birkeland KI, Valeur J, Måge I, Rud I, Aas AM. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomized controlled trial. Eur J Nutr . 2020 Oct;59(7):3325-3338. 

    1. Guimarães JB, Rodrigues VF, Pereira ÍS, Manso GMDC, Elias-Oliveira J, Leite JA, Waldetario MCGM, de Oliveira S, Gomes ABDSP, Faria AMC, Ramos SG, Bonato VLD, Silva JS, Vinolo MAR, Sampaio UM, Clerici MTPS, Carlos D. Inulin prebiotic ameliorates type 1 diabetes dictating regulatory T cell Homing via CCR4 to pancreatic islets and butyrogenic gut microbiota in murine model. J Leukoc Biol. 2024 Feb 23;115(3):483-496. 

    1. Beisner J, Filipe Rosa L, Kaden-Volynets V, Stolzer I, Günther C, Bischoff SC. Prebiotic Inulin and Sodium Butyrate Attenuate Obesity-Induced Intestinal Barrier Dysfunction by Induction of Antimicrobial Peptides. Front Immunol. 2021 Jun 11;12:678360 . 

    1. Visuthranukul C, Chamni S, Kwanbunbumpen T, Saengpanit P, Chongpison Y, Tepaamorndech S, Panichsillaphakit E, Uaariyapanichkul J, Nonpat N, Chomtho S. Effects of inulin supplementation on body composition and metabolic outcomes in children with obesity. Sci Rep. 2022 Jul 29;12(1):13014 . 

    1. Bakirhan H, Karabudak E. Effects of inulin on calcium metabolism and bone health. Int J Vitam Nutr Res. 2023 Feb;93(1):85-96 . 

  • Sonnenblumenöl
    Agil Nature

    Sunflower oil

    Origin and history :  

    Whether as a radiant, symbolic flower or as oil in the kitchen, the sunflower ( Helianthus annuus ) is an indispensable part of everyday life. The one- to two-meter-long plant blooms from late June/July to September. Sunflowers are considered highly photosynthetic and therefore bind a lot of carbon dioxide. This makes the yellow flowers very light-dependent. The size and orientation of the plant depend on from the sun. First cultivated by Native Americans, the sunflower spread to Europe in the 16th century . One specially bred variety of sunflowers today is the high- oleic sunflower, or HO sunflower for short. HO sunflowers are defined as sunflowers with a minimum oleic acid content of 80% , which is the most common simply unsaturated fatty acid that we humans consume in our diet .  

    Characteristics :  

    The amount of oleic acid in the flowers is of interest to many oil producers, as the oil is considered to be very heat and oxidation stable , making it ideal for frying and deep-frying. However, from a health perspective , it is also important to to consider this monounsaturated fatty acid , which is part of animal and vegetable oils. Studies suggest that a diet rich in oleic acid is beneficial for weight regulation and could lead to weight loss, particularly in cases of obesity and abdominal fat deposits. Studies also attribute the blood pressure-lowering effect of olive oil to its oleic acid content. Monounsaturated fatty acids such as oleic acid also reduce “bad” LDL cholesterol while increasing “good” HDL cholesterol, which is associated with a lower risk of cardiovascular disease . In one study, a higher level of oleic acid in Blood plasma with a 73% lower risk of strokes .  

     

    Which AgilNature ® products contain High oleic sunflower oil ? 

    product 

    Crowd 

    NRV * 

    Omega3Agil  

    31.9 mg per daily ration ( 3 capsules each )  

    **  

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. High oleic sunflower Oil . https://www.sunflowernsa.com/oil/High-Oleic-Sunflower-Oil/ (accessed on February 19, 2024) 

    1. Salas JJ, Martínez-Force E, Harwood JL, Venegas- Calerón M, Aznar-Moreno JA, Moreno-Pérez AJ, Ruíz-López N, Serrano-Vega MJ, Graham IA, Mullen RT, Garcés R. Biochemistry of high stearic sunflower , a new source of saturated fats . Prog Lipid Res. 2014 Jul;55:30 -42. 

    1. Tutunchi , Helda ; East Adrahimi , Alireza; Saghafi-Asl , Maryam (2020). "The Effects of Diets Enriched in Monounsaturated Oleic Acid on the Management and Prevention of Obesity : a Systematic Review of Human Intervention Studies". Advances in Nutrition. 11 (4): 864–877. 

    1. Samieri C, Féart C, Proust-Lima C, Peuchant E, Tzourio C, Stapf C, Berr C, Barberger- Gateau P. Olive oil consumption , plasma oleic acid , and stroke incidence : the Three -City Study. Neurology . 2011 Aug 2;77(5):418-25. 

    1. Terés , S., Barceló- Coblijn , G., Benet, M., Alvarez, R., Bressani , R., Halver, JE, & Escribá , PV (2008). Oleic acid content is responsible for the reduction in blood pressure induced by olive oil . Proceedings of the National Academy of Sciences of the United States of America , 105(37), 13811–13816. 

  • DHA & EPA Algenöl
    Agil Nature

    DHA & EPA algae oil

    Origin and history :  

    Docosahexaenoic acid (DHA ) and eicosapentaenoic acid (EPA) are among the polyunsaturated omega-3 fatty acids that are directly available to the body. Omega-3 fatty acids must be obtained from food because our body cannot produce them itself , but they are urgently needed for metabolism and cell development . EPA is for our body a precursor to DHA. Contrary to the original formulation, EPA is not only a direct precursor to DHA; rather, both fatty acids perform independent functions in the body. These fatty acids are normally found in larger quantities in fatty fish products such as salmon. One vegan alternative we use is the extraction of fatty acids from algae.  

    Characteristics :  

    These vital building blocks for our body are necessary for a healthy metabolism and brain development . They are specifically required for a number of different functions, such as the regulation of blood lipid levels and inflammatory reactions , hormone production, and the formation of cell membranes. DHA is the most abundant omega-3 fatty acid in the central nervous system due to its essential functions in this area. It is required not only for vision, but also for signal transmission within the nervous system . Since it is particularly important for brain development, pregnant women are advised to ensure adequate DHA intake.  

    The European Food Safety Authority (EFSA) has evaluated and approved the following DHA/EPA -related health claims based on scientific studies for a daily intake of 250 mg DHA /EPA :   

    • DHA contributes to the maintenance of normal brain function  

    • DHA contributes to the maintenance of normal vision  

    • EPA and DHA contribute to normal heart function  

    The combination of DHA/EPA has been discussed for some time as a potential way to reduce the risk of cardiovascular disease . Studies have associated higher intake of these fatty acids with lower mortality from cardiovascular disease , and they are thought to play a role in prevention . DHA/EPA properties include a beneficial effect on lipid metabolism, blood pressure regulation, cardiac function, and inflammatory responses. These combined effects may potentially reduce the risk of cardiovascular disease .  

    A positive relationship to psychological disorders such as depression and neurodegenerative diseases like Alzheimer's In one study, DHA+ EPA supplementation , as well as EPA alone , led to a reduction in depressive symptoms in affected subjects . Therefore, omega-3 supplementation is also recommended by international health authorities for at-risk groups such as sick children, pregnant women, and the elderly.  

     

    Recommended intake  

    According to the German Nutrition Society (DGE), pregnant and breastfeeding women need a daily intake of 200 milligrams of DHA for the healthy development of their children. There is no general intake recommendation, except for pregnant or breastfeeding women.  

    Possible side effects  

    Taking DHA/EPA can cause side effects in diabetics, as it impairs blood sugar control and adversely affects the immune system. LDL cholesterol levels are also affected and may increase. It is advisable to consult a doctor before taking Consult a doctor. The immune system may be impaired in older people.  

    Possible interactions​  

    Interactions with anticoagulant medications such as aspirin may occur, as higher DHA/EPA doses may alter the flow properties of the blood and thus increase the risk of bleeding.  

    Bioavailability of algal oil  

    The bioavailability of algal oil is in no way inferior to that of fish oil. In comparative studies, fatty acid absorption of algal and fish oil was equally good and within a similar range. Some studies even suggest a potentially superior efficacy of algal oil compared to tuna oil , as algal oil demonstrated a more sustained, longer-term release and greater intestinal digestibility.  

    Algae cultivation  

    Algae can be cultivated in three different ways. There are open tanks in which the algae can be cultivated, and closed bioreactors. There are two different types of bioreactors: photobioreactors , which use constant light as energy for cultivation and thus consume electricity for lighting, and heterotrophic bioreactors, which use carbon sources as energy and thus consume energy for constant gas exchange, but allow for higher biomass.  

    Algal oil and the environment  

    The constant demand for fish for their unique nutritional value, such as omega-3 fatty acids, causes fish stocks to increase to a maximum each year to supply fish for human consumption, which significantly impacts fish populations and leads to the possibility of extinction. Supplying the required aquaculture is accompanied by marine pollution from chemicals, antibiotics, and broken net cages. While algal oil consumes energy such as electricity to grow the algae in bioreactors , it is generally a more environmentally friendly alternative to most fish sources. The algae's ability to sequester CO2 contributes to its sustainability by helping to reduce the carbon footprint of its production. Furthermore, algae can be produced on non-arable land using non-potable water (including brackish or seawater). Because algae can grow densely, one study has shown that algae can produce 167 times more useful biomass annually than corn when using the same area.  

     

    Which AgilNature ® products contain DHA and EPA algae oil ? 

    product 

    Crowd 

    NRV * 

    Omega3Agil  

    962.7 mg per daily ration ( 3 capsules each )  

    **  

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. Is algal oil a plant-based alternative for omega-3 fatty acids? | Verbraucherzentrale.de. Verbraucherzentrale.de. https://www.verbraucherzentrale.de/wissen/lebensmittel/gesund-ernaehren/ist-algenoel-eine-pflanzliche-alternative-fuer-omega3fettsaeuren-51990 (a bg called on February 12, 2024) 

    1. Fat, essential fatty acids. DGE. https://www.dge.de/wissenschaft/referenzwerte/fett-essenzielle-fettsaeuren/ (accessed on February 12, 2024) 

    1. BfR: For the fortification of foods with omega-3 fatty acids, the BfR recommends setting maximum levels. BfR Opinion No. 030/2009 of May 26, 2009. (accessed on February 15, 2024) 

    1. Rehberg, C. (2023, August 4). Omega 3 - The Effects of Fatty Acids. Center for Health. https://www.zentrum-der-gesundheit.de/ernaehrung/nahrungsergaenzung/omega-3-uebersicht/omega-3 (accessed on February 15, 2024) 

    1. Djuricic I, Calder PC. Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients . 2021 Jul 15;13(7):2421. 

    1. Kelsey MD, Pagidipati NJ. Should We "RESPECT EPA" More Now ? EPA and DHA for Cardiovascular Risk Reduction . Curr Cardiol Rep. 2023 Nov;25(11):1601-1609. 

    1. Elagizi A, Lavie CJ, O'Keefe E, Marshall K, O'Keefe JH, Milani RV. An Update on Omega-3 Polyunsaturated Fatty Acids and Cardiovascular Health. Nutrients . 2021 Jan 12;13(1):204. 

    1. Wang X, Xiao A, Yang Y, Zhao Y, Wang CC, Wang Y, Han J, Wang Z, Wen M. DHA and EPA Prevent Seizure and Depression-Like Behavior by Inhibiting Ferroptosis and Neuroinflammation via Different Mode- of -Actions in a Pentylenetetrazole-Induced Kindling Model in Mice . Mol Nutr Food Res. 2022 Nov;66(22 ):e 2200275. 

    1. Peng Z, Zhang C, Yan L, Zhang Y, Yang Z, Wang J, Song C. EPA is More Effective than DHA to Improve Depression-Like Behavior , Glia Cell Dysfunction and Hipcampal Apoptosis Signaling in a Chronic Stress -Induced Rat Model of Depression. Int J Mol Sci . 2020 Mar 5;21(5):1769. 

    1. Kousparou C, Fyrilla M, Stephanou A, Patrikios I. DHA/EPA (Omega-3) and LA/GLA (Omega-6) as Bioactive Molecules in Neurodegenerative Diseases . Int J Mol Sci . 2023 Jun 27;24(13):10717. 

    1. Stiefvatter , L., Lehnert, K., Frick, K., Montoya-Arroyo, A., Frank, J., Vetter, W., Schmid-Staiger, U., & Bischoff, S.C. (2021). Oral Bioavailability of Omega-3 Fatty Acids and Carotenoids from the Microalgae Phaeodactylum tricornutum in Healthy Young Adults . Marine drugs , 19(12), 700. 

    1. Hu Z, Wu P, Wang L, Wu Z, Chen XD. Exploring in vitro release and digestion of commercial DHA microcapsules from algae oil and tuna oil with whey protein and casein as wall materials . Food Function . 2022 Jan 24;13(2):978-989. 

    1. Lenihan-Geels G, Bishop KS, Ferguson LR. Alternative Sources of Omega-3 Fats : Can We Find a Sustainable Substitute for Fish? Nutrients . 2013; 5(4):1301-1315. 

    1. Diaz, CJ, Douglas, KJ, Kang, K., Kolarik, AL, Malinovski , R., Torres- Tiji , Y., Molino, JV, Badary , A. & Mayfield, S.P. (2023). Developing algae as a sustainable food source. Frontiers in Nutrition, 9, 1029841. 

  • Bifidobacterium lactis
    Agil Nature

    Bifidobacterium lactis

    Bifidobacterium lactis , also Bifidobacterium animalis ssp . lactis , is a gram-positive lactic acid bacterium of the family Bifidobacteriaceae . As a lactic acid bacterium, it ferments glucose, the simple sugar, into lactic acid , which is also used as the food additive E 270. Since milk is only in the name and has nothing to do with lactose, lactose-intolerant people have nothing to fear. Lactic acid bacteria are among the “good”, health-promoting bacteria that we naturally have in our gut.  

    Bifidobacterium animalis ssp . lactis finds its use as a probiotic . Probiotics are living microorganisms that, in certain quantities, offer health benefits for example by influencing the intestinal microbiome . B. lactis is in abundant products used, mainly in dairy products . For example , it is also used in some yogurts in Lidl , listed as " Bifidobacterium BB-12" or in the prominent probiotic Activia yogurts. It is believed that B. lactis the gastrointestinal passage survived well and also has the potential to colonize the intestinal flora over a longer period of time . When taken with inulin, a concomitant dietary fiber, B. lactis was found in stool samples even two weeks after ingestion, indicating successful , long-term colonization in the intestine .  

    Numerous beneficial effects of the bacterium that have been discovered so far and are interesting as a probiotic:  

    • Provides digestive support: B. lactis Helps digest fiber and plant substances . Since they are not among the bacteria that produce gas during digestion, they can divert fermentation in the large intestine to a non-gaseous end product and thus reduce potential flatulence. In a study on elderly people who consumed 1 x 10 9 CFU/day of B. lactis ( our SynbioticAgil contains 6 times that amount!) , more regular bowel movements were found on 26.9% of days . The number of test subjects who had normal bowel movements on more than 30% of days increased by 114% .  

    • Help with diarrhea: In addition to helping with constipation, A prominent feature of B. lactis is its ability to help with diarrhea. Especially in the elderly , but also in young children and those with antibiotic-associated problems, B. lactis helped to normalize bowel movements. In patients who underwent a 14-day antibiotic therapy and B. lactis income, the strength and risk possible diarrhea symptoms . The risk decreased to 10.8%, compared to the control group, which had a 15.56% risk. The duration also decreased to approximately 2 days instead of 4.  

    • Promotes intestinal health: An imbalance between a healthy gut and the intestinal flora leads to various inflammatory processes in the body. This imbalance is believed to be related to obesity and weight regulation. B. lactis promotes a healthy balance in the gut and supports its protective function. This keeps bacteria in the gut and reduces the risk of inflammation. According to a study, B. lactis as a probiotic, the intestinal flora of overweight subjects is adapted to the intestinal flora composition that is usually associated with a slimmer phenotype .  

    • Weight control: Through its positive influence on intestinal health , B. lactis also positively influences weight. Supplementation with B. lactis According to studies, it leads to a significant reduction in total body fat mass , food intake , and waist circumference. Fat deposits are particularly reduced in the abdominal area. This is also reflected in the BMI, which was reduced with long-term consumption of B. lactis . Studies assume that fat deposits are reduced due to the positive influence of B. lactis on fatty acid metabolism.  

    • Immune system regulation: It is suspected that B. lactis can help regulate the immune response against pathogens. Laboratory experiments have shown an improvement in the immune response against pathogens such as S. typhimurium , which is often involved in food poisoning due to poor food hygiene. B. lactis has also been shown to be effective against oxidative stress . helpful in rats .  

    • Respiratory symptoms of colds : Studies on toddlers and schoolchildren suggest that B. lactis could help increase the organism's resistance to common infections by strengthening the immune system . According to the studies , B. lactis also reduce the frequency and duration of respiratory infections.  

    • Lowering blood pressure: In combination with Lactobacillus rhamnosus In one study, taking probiotics after 16 weeks reduced blood pressure by changing the composition of the intestinal flora. In combination with the right probiotics , B. lactis may therefore have a positive effect on blood pressure when taken over a longer period of time.  

    • Baby colic: Known as baby colic , or three-month colic , is a period in which babies cry excessively, thought to be caused by abdominal pain , which may be related to the microbiome in the gut. Giving babies B. lactis halved the risk of colic in 80 percent of cases. the length of crying phases. The babies' stools also improved. ( Even though B. lactis is considered beneficial for children and babies, you should consult a doctor before taking it .)  

     

    Further studies  

    Other health benefits found and suspected in studies include :  

    • Type 1 diabetes : According to one study, a six-month supplementation of a mixture of different probiotics, including B. lactis , with concomitant insulin therapy helped improve insulin therapy. Conventional insulin therapy plus probiotics reduced diabetes symptoms by better stabilizing blood sugar levels and lowering HbA1c levels . It's important to note that probiotics are by no means a substitute for insulin therapy, but the right probiotics can potentially enhance it!  

    • Women's health : Together with other probiotics in the mix, B. lactis A positive effect on vascular function and arterial stiffness in overweight postmenopausal women was also shown . In addition, an improvement in bone metabolism was observed in postmenopausal osteoporosis with reduced inflammation.  

    • Coronary heart disease: The simultaneous Taking B.lactis with a conventional therapy regimen ( with atorvastatin and Metoprolol ) is thought to offer additional benefits compared to conventional treatment alone, for example by increasing anti-inflammatory microbial species in the gut , modulating the concentration of certain biological metabolites and more.  

    • Supports fat metabolism and sports performance : An 8-week course of B. lactis supplementation combined with exercise training showed positive changes in fatty acid metabolism in ski athletes . Concentrations of triglycerides, LDL-C, and bile acids were reduced, accompanied by a significant increase in short-chain fatty acids, which are considered healthy for the body. This was also accompanied by improved muscle strength and oxygen uptake during endurance exercise.  

    • Irritable bowel syndrome: Together with Lactobacillus acidophilus , B. lactis subjects to relieve the symptoms of chronic irritable bowel syndrome and improve the quality of life, especially through shorter and milder pain symptoms.  

    • Alzheimer's: One of the main triggers for Alzheimer's is beta-amyloid plaques in the brain. In a 6-week study on mice, it was found that taking B. lactis reduced beta-amyloid plaque burden throughout the brain . Additionally, a preventive effect on improving working memory was observed.  

    Recommended dosages and instructions for use  

    The optimal dosage of Bifidobac terium lactis may vary depending on individual health status and desired effect. Generally, dosages in dietary supplements range between 1 and 2 billion colony-forming units (CFU) per day.  

    Nutritional recommendations to support the effect  

    A diet rich in fiber usually supports the effectiveness of probiotics , as prebiotics such as fiber promote the growth and activity of probiotic bacteria in the gut. Foods such as whole grain products, vegetables, and fruit are recommended. Adequate fluid intake should also be ensured.  

    We at AgilNatur e have in our “ SynbioticAgil ” product that provides you with probiotics such as Bifidobacterium lactis , we also take care of prebiotics to achieve the best effect. Our product SynbioticAgil contains additionally the prebiotic inulin.  

    Dangers of taking  

    The intake of Bifidobacterium Lactis is considered safe for health , even in the elderly and children . However, some probiotics can rarely cause sepsis in certain at-risk groups. People with weak immune systems and babies are considered at-risk and should therefore avoid taking it without consulting a doctor.  

     

    Which AgilNature ® products contain Bifidobacterium lactis ? 

    product 

    Crowd 

    NRV * 

    SynbioticAgil  

    5.9 x 10 9 CFU per daily ration (6 capsules)  

    ** 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No. 1169/2011.  

    ** No recommendation available.  

    *** CFU = Colony Forming Units  

     

    Literature :  

    1. Zhang Y, Zheng T, Ma D, Shi P, Zhang H, Li J, Sun Z.2023 .Probiotics Bifidobacterium lactis M8 and Lactobacillus rhamnosus M9 prevent high blood pressure via modulating the gut microbiota composition and host metabolic products. mSystems 8:e 00331-23 . 

    1. Uusitupa HM, Rasinkangas P, Lehtinen MJ, Mäkelä SM, Airaksinen K, Anglenius H, Ouwehand AC, Maukonen J. Bifidobacterium animalis subsp. lactis 420 for Metabolic Health: Review of the Research. Nutrients. 2020 Mar 25;12(4):892. 

    1. Stenman, LK, Lehtinen, MJ, Meland, N., Christensen, JE, Yeung, N., Saarinen, MT, Courtney, M., Burcelin , R., Lähdeaho , M.-L., Linros , J., Apter, D., Scheinin , M., Smerud, HK, Rissanen, A. & Lahtinen, S. (2016). Probiotic With or Without Fiber Controls Body Fat Mass, Associated With Serum Zonulin , in Overweight and Obese Adults—Randomized Controlled Trial. EBioMedicine , 13, 190–200. 

    1. Pedret A, Valls RM, Calderón-Pérez L, Llauradó E, Companys J, Pla -Pagà L, Moragas A, Martín-Luján F, Ortega Y, Giralt M, Caimari A, Chenoll E, Genovés S, Martorell P, Codoñer FM, Ramón D, Arola L, Solà R. Effects of daily consumption of the probiotic Bifidobacterium animalis subsp. lactis CECT 8145 on anthropometric adiposity biomarkers in abdominally obese subjects: a randomized controlled trial. Int J Obes (Lond). 2019 Sep;43(9):1863-1868. 

    1. Balaguer F, Enrique M, Llopis S, Barrena M, Navarro V, Álvarez B, Chenoll E, Ramón D, Tortajada M, Martorell P. Lipoteichoic acid from Bifidobacterium animalis subsp. lactis BPL1: a novel postbiotic that reduces fat deposition via IGF-1 pathway. Microb Biotechnol . 2022 Mar;15(3):805-816 . 

    1. Ban OH, Lee M, Bang WY, Nam EH, Jeon HJ, Shin M, Yang J, Jung YH. Bifidobacterium lactis IDCC 4301 Exerts Anti-Obesity Effects in High-Fat Diet-Fed Mice Model by Regulating Lipid Metabolism. Mol Nutr Food Res. 2023 Feb;67(3 ):e 2200385. 

    1. Cheng J, Laitila A, Ouwehand AC. Bifidobacterium animalis subsp. lactis HN019 Effects on Gut Health: A Review. Front Nutr . 2021 Dec 14;8:790561 . 

    1. Jungersen M, Wind A, Johansen E, Christensen JE, Stuer-Lauridsen B, Eskesen D. The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12(®). Microorganisms. 2014 Mar 28;2(2):92-110. 

    1. Michels M, Córneo E, Cucker L, Simon CS, de Jesus GFA, Michels C, Madeira K, Voytena AP, Rossetto M, Ramlov F, de Castro Damásio D, Dal-Pizzol F. Bifidobacterium lactis CCT 7858 Improves Gastrointestinal Symptoms by Antibiotics Treatment: a Double-Blind, Randomized, Placebo-Controlled Trial. Probiotics Antimicrob Proteins. 2023 Jun;15(3):738-748. 

    1. Xu B, Liang S, Zhao J, Li X, Guo J, Xin B, Li B, Huo G, Ma W. Bifidobacterium animalis subsp. lactis XLTG11 improves antibiotic-related diarrhea by alleviating inflammation, enhancing intestinal barrier function and regulating intestinal flora. Food Function . 2022 Jun 6;13(11):6404-6418 . 

    1. Vitheejongjaroen P, Kasorn A, Puttarat N, Loison F, Taweechotipatr M. Bifidobacterium animalis MSMC83 Improves Oxidative Stress and Gut Microbiota in D-Galactose-Induced Rats. Antioxidants (Basel). 2022 Oct 29;11(11):2146. 

    1. Nocerino R, De Filippis F, Cecere G, Marino A, Micillo M, Di Scala C, de Caro C, Calignano A, Bruno C, Paparo L, Iannicelli AM, Cosenza L, Maddalena Y, Della Gatta G, Coppola S, Carucci L, Ercolini D, Berni Canani R. The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12® in infant colic: A randomized , double blind, placebo-controlled trial. Aliment Pharmacol Ther. 2020 Jan;51(1):110-120. 

    1. Wang, CH, Yen, HR, Lu, WL, Ho, HH, Lin, WY, Kuo, YW, Huang, YY, Tsai, SY, & Lin, HC (2022). Adjuvant Probiotics of Lactobacillus salivarius subsp. salicinius AP-32, L. johnsonii MH-68, and Bifidobacterium animalis subsp. lactis CP-9 Attenuate Glycemic Levels and Inflammatory Cytokines in Patients With Type 1 Diabetes Mellitus. Frontiers in endocrinology, 13, 754401. 

    1. Siddiqui R, Makhlouf Z, Alharbi AM, Alfahemi H, Khan NA. The Gut Microbiome and Female Health. Biology (Basel). 2022 Nov 21;11(11):1683 . 

    1. Sun B, Ma T, Li Y, Yang N, Li B, Zhou mSystems . 2022 Apr 26;7(2 ):e 0010022. 

    1. Li T, Rui Z, Mao L, Chang Y, Shao J, Chen Y, Han Q, Sui Nutrients. 2023 Oct 27;15(21):4554 . 

    1. Martoni CJ, Srivastava S, Leyer GJ. Lactobacillus acidophilus DDS-1 and Bifidobacterium lactis UABla-12 Improve Abdominal Pain Severity and Symptomology in Irritable Bowel Syndrome: Randomized Controlled Trial. Nutrients. 2020 Jan 30;12(2):363. 

    1. Zhao F, Guo Z, Kwok LY, Zhao Z, Wang K, Li Y, Sun Z, Zhao J, Zhang H. Bifidobacterium lactis Probio-M8 improves bone metabolism in patients with postmenopausal osteoporosis, possibly by modulating the gut microbiota. Eur J Nutr . 2023 Mar;62(2):965-976. 

    1. Cao J, Amakye WK, Qi C, Liu X, Ma J, Ren J. Bifidobacterium Lactis Probio-M8 regulates gut microbiota to alleviate Alzheimer's disease in the APP/PS1 mouse model. Eur J Nutr . 2021 Oct;60(7):3757-3769. 

    1. Tsai HY, Wang YC, Liao CA, Su CY, Huang CH, Chiu MH, Yeh YT. Safety and the probiotic potential of Bifidobacterium animalis CP-9. J Food Sci. 2022 May;87(5):2211-2228 . 

  • Rosmarin
    Agil Nature

    Rosemary

    Origin and history :  

    Rosemary ( Salvia rosmarinus , Rosemary (formerly known as Rosmarinus officinalis ) is widely known for its widespread use in cooking, but also as a frequently used fragrance in aroma and care products. The plant originally comes from the western and central Mediterranean. Today, rosemary is cultivated worldwide as a spice. The evergreen, bushy rosemary shrub grows between 20 cm and 2 m tall and bears light blue, pink, or white flowers.  

    Rosemary has a rich history and symbolism. Its use dates back to ancient Egypt. Among the Romans and Greeks, it was a symbol of love in many myths and customs. In Germany, too, it was long customary for brides to wear rosemary wreaths. It also served as a memorial to the dead. But not only as a symbol, it also had great and diverse significance as a medicinal plant.  

    Characteristics :  

    Rosemary was highly valued in ancient medicine as a medicinal plant that purified the air, promoted circulation, and invigorated the body. Even today, rosemary is used to strengthen the body during times of stress and illness. The oil is particularly popular in aromatherapy for its invigorating and energizing effects, helping to relieve mental and physical exhaustion and improving concentration and memory. Recent studies have confirmed rosemary's positive effects on cognitive function and memory, with the essential oil and its main components, such as 1,8-cineole, being particularly effective. Research also suggests that rosemary may be potentially beneficial in the treatment of neurodegenerative diseases.  

    The strengthening effect stems from rosemary's ability to promote circulation and blood flow. Today, rosemary is used to treat gastrointestinal complaints and to relieve pain from tension, headaches, sore throats, asthma, and stomach aches.  

    In addition to its aromatherapy benefits for well-being, rosemary is also attributed many other medicinal uses. Rosemary's main property is its powerful anti-inflammatory effect, which therapists often use to treat rheumatic conditions such as arthritis . Rosemary also contains vitamins such as vitamin C, vitamin B6, thiamin (vitamin B1), and minerals such as iron, calcium, and magnesium. Rosemary also contains antioxidants such as rosmarinic acid, which have anti-inflammatory properties and may contribute to protection against oxidative stress.  

    In addition, rosemary extract has been found to have a liver-protective effect due to its antioxidant properties and the activation of protective mechanisms.  

    Possible side effects  

    While rosemary is generally considered safe in culinary amounts, therapeutic doses should be taken with caution. High doses can cause gastrointestinal upset, and pregnant women should consult a physician before using rosemary as a supplement. People with high blood pressure or epilepsy should also exercise caution.  

     

      

     

    Literature :  

    1. de Oliveira JR, Camargo SEA, de Oliveira LD. Rosmarinus officinalis L. ( rosemary ) as therapeutic and prophylactic agent . J Biomed Sci . 2019 Jan 9;26(1):5. 

    1. Luo, C., Zou, L., Sun, H., Peng, J., Gao, C., Bao, L., Ji, R., Jin, Y., & Sun, S. (2020). A review of the Anti -Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases . Frontiers in pharmacology , 11, 153. 

    1. Sayorwan W, Ruangrungsi N, Piriyapunyporn T, Hongratanaworakit T, Kotchabhakdi N, Siripornpanich V. Effects of inhaled rosemary oil on subjective feelings and activities of the nervous system . Sci Pharm. 2013 Apr-Jun;81(2):531-42. 

    1. Moss M, Cook J, Wesnes K, Duckett P. Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults . Int J Neurosci . 2003 Jan;113(1):15-38. 

    1. Borges RS, Ortiz BLS, Pereira ACM, Keita H, Carvalho JCT. Rosmarinus officinalis essential oil : A review of its phytochemistry , anti- inflammatory activity , and mechanisms of action involved . J Ethnopharmacol . 2019 Jan 30;229:29 -45. 

    1. Rašković , A., Milanović, I., Pavlović , N., Ćebović , T., Vukmirović , S., & Mikov , M. (2014). Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC complementary and alternative medicine , 14, 225. 

    1. Barao Paixão VL, Freire de Carvalho J. Essential oil therapy in rheumatic diseases : A systematic review. Complement Ther Clin Pract . 2021 May;43:101391 . 

    1. Momeni Safarabadi A, Gholami M, Kordestani-Moghadam P, Ghaderi R, Birjandi M. The effect of rosemary hydroalcoholic extract on cognitive function and activities of daily life living of patients with chronic obstructive pulmonary disease (COPD): A clinical trial. Explore (NY). 2023 Sep 21:S 1550-8307(23)00228-8. 

  • Kakao
    Agil Nature

    Cocoa

    Origin and history  

     
    Cacao (Theobroma cacao ) is native to the tropical regions of Central and South America and was cultivated over 3,000 years ago by the Olmecs , Maya, and Aztecs. The Aztecs not only used cacao beans as currency but also prepared a ritual drink called " Xocoatl ," which was considered invigorating. Cacao was brought to Europe by the Spanish conquerors in the 16th century, where it quickly gained popularity. In the centuries that followed, numerous processing methods were developed, and cacao became a valued luxury item in many cultures. 

    Today, cocoa is mainly grown in West Africa, South America, and Southeast Asia. The largest producers are Côte d'Ivoire, Ghana, Ecuador, and Brazil. In addition to its role in the food industry, cocoa is increasingly used in cosmetics and pharmaceuticals. Cocoa butter is particularly valued in natural cosmetics for its moisturizing and nourishing properties. Cocoa is also becoming increasingly relevant in functional nutrition, especially in the form of raw cocoa, which is considered a superfood. 

    Use of cocoa for flavor  

    Cocoa is popular not only for its health benefits, but also for its unique flavor profile. Its aroma, with bitter, earthy, and slightly sweet notes, makes it a versatile food. In the food industry, cocoa is often used to make chocolate, desserts, baked goods, and beverages. Due to its natural bitter taste, cocoa is ideal for masking unwanted flavors in functional foods and dietary supplements. That's why we have included it in ProteinAgil. Defatted cocoa powder is used to mask the typical pea flavor while still benefiting from the health benefits of cocoa. By using high-quality cocoa powder in our formulation, we combine nutritional benefits with a pleasant taste experience without resorting to artificial flavors. Cocoa not only improves the product's acceptability but also contributes to its functionality. 

    Ingredients  

    The health benefits of cocoa are manifold:  

    Flavonoids (especially epicatechin , catechin , and procyanidins ) – These secondary plant substances are among the most effective antioxidants. They can neutralize free radicals and thus prevent cell damage. Flavonoids are also known for their vascular-protective properties, as they improve blood vessel elasticity and promote blood flow. They also have anti-inflammatory effects and can reduce the risk of cardiovascular disease.  

    Theobromine and Caffeine ( methylxanthines with stimulant properties) – Theobromine is the dominant alkaloid in cocoa and has a mild stimulant effect, more gentle than that of caffeine. It stimulates the central nervous system, dilates blood vessels, and can improve mood. Caffeine, also present in smaller amounts, can increase alertness and concentration by influencing the release of neurotransmitters such as dopamine.  

    Polyphenols – These bioactive substances have powerful antioxidant properties and are known to inhibit inflammation. They play an important role in protecting the skin by slowing down skin aging and protecting against UV-induced stress. They also support the immune system and contribute to the regulation of blood sugar levels.  

    Fiber – Cocoa contains soluble and insoluble fiber, which aids digestion. It contributes to the regulation of intestinal flora by supporting the growth of healthy gut bacteria. Fiber is also important for maintaining stable blood sugar levels and promotes satiety, which can have a positive effect on body weight.  

    Minerals such as iron, magnesium, potassium, phosphorus, and zinc – These essential micronutrients are vital for numerous metabolic processes in the body. Iron is crucial for oxygen transport in the blood, magnesium supports muscle function and the nervous system, potassium is important for fluid balance, phosphorus plays a central role in energy metabolism, and zinc contributes to strengthening the immune system.  

    Various vitamins (especially B vitamins and vitamin E) – B vitamins are essential for energy metabolism and nervous system function. Vitamin E is a powerful antioxidant that protects cells from oxidative stress and supports healthy skin.  

    Tryptophan – This amino acid is a precursor to serotonin, the so-called "happy hormone." Serotonin influences mood, sleep patterns, and general well-being. Adequate tryptophan consumption can help alleviate depressive moods and improve sleep quality.  

    Anandamide – A bioactive compound that binds to the body's endocannabinoid system and can enhance feelings of well-being. Anandamide is often referred to as the "happy molecule" because it has similar effects to the body's own endocannabinoids and can therefore contribute to the regulation of emotions and stress.  

    Phenylethylamine (PEA) – Another neuroactive compound associated with the release of dopamine. It can induce feelings of euphoria and is often referred to as the "love chemical" because it can have similar effects to natural infatuation.  

    This combination of bioactive compounds makes cocoa an exceptional food with comprehensive health benefits.  

     

    Health benefits and current studies  

    The health benefits of cocoa are manifold:  

    • Cardiovascular health: The flavonoids found in cocoa can lower blood pressure, improve endothelial function, and reduce the risk of cardiovascular disease. They contribute to blood vessel elasticity and can help improve blood circulation.  

    • Neuroprotective effects: Flavonoids in cocoa can improve cognitive performance and reduce the risk of neurodegenerative diseases. Studies indicate that regular cocoa consumption supports memory and learning ability.  

    • Antioxidant effect: Cocoa has a high antioxidant capacity that can reduce oxidative cell damage and inhibit inflammatory processes. The polyphenols it contains also have a protective effect on DNA.  

    • Mood-enhancing properties: Theobromine and tryptophan can stimulate serotonin production and contribute to mood improvement. This can have a positive effect on stress management and overall well-being.  

    • Gut health: Certain polyphenols in cocoa promote the growth of beneficial bacteria such as bifidobacteria and lactobacilli , thus supporting a healthy gut flora. A healthy gut microbiome is closely linked to a strong immune system and good nutrient absorption.  

    • Blood sugar regulation: Cocoa can improve insulin sensitivity and help reduce blood sugar fluctuations, which is particularly important for people at increased risk of diabetes.  

     

    Recommended daily dose  

    There is no official recommended daily intake for cocoa. Studies suggest that 10–30 g of dark chocolate with a high cocoa content (at least 70%) daily may provide health benefits, particularly for the cardiovascular system. Raw cocoa in powder or nib form is often recommended as a functional food at 5–10 g per day. However, excessive intake can lead to side effects due to the theobromine and caffeine content.  

     

    What is unique about cocoa ?  

    Cocoa is one of the richest natural sources of flavonoids and theobromine. The combination of these bioactive substances gives cocoa antioxidant, anti-inflammatory, and stimulating properties. Unlike coffee, cocoa contains less caffeine but a high amount of theobromine, which has a more gentle stimulating effect. Cocoa is also characterized by its versatile uses—both as a food and in skincare, where it possesses moisturizing and protective properties. Due to its positive effects on well-being and cognitive performance, cocoa is increasingly considered a natural mood enhancer .  

     

    Which foods contain cocoa ?  

    • Dark chocolate (at least 70% cocoa content)  

    • Cocoa powder (unsweetened)  

    • cocoa nibs  

    • Cocoa butter (but does not contain flavonoids)  

    • Drinking chocolate  

    • Cocoa beans (raw, often consumed as a superfood)  

    • Raw cocoa products such as smoothies, energy balls or cocoa snacks  

     

    Possible side effects  

    • Caffeine and theobromine effects : High consumption can cause restlessness, sleep disturbances or palpitations.  

    • Gastrointestinal problems: Some people are sensitive to the tannins contained in cocoa, which can lead to digestive problems.  

    • Histamine release: Cocoa can trigger headaches or allergy-like reactions in sensitive individuals.  

    • Weight gain: Highly processed cocoa products often contain sugar and fat, which can lead to increased calorie consumption.  

    • Acidity: Cocoa can cause heartburn or hyperacidity in sensitive individuals.  

     

    Possible interactions with other substances  

    Blood pressure medications: Flavonoids can enhance blood pressure lowering effects.  

    Antidepressants (MAOIs): Theobromine may affect the effect of MAOIs.  

    Blood thinners: The antioxidant compounds in cocoa can increase the effects of blood thinning medications.  

    Iron absorption: The polyphenols contained in cocoa can inhibit iron absorption, especially in people with iron deficiency.  

    Medications for blood sugar regulation: Due to the potential blood sugar-lowering effect of cocoa, interactions may occur when combined with diabetes medications.  

     

    Sources  

    1. Tan TYC, Lim XY, Yeo JHH, Lee SWH, Lai NM. The Health Effects of Chocolate and Cocoa: A Systematic Review. Nutrients. 2021 Aug 24;13(9):2909. doi : 10.3390/nu13092909. PMID: 34578786; PMCID: PMC8470865.
    2. Katz DL, Doughty K, Ali A. Cocoa and chocolate in human health and disease. Antioxidant redox signal. 2011 Nov 15;15(10):2779-811. doi : 10.1089/ars.2010.3697. Epub 2011 Jun 13. PMID: 21470061; PMCID: PMC4696435.
    3. María Ángeles Martin, Sonia Ramos, Impact of cocoa flavanols on human health, Food and Chemical Toxicology, Volume 151, 2021, 112121, ISSN 0278-6915, https://doi.org/10.1016/j.fct.2021.112121 .
    4. Shin, Ji-Hee et al. “Consumption of 85% cocoa dark chocolate improves mood in association with gut microbial changes in healthy adults: a randomized controlled trial.” The Journal of nutritional biochemistry vol. 99 (2022): 108854. doi:10.1016/j.jnutbio .2021.108854
    5. Higginbotham, Erin, and Pam R Taub. “Cardiovascular Benefits of Dark Chocolate?. ” Current treatment options in cardiovascular medicine vol. 17.12 (2015): 54. doi:10.1007/s11936-015-0419-5
    6. Sorrenti V, Ali S, Mancin L, Davinelli S, Paoli A, Scapagnini G. Cocoa Polyphenols and Gut Microbiota Interplay: Bioavailability, Prebiotic Effect, and Impact on Human Health. Nutrients. 2020 Jun 27;12(7):1908. doi : 10.3390/nu12071908. PMID: 32605083; PMCID: PMC7400387.
    7. Edo GI, Samuel PO, Oloni GO, et al. Review on the Biological and Bioactive components of Cocoa (Theobroma Cacao). Insight on Food, Health and Nutrition. Natural Resources for Human Health. 2023;3(4):426-448. doi:10.53365/ nrfhh /174302.  
  • Melisse
    Agil Nature

    Lemon balm

    Origin and history :  

    The best known and most used balm is lemon balm ( Melissa officinalis ) . Lemon balm originates from the eastern Mediterranean and western Asia. It is now also cultivated in central, western and eastern Europe. Lemon balm is a perennial herbaceous plant that can grow up to 90 cm tall . Its leaves are oval, serrated and have a soft, felty texture. In summer, small, white or pale yellow flowers appear that are attractive to bees and other pollinators. Lemon balm prefers sunny to partially shaded locations and well-drained soil. The Greeks and Romans already considered lemon balm a medicinal plant. In the Middle Ages it was brought to Germany and initially grown in monastery gardens and later in farm gardens . As the name suggests, lemon balm leaves have a lemon-like smell. This makes the plant ideal not only for use in food supplements but also as a component in tea, where it is said to have a calming digestive effect. Thanks to its aroma, lemon balm is also often used in the kitchen to flavor desserts and drinks. The aroma is also used in perfumery.  

    General text:  

    Traditionally, lemon balm is used for gastrointestinal complaints and problems falling asleep, as the contained essential oil which is said to have calming and anxiolytic properties in herbal medicine.  Lemon balm contains various active ingredients such as rosmarinic acid, terpenes and flavonoids. Rosmarinic acid has anti-inflammatory and antioxidant properties, while terpenes contribute to the plant's calming effect. Folk medicine also uses lemon balm for colds and poor circulation. However, the best known and most common use of lemon balm is against insomnia and sleeplessness. 

    The current research basis also confirms the likely anti-anxiety, stress-relieving and antidepressant effects of the plant. A neuroprotective effect of the plant is also suspected , as it is an antioxidant and could therefore protect against oxidative damage that leads to neurological disorders such as Alzheimer's . For example, a recent study found less cognitive decline in older people compared to a control group that did not receive lemon balm extract for years. 

    Other biological properties attributed to lemon balm are that it is antiviral ( against herpes , HIV, SARS-CoV-2 and influenza , for example ) , is antibacterial, anti-inflammatory and therefore pain-relieving. The antioxidant effect could also have benefits for irritated skin when applied externally. Studies have found that lemon balm extract caused fewer small capillaries to form, the skin remained more hydrated due to less water loss and inflammatory redness was reduced. 

     

    Further texts :​  

     

    Benefits for the Bees 

    In ancient times it was already noticed that the scent of the nectar-rich plant attracts bees. The term lemon balm is derived from the Greek word for honey bee. Since it seems to attract bees, the nectar-rich plant was also used in bee houses in the past and is ideal as a bee pasture. It is also cultivated as such and thus helps the bees to survive. 

    Which AgilNature ® products contain lemon balm ?  

    product 

    Crowd 

    NRV * 

    RelaxAgil night 

    80 mg per 1 capsule (daily ration ) 

    ** 

    FemAgil 

    40 mg per 2 capsules (daily ration ) 

     

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1st Babar Ali, Naser Ali Al- Wabel , Saiba Shams, Aftab Ahamad , Shah Alam Khan, Firoz Anwar , Essential oils used in aromatherapy : A systemic review, Asian Pacific Journal of Tropical Biomedicine , Volume 5, Issue 8, 2015, Pages 601-611, ISSN 2221-1691.  

    2. Max Wichtl (ed.): Tea herbs and phytopharmaceuticals. 4th edition. Wissenschaftliche Verlagsgesellschaft, Stuttgart, 2002, ISBN 3-8047-1854-X, pp. 382–386.  

    4. Ghazizadeh J, Sadigh-Eteghad S, Marx W, Fakhari A, Hamedeyazdan S, Torbati M, Taheri -Tarighi S, Araj-Khodaei M, Mirghafourvand M. The effects of lemon balm (Melissa officinalis L.) on depression and anxiety in clinical trials : A systematic review and meta-analysis. Phytother Res. 2021 Dec;35(12):6690-6705.  

    4 . Petrisor G, Motelica L, Craciun LN, Oprea OC, Ficai D, Ficai A. Melissa officinalis: Composition , Pharmacological Effects and Derived Release Systems-A Review. Int J Mol Sci . 2022 Mar 25;23(7):3591.  

    5 . Noguchi- Shinohara M, Hamaguchi T, Sakai K, Komatsu J, Iwasa K, Horimoto M, Nakamura H, Yamada M, Ono K. Effects of Melissa officinalis Extract Containing Rosmarinic Acid on Cognition in Older Adults Without Dementia: A Randomized Controlled trial. J Alzheimer's Dis. 2023;91(2):805-814.  

    6 . Zam W, Quispe C, Sharifi-Rad J, López MD, Schoebitz M, Martorell M, Sharopov F, Fokou PVT, Mishra AP, Chandran D, Kumar M, Chen JT, Pezzani R. An Updated Review on The Properties of Melissa officinalis L.: Not Exclusively Anti- anxiety . Front Biosci ( Schol Ed). 2022 Jun 7;14(2):16.  

    7. Behzadi A, Imani S, Deravi N, Mohammad Taheri Z, Mohammadian F, Moraveji Z, Shavysi S, Mostafaloo M, Soleimani Hadidi F, Nanbakhsh S, Olangian -Tehrani S, Marabi MH, Behshood P, Poudineh M, Kheirandish A, Keylani K, Behfarnia P. Antiviral Potential of Melissa officinalis L.: A Literature Review. Nutr Metab Insights . 2023 Jan 12;16:11786388221146683 .  

    8. Sipos S, Moacă EA, Pavel IZ, Avram Ş, Crețu OM, Coricovac D, Racoviceanu RM, Ghiulai R, Pană RD, Şoica CM, Borcan F, Dehelean CA, Crăiniceanu Z. Melissa officinalis L. Aqueous Extract Exerts Antioxidant and Antiangiogenic Effects and Improves Physiological Skin Parameters. Molecules . 2021 Apr 19;26(8):2369.  

  • Meerrettich
    Agil Nature

    Horseradish

    Origin and history :  

    Horseradish ( Armoracia rusticana ) is known for the use of its root in kitchens as a vegetable and spice. Originally from the Ukraine and the European part of Russia , it spread worldwide very early on. In some empires in ancient times, it was not cultivated in Germany until the Middle Ages. But it was not only used in the kitchen, because even then the medicinal significance of horseradish was clear. This even gave rise to the superstition of the time that a necklace made of horseradish had healing powers. At that time it was used against scurvy, poisoning, fever and digestive problems. In Asian medicine it was also valued for its pain-relieving and anti-inflammatory properties. Horseradish also plays a role in Jewish tradition, particularly during Passover as a symbol of the bitterness of slavery in Egypt. In countries outside Japan horseradish is also often used as a substitute for real wasabi.  

     

    General text:  

    Traditionally, horseradish is used against bacterial infections of the respiratory tract and urinary tract infections. The reason for this is the isothiocyanates contained in the plant , also known as mustard oils. They are responsible for the characteristic smell and taste of vegetables such as kohlrabi, radishes and horseradish. These isothiocyanates give horseradish antibacterial properties, even against known pathogens such as E. coli , salmonella and staphylococci. The isothiocyanates in horseradish, such as benzyl isothiocyanate (BITC), have antiviral and antifungal effects in addition to their antibacterial properties.  

    Horseradish also has an anti-inflammatory effect on bacterial infections, which provides additional relief from infections. In one study, horseradish extract showed an improvement in bronchitis symptoms in test subjects. The anti-inflammatory effect also extends to the neurons in the brain. Some of the active ingredients contained in horseradish also have neuroprotective properties, which could make the vegetable a potential preventative agent against neurodegenerative diseases such as Alzheimer's, dementia and Parkinson's.  

    In addition, horseradish has antioxidant properties, which experiments have shown the ability to protect cells from oxidative stress.  

      

      

    Horseradish has a high content of vitamin C, which acts as an antioxidant in our body and thus supports the immune system. Other nutrients such as sodium, potassium and calcium are also contained in large quantities. It also contains B vitamins, which are important for nerve function and energy metabolism. It also provides fiber, which supports good digestion.  

     

    Further texts :​  

    Be careful when taking  

    People with gastrointestinal diseases or hyperthyroidism should consult their doctor before consumption  

     

    Which AgilNature ® products contain horseradish extract ?  

    product 

    Crowd​ 

    NRV * 

    Detox Agil  

    1 0 0 mg per 6 capsules (daily ration ) 

    * * 

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. " Nutrient content of prepared horseradish per 100 g". FoodData Central, US Department of Agriculture . 1 April 2018. https://fdc.nal.usda.gov/fdc-app.html#/food-details/173472/nutrients (accessed on 17.01.2024)  

    1. Antibiotic therapy with medicinal plants. In: Planta Med , 3, 1955, pp. 1–16.  

    1. Manuguerra S, Caccamo L, Mancuso M, Arena R, Rappazzo AC, Genovese L, Santulli A, Messina CM, Maricchiolo G. The antioxidant power of horseradish , Armoracia rusticana, underlies antimicrobial and antiradical effects exerted in vitro . Nat Prod Res. 2020 Jun;34(11):1567-1570.  

    1. Herz C, Tran HT, Márton MR, Maul R, Baldermann S, Schreiner M, Lamy E. Evaluation of an Aqueous Extract from Horseradish Root ( Armoracia rusticana Radix) against Lipopolysaccharide- Induced Cellular Inflammation Reaction . Evid Based Complement Alternat Med. 2017;2017:1950692 .  

    1. Marzocco S, Calabrone L, Adesso S, Larocca M, Franceschelli S, Autore G, Martelli G, Rossano R. Anti- inflammatory activity of horseradish ( Armoracia rusticana) root extracts in LPS- stimulated macrophages . Food Function . 2015 Dec;6(12):3778-88.  

    1. Negro EJ, Sendker J, Stark T, Lipowicz B, Hensel A. Phytochemical and functional analysis of horseradish ( Armoracia rusticana) fermented and non- fermented root extracts . Physiotherapy . 2022 Oct;162:105282 .  

    1. Albrecht U, Stefenelli U, Stange R. A combination of Tropaeolum majus herb and Armoracia rusticana root for the treatment of acute bronchitis . Phytomedicine . 2023 Jul 25;116:154838 .  

    1. Lee TH, Yoon DH, Park KJ, Hong SM, Kim M, Kim SY, Kim CS, Lee KR. Neurotrophic phenolic glycosides from the roots of Armoracia rusticana. Phytochemistry . 2023 Dec;216:113886 .  

    1. Lee TH, Khan Z, Kim SY, Lee KR. Thiohydantoin and Hydantoin Derivatives from the Roots of Armoracia rusticana and Their Neurotrophic and Anti- neuroinflammatory Activities . J Nat Prod . 2019 Nov 22;82(11):3020-3024.  

    1. Henklewska , M., Pawlak, A., Li, RF, Yi, J., Zbyryt , I., & Obmińska-Mrukowicz , B. (2021). Benzyl Isothiocyanate , a Vegetable-Derived Compound, Induces Apoptosis via ROS Accumulation and DNA Damage in Canine Lymphoma and Leukemia Cells. International journal of molecular sciences , 22(21), 11772.  

  • Guarbohnen
    Agil Nature

    Guar beans

    Origin and history :  

    Guar beans ( Cyamopsis tetragonoloba ) , also known as guar , belongs to the legume family and is thought to have originated in Central Africa or India. It is now mainly cultivated in India. Guar beans can be eaten as a vegetable, but are also used as animal feed or for regenerating soil after harvest. The plant grows up to 2 meters tall and produces approximately 10 cm long, multi- seeded legumes that are used to produce guar gum.  

    Characteristics :  

    Guar gum is made from the seeds of the guar bean and is used as a natural thickener in cosmetics , food and medicinal products that is biodegradable . As an additive, it is also known under the number E 412. The protein-rich germs used consist largely of galactomannan , a polysaccharide made up of a chain of mannose with galactose molecules attached to the sides . Galaktomann​ has a high hydrogen binding capacity, which leads to thickening through water binding. Therefore, guar gum is also used in industry as a thickener or stabilizer.  

    Other applications  

    Guar is of particular interest to the pharmaceutical industry, where the plant is being studied in the context of targeted drug delivery in the body. It is hoped that guar will improve the efficiency and localization of some drugs by improving the bioavailability of the active ingredients . This also includes its ability to stabilize blood sugar levels and promote digestive health through its high fiber content. The role of guar gum in weight regulation through the feeling of satiety is also worth mentioning .  

    Possible applications for the environment  

    Guar can also be of interest to the environment . Water pollution such as paint residues and heavy metals are common and pose a danger to humans and the environment. Therefore, methods for water purification are urgently needed. One of the possible substances being investigated for water purification is guar , as bind these heavy metal ions and other contaminants can , as well as have an antibacterial effect and could also eliminate dangerous microorganisms in the water.  

    Possible side effects  

    Guar gum is suspected of promoting the development of allergies and of triggering allergic reactions itself. Cross-allergies can occur in people who are allergic to soy.  

    Since we cannot fully digest and absorb guar gum ourselves, but our intestinal bacteria break it down, gas is formed. Consuming large amounts can therefore lead to flatulence and abdominal cramps.  

    Because of its high swelling capacity and the resulting increased risk of damage to the stomach and intestines, as well as the esophagus, guar gum should always be consumed with sufficient liquid.  

     

     Which AgilNature ® products contain Guar gum ?  

    product 

    ProteinAgil  

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. Mudgil , D.; Barak, S.; Khatkar , B.S. (2011). " Guar gum : Processing, properties and food applications —A Review". Journal of Food Science and Technology. 51 (3): 409–18. 

    1. 412 Guar gum – Additives Online. https://www.zusatzstoffe-online.de/zusatzstoffe/412-guarkernmehl/ (accessed on February 15, 2024) 

    1. Amjed N, Zeshan M, Farooq A, Naz S. Applications of guar gum polysaccharides for pharmaceutical drug delivery : A review. Int J Biol Macromol . 2024 Feb;257(Pt 1):128390. 

    1. Garg SS, Gupta J. Guar gum-based nanoformulations : Implications for improving drug delivery . Int J Biol Macromol . 2023 Feb 28;229:476 -485. 

    1. Mandal S, Hwang S, Shi SQ. Guar gum , a low-cost sustainable biopolymer, for wastewater treatment : A review. Int J Biol Macromol . 2023 Jan 31;226:368 -382. 

    1. Saya L, Malik V, Singh A, Singh S, Gambhir G, Singh WR, Chandra R, Hooda S. Guar gum based nanocomposites : Role in water purification through efficient removal of dyes and metal ions . Carbohydr Polym . 2021 Jun 1;261:117851 . 

    1. Mohammad Javad Alaeian , Sanaz Pourreza , Mohsen Yousefi , Elnaz Golalipour , Leila Setayesh , Mohammad Zeinali Khosroshahi , Reza Bagheri, Damoon Ashtary-Larky , Alexei Wong, Mohammad Zamani, Omid Asbaghi , The effects of guar gum supplementation on glycemic control , body mass and blood pressure in adults : A GRADE- assessed systematic review and meta-analysis of randomized clinical trials , Diabetes Research and Clinical Practice, Volume 199, 2023, 110604, ISSN 0168-8227. 

  • Erbse
    Agil Nature

    Pea

    Origin and history :  

    The pea ( Pisum sativum ) has been an important crop and part of the human diet for thousands of years . Each pod contains several seeds, which can have green or yellow peas when ripe. It has been cultivated since 8,000 BC , making it one of the oldest cultivated plants. Originally it grows wild in Asia Minor, but has spread worldwide and was at times considered a delicacy in cultures such as medieval Europe. The plant is rich in nutrients and has become increasingly popular in recent years as a vegan alternative to protein powders due to its numerous health and sustainability benefits.  

    Characteristics :  

    A protein source that is quite unexpected for many people is peas. The average protein content of peas is around 22%. Rich in protein, minerals and vitamins such as Rich in vitamin B , as well as being high in fiber and low in fat , pea protein is a good protein alternative for anyone who wants to avoid animal products. In addition, plant-based protein sources are associated with a lower risk of various metabolic diseases such as diabetes, cancer and heart disease than animal-based sources. Pea protein is generally hypoallergenic and has numerous health benefits, such as antioxidant, blood pressure lowering, cholesterol lowering and anti-inflammatory properties. Blood sugar also rises less after meals when pea protein is consumed. The high fiber content also benefits the intestines and has an activating effect on them . In addition, flatulence occurs less frequently. due to the high digestibility of the product.  

    What makes peas such an excellent source of protein is not only the protein content, but also the fact that they contain all 9 essential amino acids. While the sulfur-containing amino acids are contained in smaller quantities, the lysine content is very high. All amino acids that our body cannot produce itself and that must be taken in through food are considered essential. This is usually not the case with plant-based protein sources , but peas and some other plants such as soybeans are an exception.  

    Pea protein is a preferred choice for many people due to its hypoallergenicity and the fact that it is GMO-free. Unlike rice or hemp protein, which can be lower in certain essential amino acids  

    environmental friendliness  

    Compared to other protein-rich foods and other protein products such as whey and soy protein powders , the production of pea protein powder is much better for the environment. The reason for this is the lower amount of water and fertilizers needed. For example, 1 g of protein from beef requires 6 times more water than 1 g of protein from peas.  

    Peas are known for their ability to fix nitrogen from the air, which reduces the need for artificial fertilizers and contributes to soil health. These sustainable farming practices make pea protein not only a healthy choice, but also an environmentally friendly one.  

    target group  

    For athletes, pea protein offers an effective way to support muscle building and recovery, while for vegans and vegetarians it plays an essential role in ensuring adequate protein intake. People with gluten intolerance or lactose intolerance can also benefit from pea protein as it is a safe and tolerable source of protein.  

    Quality  

    When purchasing pea protein products, it is important to pay attention to the quality and origin. Products made from non-GMO peas without the addition of artificial colors or flavors offer the purest form of the protein. Third-party certifications can further confirm the quality and sustainability of the product.  

     Which AgilNature ® products contain pea protein ?  

    product 

    Crowd 

    ProteinAgil  

    81%  

     

    * Nutrient Reference Value = percentage of the reference value according to Annex XIII of the Food Information Regulation (EC) No 1169/2011.  

    ** No recommendation available.  

     

    Literature :  

    1. Shanthakumar P, Klepacka J, Bains A, Chawla P, Dhull SB, Najda A. The Current Situation of Pea Protein and Its Application in the Food Industry. Molecules . 2022; 27(16):5354. 

    1. Dahl WJ, Foster LM, Tyler RT. Review of the health benefits of peas ( Pisum sativum L.). British Journal of Nutrition. 2012;108(S1 ):S 3-S10. 

    1. ACY Lam, A Can Karaca, RT Tyler & MT Nickerson (2018) Pea protein isolates : Structure , extraction , and functionality , Food Reviews International, 34:2, 126-147. 

    1. Krefting , Jessica (September 2017). "The Appeal of Pea Protein". Journal of Renal Nutrition. 27 (5): e31–e33 

    1. Nadathur SR; Wanasundara JPD; Scanlin L, eds . (November 2016). Sustainable Protein Sources. Elsevier. ISBN 978-0-12-802778-3. 

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